ID   RL13A_PIG               Reviewed;         137 AA.
AC   Q95307; P79320;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=60S ribosomal protein L13a;
DE   Flags: Fragment;
GN   Name=RPL13A;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Small intestine;
RA   Winteroe A.K., Fredholm M.;
RT   "Evaluation and characterization of a porcine small intestine cDNA
RT   library.";
RL   Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Associated with ribosomes but is not required for canonical
CC       ribosome function and has extra-ribosomal functions. Component of the
CC       GAIT (gamma interferon-activated inhibitor of translation) complex
CC       which mediates interferon-gamma-induced transcript-selective
CC       translation inhibition in inflammation processes. Upon interferon-gamma
CC       activation and subsequent phosphorylation dissociates from the ribosome
CC       and assembles into the GAIT complex which binds to stem loop-containing
CC       GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as
CC       ceruplasmin) and suppresses their translation. In the GAIT complex
CC       interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and
CC       blocks the recruitment of the 43S ribosomal complex. Involved in
CC       methylation of rRNA. {ECO:0000250|UniProtKB:P40429}.
CC   -!- SUBUNIT: Component of the 60S ribosome. Component of the GAIT complex.
CC       Interacts with EIF4G1. {ECO:0000250|UniProtKB:P40429}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P40429}.
CC   -!- PTM: Phosphorylation at Ser-73 upon interferon-gamma treatment in
CC       macrophages involves a DAPK1-DAPK3 kinase cascade and is causing
CC       release from the ribosome, association with the GAIT complex and
CC       subsequent involvement in transcript-selective translation inhibition.
CC       {ECO:0000250|UniProtKB:P19253}.
CC   -!- PTM: Citrullinated by PADI4. {ECO:0000250|UniProtKB:P19253}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL13 family.
CC       {ECO:0000305}.
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DR   EMBL; Z81152; CAB03544.1; -; mRNA.
DR   EMBL; Z84103; CAB06326.1; -; mRNA.
DR   STRING; 9823.ENSSSCP00000003433; -.
DR   PaxDb; Q95307; -.
DR   PeptideAtlas; Q95307; -.
DR   PRIDE; Q95307; -.
DR   eggNOG; KOG3204; Eukaryota.
DR   InParanoid; Q95307; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0097452; C:GAIT complex; ISS:UniProtKB.
DR   GO; GO:0005840; C:ribosome; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:1901194; P:negative regulation of formation of translation preinitiation complex; ISS:UniProtKB.
DR   GO; GO:0017148; P:negative regulation of translation; ISS:UniProtKB.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   CDD; cd00392; Ribosomal_L13; 1.
DR   Gene3D; 3.90.1180.10; -; 1.
DR   HAMAP; MF_01366; Ribosomal_L13; 1.
DR   InterPro; IPR005822; Ribosomal_L13.
DR   InterPro; IPR023563; Ribosomal_L13_CS.
DR   InterPro; IPR005755; Ribosomal_L13_euk/arc.
DR   InterPro; IPR036899; Ribosomal_L13_sf.
DR   PANTHER; PTHR11545; PTHR11545; 1.
DR   Pfam; PF00572; Ribosomal_L13; 1.
DR   PIRSF; PIRSF002181; Ribosomal_L13; 1.
DR   SUPFAM; SSF52161; SSF52161; 1.
DR   TIGRFAMs; TIGR01077; L13_A_E; 1.
DR   PROSITE; PS00783; RIBOSOMAL_L13; 1.
PE   2: Evidence at transcript level;
KW   Citrullination; Cytoplasm; Phosphoprotein; Reference proteome;
KW   Ribonucleoprotein; Ribosomal protein; Translation regulation.
FT   CHAIN           <1..>137
FT                   /note="60S ribosomal protein L13a"
FT                   /id="PRO_0000133771"
FT   MOD_RES         55
FT                   /note="Citrulline"
FT                   /evidence="ECO:0000250|UniProtKB:P19253"
FT   MOD_RES         73
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P40429"
FT   MOD_RES         136
FT                   /note="Citrulline"
FT                   /evidence="ECO:0000250|UniProtKB:P19253"
FT   CONFLICT        16
FT                   /note="A -> V (in Ref. 1; CAB03544)"
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
FT   NON_TER         137
SQ   SEQUENCE   137 AA;  15674 MW;  C5245A7696CD0217 CRC64;
     QVLVLDGRGH LLGRLAAIVA KQVLLGRKVV VVRCEGINIS GNFYRNKLKY LAFLRKRMNT
     NPSRGPYHFR APSRIFWRTV RGMLPHKTKR GQAALDRLKV FDGIPPPYDK KKRMVVPAAL
     KVVRLKLTGK FXYLGRL