RL12_SULAC
ID RL12_SULAC Reviewed; 105 AA.
AC P08055; P35022; Q4J8V4;
DT 01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-1998, sequence version 2.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=50S ribosomal protein L12 {ECO:0000255|HAMAP-Rule:MF_01478};
DE AltName: Full=Ribosomal protein 'A';
GN Name=rpl12 {ECO:0000255|HAMAP-Rule:MF_01478}; OrderedLocusNames=Saci_1456;
OS Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC
OS 15157 / NCIMB 11770).
OC Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Sulfolobus.
OX NCBI_TaxID=330779;
RN [1]
RP PROTEIN SEQUENCE.
RC STRAIN=ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770;
RA Matheson A.T., Louie K.A., Boeck A.;
RT "The complete amino acid sequence of the ribosomal A protein (L12) from the
RT archaebacterium Sulfolobus acidocaldarius.";
RL FEBS Lett. 231:331-335(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7966335; DOI=10.1006/jmbi.1994.1723;
RA Ramirez C., Shimmin L.C., Leggatt P., Matheson A.T.;
RT "Structure and transcription of the L11-L1-L10-L12 ribosomal protein gene
RT operon from the extreme thermophilic archaeon Sulfolobus acidocaldarius.";
RL J. Mol. Biol. 244:242-249(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2497941; DOI=10.1139/m89-036;
RA Ramirez C., Shimmin L.C., Newton C.H., Matheson A.T., Dennis P.P.;
RT "Structure and evolution of the L11, L1, L10, and L12 equivalent ribosomal
RT proteins in eubacteria, archaebacteria, and eucaryotes.";
RL Can. J. Microbiol. 35:234-244(1989).
RN [4]
RP ERRATUM OF PUBMED:2497941.
RA Ramirez C., Shimmin L.C., Newton C.H., Matheson A.T., Dennis P.P.;
RL Can. J. Microbiol. 35:975-975(1989).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770;
RX PubMed=15995215; DOI=10.1128/jb.187.14.4992-4999.2005;
RA Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E.,
RA Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.;
RT "The genome of Sulfolobus acidocaldarius, a model organism of the
RT Crenarchaeota.";
RL J. Bacteriol. 187:4992-4999(2005).
CC -!- FUNCTION: Forms part of the ribosomal stalk, playing a central role in
CC the interaction of the ribosome with GTP-bound translation factors.
CC {ECO:0000255|HAMAP-Rule:MF_01478}.
CC -!- SUBUNIT: Part of the 50S ribosomal subunit. Homodimer, it forms part of
CC the ribosomal stalk which helps the ribosome interact with GTP-bound
CC translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex,
CC where L10 forms an elongated spine to which the L12 dimers bind in a
CC sequential fashion. {ECO:0000255|HAMAP-Rule:MF_01478}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein P1/P2 family.
CC {ECO:0000255|HAMAP-Rule:MF_01478}.
CC -!- CAUTION: Was originally thought to originate from S.solfataricus strain
CC P1, but the culture was contaminated with S.acidocaldarius.
CC {ECO:0000305|PubMed:2497941}.
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DR EMBL; X59038; CAA41765.1; -; Genomic_DNA.
DR EMBL; CP000077; AAY80777.1; -; Genomic_DNA.
DR PIR; S53651; R5UC12.
DR RefSeq; WP_011278279.1; NC_007181.1.
DR AlphaFoldDB; P08055; -.
DR SMR; P08055; -.
DR STRING; 330779.Saci_1456; -.
DR EnsemblBacteria; AAY80777; AAY80777; Saci_1456.
DR GeneID; 3473495; -.
DR KEGG; sai:Saci_1456; -.
DR PATRIC; fig|330779.12.peg.1400; -.
DR eggNOG; arCOG04287; Archaea.
DR HOGENOM; CLU_114656_2_0_2; -.
DR OMA; EYIYAAM; -.
DR Proteomes; UP000001018; Chromosome.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0006414; P:translational elongation; IEA:InterPro.
DR CDD; cd05832; Ribosomal_L12p; 1.
DR Gene3D; 1.10.10.1410; -; 1.
DR HAMAP; MF_01478; Ribosomal_L12_arch; 1.
DR InterPro; IPR038716; P1/P2_N_sf.
DR InterPro; IPR027534; Ribosomal_L12/P1/P2.
DR InterPro; IPR022295; Ribosomal_L12_arc.
DR TIGRFAMs; TIGR03685; ribo_P1_arch; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein.
FT CHAIN 1..105
FT /note="50S ribosomal protein L12"
FT /id="PRO_0000157636"
FT REGION 65..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..94
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="Blocked amino end (Met)"
FT CONFLICT 46
FT /note="K -> E (in Ref. 1; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 105 AA; 11138 MW; 7B56E7CD5EA89C24 CRC64;
MEYIYASLLL HAAKKEISEE NIKNVLSAAG ITVDEVRLKA VAAALKEVNI DEILKTATAM
PVAAVAAPAG QQTQQAAEKK EEKKEEEKKG PSEEEIGGGL SSLFG
