ID   RL12_HALSA              Reviewed;         114 AA.
AC   P05768; Q9HQL5;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   25-MAY-2022, entry version 121.
DE   RecName: Full=50S ribosomal protein L12 {ECO:0000255|HAMAP-Rule:MF_01478};
DE   AltName: Full=HL20;
DE   AltName: Full=Ribosomal protein 'A';
GN   Name=rpl12 {ECO:0000255|HAMAP-Rule:MF_01478}; OrderedLocusNames=VNG_1103G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A9;
RA   Itoh T., Kumazaki T., Sugiyama M., Otaka E.;
RT   "Molecular cloning and sequence analysis of the ribosomal 'A' protein gene
RT   from the archaebacterium, Halobacterium halobium.";
RL   Biochim. Biophys. Acta 949:110-118(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=R1 / S9;
RX   PubMed=2458258; DOI=10.1111/j.1432-1033.1988.tb14281.x;
RA   Itoh T.;
RT   "Complete nucleotide sequence of the ribosomal 'A' protein operon from the
RT   archaebacterium, Halobacterium halobium.";
RL   Eur. J. Biochem. 176:297-303(1988).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 33170 / DSM 669 / NCCB 81095 / NRC 34001;
RX   PubMed=2743981; DOI=10.1002/j.1460-2075.1989.tb03496.x;
RA   Shimmin L.C., Dennis P.P.;
RT   "Characterization of the L11, L1, L10 and L12 equivalent ribosomal protein
RT   gene cluster of the halophilic archaebacterium Halobacterium cutirubrum.";
RL   EMBO J. 8:1225-1235(1989).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
RN   [5]
RP   PROTEIN SEQUENCE OF 1-76.
RA   Yaguchi M., Matheson A.T., Visentin L.P., Zuker M.;
RL   (In) Osawa S., Ozeki H., Uchida H., Yura T. (eds.);
RL   Genetics and evolution of RNA polymerase, tRNA and ribosomes, pp.585-599,
RL   University of Tokyo Press, Tokyo (1980).
CC   -!- FUNCTION: Forms part of the ribosomal stalk, playing a central role in
CC       the interaction of the ribosome with GTP-bound translation factors.
CC       {ECO:0000255|HAMAP-Rule:MF_01478}.
CC   -!- SUBUNIT: Part of the 50S ribosomal subunit. Homodimer, it forms part of
CC       the ribosomal stalk which helps the ribosome interact with GTP-bound
CC       translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex,
CC       where L10 forms an elongated spine to which the L12 dimers bind in a
CC       sequential fashion. {ECO:0000255|HAMAP-Rule:MF_01478}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein P1/P2 family.
CC       {ECO:0000255|HAMAP-Rule:MF_01478}.
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DR   EMBL; X06736; CAA29915.1; -; Genomic_DNA.
DR   EMBL; X13008; CAA31432.1; -; Genomic_DNA.
DR   EMBL; X15078; CAA33181.1; -; Genomic_DNA.
DR   EMBL; AE004437; AAG19498.1; -; Genomic_DNA.
DR   PIR; F84266; F84266.
DR   PIR; S01745; R5HS2H.
DR   RefSeq; WP_010902793.1; NC_002607.1.
DR   AlphaFoldDB; P05768; -.
DR   SMR; P05768; -.
DR   STRING; 64091.VNG_1103G; -.
DR   PaxDb; P05768; -.
DR   EnsemblBacteria; AAG19498; AAG19498; VNG_1103G.
DR   GeneID; 5952834; -.
DR   GeneID; 62886620; -.
DR   KEGG; hal:VNG_1103G; -.
DR   PATRIC; fig|64091.14.peg.844; -.
DR   HOGENOM; CLU_114656_2_0_2; -.
DR   InParanoid; P05768; -.
DR   OMA; EYIYAAM; -.
DR   OrthoDB; 128352at2157; -.
DR   Proteomes; UP000000554; Chromosome.
DR   GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0006414; P:translational elongation; IEA:InterPro.
DR   CDD; cd05832; Ribosomal_L12p; 1.
DR   Gene3D; 1.10.10.1410; -; 1.
DR   HAMAP; MF_01478; Ribosomal_L12_arch; 1.
DR   InterPro; IPR038716; P1/P2_N_sf.
DR   InterPro; IPR027534; Ribosomal_L12/P1/P2.
DR   InterPro; IPR022295; Ribosomal_L12_arc.
DR   TIGRFAMs; TIGR03685; ribo_P1_arch; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Reference proteome; Ribonucleoprotein;
KW   Ribosomal protein.
FT   CHAIN           1..114
FT                   /note="50S ribosomal protein L12"
FT                   /id="PRO_0000157628"
FT   REGION          55..114
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..107
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   114 AA;  11562 MW;  CBEB2E38BD4A644C CRC64;
     MEYVYAALIL NEADEELTED NITGVLEAAG VDVEESRAKA LVAALEDVDI EEAVEEAAAA
     PAAAPAASGS DDEAAADDGD DDEEADADEA AEAEDAGDDD DEEPSGEGLG DLFG