ID   RL134_PLAVT             Reviewed;         506 AA.
AC   P0CV55;
DT   18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2019, sequence version 1.
DT   25-MAY-2022, entry version 7.
DE   RecName: Full=Secreted RxLR effector protein 134 {ECO:0000303|PubMed:29706971};
DE   Flags: Precursor;
GN   Name=RXLR134 {ECO:0000303|PubMed:29706971};
OS   Plasmopara viticola (Downy mildew of grapevine) (Botrytis viticola).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Plasmopara.
OX   NCBI_TaxID=143451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DOMAIN, FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=29706971; DOI=10.3389/fpls.2018.00286;
RA   Liu Y., Lan X., Song S., Yin L., Dry I.B., Qu J., Xiang J., Lu J.;
RT   "In planta functional analysis and subcellular localization of the oomycete
RT   pathogen Plasmopara viticola candidate RXLR effector repertoire.";
RL   Front. Plant Sci. 9:286-286(2018).
CC   -!- FUNCTION: Secreted effector that completely suppresses the host cell
CC       death induced by cell death-inducing proteins.
CC       {ECO:0000269|PubMed:29706971}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29706971}. Host
CC       nucleus {ECO:0000269|PubMed:29706971}. Note=Localizes to bulk/chunk-
CC       like structures within the nucleus. {ECO:0000269|PubMed:29706971}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:29706971}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   AlphaFoldDB; P0CV55; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Host nucleus; Secreted; Signal; Virulence.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..506
FT                   /note="Secreted RxLR effector protein 134"
FT                   /id="PRO_0000447965"
FT   MOTIF           50..71
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:29706971"
SQ   SEQUENCE   506 AA;  56090 MW;  44054A3AE834DB56 CRC64;
     MQGAYCVAVA LLIAASGQAA ANFGLEEPHQ APDSDFMASA DTIDEMLQSR VLQVSHYPKD
     DLMLLAGNEE RMLLARSNYL TKIPIPESIM TAANTMRMEG EASAIEAASK NVNQLRSNKR
     QPVASILNNV ARHMSTTPDS DKFLVAVEND RPLVLAKRQR SAAITENGAK FAKQDDYRPV
     LSGPFTTNDE ASNGRHNNQL FTLKALQLDK NENAGNVEDL WQEKKVSNRD LFHLLDEYEN
     SAYLTVVSRL EANAIEAISK NSIRLESNKG KPIAPTPNIK VDQELYAPPD TGKSPVLVST
     NIPYILAKRL KNEPPSAIIY NVAGFLAQHD YRPAPSGSSA ISADAPNGQL DNQLITQKAF
     WLDKNKHIDD VESLFKEDTV EHLSHLREGN GESAHFTAVD RQSEPIVWPK DSAVFPQPQK
     KVVLNEEVNK VHEAFLKAFN LPFHQYLRET VTMLGIARWK RNSSPNSRAA ISTLKIFAKN
     VDPKKLPKLL GTDFAKLQGD KKKHVA