ID   RL12_RAT                Reviewed;         165 AA.
AC   P23358;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   03-AUG-2022, entry version 160.
DE   RecName: Full=60S ribosomal protein L12;
GN   Name=Rpl12;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Liver;
RX   PubMed=1977388; DOI=10.1016/s0006-291x(05)80169-x;
RA   Suzuki K., Olvera J., Wool I.G.;
RT   "The primary structure of rat ribosomal protein L12.";
RL   Biochem. Biophys. Res. Commun. 172:35-41(1990).
CC   -!- FUNCTION: Binds directly to 26S ribosomal RNA.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL11 family.
CC       {ECO:0000305}.
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DR   EMBL; X53504; CAA37581.1; -; mRNA.
DR   PIR; A36667; R7RT12.
DR   RefSeq; NP_001102668.1; NM_001109198.1.
DR   RefSeq; XP_006227318.1; XM_006227256.3.
DR   RefSeq; XP_006256697.1; XM_006256635.3.
DR   AlphaFoldDB; P23358; -.
DR   SMR; P23358; -.
DR   BioGRID; 271090; 4.
DR   BioGRID; 3430786; 1.
DR   IntAct; P23358; 5.
DR   MINT; P23358; -.
DR   STRING; 10116.ENSRNOP00000041462; -.
DR   CarbonylDB; P23358; -.
DR   iPTMnet; P23358; -.
DR   PhosphoSitePlus; P23358; -.
DR   jPOST; P23358; -.
DR   PaxDb; P23358; -.
DR   PRIDE; P23358; -.
DR   Ensembl; ENSRNOT00000042736; ENSRNOP00000041462; ENSRNOG00000028993.
DR   GeneID; 102555453; -.
DR   GeneID; 499782; -.
DR   KEGG; rno:102555453; -.
DR   KEGG; rno:499782; -.
DR   UCSC; RGD:1565106; rat.
DR   CTD; 6136; -.
DR   RGD; 1565106; Rpl12.
DR   eggNOG; KOG0886; Eukaryota.
DR   GeneTree; ENSGT00390000006922; -.
DR   HOGENOM; CLU_074237_5_0_1; -.
DR   InParanoid; P23358; -.
DR   OMA; QPPHDVI; -.
DR   OrthoDB; 1279477at2759; -.
DR   PhylomeDB; P23358; -.
DR   TreeFam; TF300123; -.
DR   Reactome; R-RNO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-RNO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   Reactome; R-RNO-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-RNO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   Reactome; R-RNO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-RNO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   PRO; PR:P23358; -.
DR   Proteomes; UP000002494; Chromosome X.
DR   Bgee; ENSRNOG00000028993; Expressed in ovary and 19 other tissues.
DR   ExpressionAtlas; P23358; baseline.
DR   Genevisible; P23358; RN.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IDA:RGD.
DR   GO; GO:0022626; C:cytosolic ribosome; ISO:RGD.
DR   GO; GO:0015934; C:large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; ISO:RGD.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0014069; C:postsynaptic density; ISO:RGD.
DR   GO; GO:0070180; F:large ribosomal subunit rRNA binding; IDA:RGD.
DR   GO; GO:0003735; F:structural constituent of ribosome; ISO:RGD.
DR   GO; GO:0045901; P:positive regulation of translational elongation; IDA:RGD.
DR   GO; GO:0006412; P:translation; IBA:GO_Central.
DR   CDD; cd00349; Ribosomal_L11; 1.
DR   Gene3D; 1.10.10.250; -; 1.
DR   Gene3D; 3.30.1550.10; -; 1.
DR   HAMAP; MF_00736; Ribosomal_L11; 1.
DR   InterPro; IPR000911; Ribosomal_L11/L12.
DR   InterPro; IPR036796; Ribosomal_L11/L12_N_sf.
DR   InterPro; IPR020783; Ribosomal_L11_C.
DR   InterPro; IPR036769; Ribosomal_L11_C_sf.
DR   InterPro; IPR020785; Ribosomal_L11_CS.
DR   InterPro; IPR020784; Ribosomal_L11_N.
DR   PANTHER; PTHR11661; PTHR11661; 1.
DR   Pfam; PF00298; Ribosomal_L11; 1.
DR   Pfam; PF03946; Ribosomal_L11_N; 1.
DR   SMART; SM00649; RL11; 1.
DR   SUPFAM; SSF46906; SSF46906; 1.
DR   SUPFAM; SSF54747; SSF54747; 1.
DR   PROSITE; PS00359; RIBOSOMAL_L11; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Isopeptide bond; Phosphoprotein; Reference proteome;
KW   Ribonucleoprotein; Ribosomal protein; RNA-binding; Ubl conjugation.
FT   CHAIN           1..165
FT                   /note="60S ribosomal protein L12"
FT                   /id="PRO_0000104458"
FT   MOD_RES         38
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P30050"
FT   MOD_RES         54
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P30050"
FT   MOD_RES         165
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P30050"
FT   CROSSLNK        40
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:P30050"
SQ   SEQUENCE   165 AA;  17846 MW;  6F1C882B6F2350F9 CRC64;
     MPPKFDPNEI KVVYLRCTGG EVGATSALAP KIGPLGLSPK KVGDDIAKAT GDWKGLRITV
     KLTIQNRQAQ IEVVPSASAL IIKALKEPPR DRKKQKNIKH NGNITFDEIV NIARQMRHRS
     LARELSGTIK EILGTAQSVG CNVDGRHPHD IIDDINSGAV ECPAS