ID   RL13_CAEEL              Reviewed;         207 AA.
AC   P91128; Q86GU2;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=60S ribosomal protein L13;
GN   Name=rpl-13; ORFNames=C32E8.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Component of the ribosome, a large ribonucleoprotein complex
CC       responsible for the synthesis of proteins in the cell. The small
CC       ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the
CC       encoded message by selecting cognate aminoacyl-transfer RNA (tRNA)
CC       molecules. The large subunit (LSU) contains the ribosomal catalytic
CC       site termed the peptidyl transferase center (PTC), which catalyzes the
CC       formation of peptide bonds, thereby polymerizing the amino acids
CC       delivered by tRNAs into a polypeptide chain. The nascent polypeptides
CC       leave the ribosome through a tunnel in the LSU and interact with
CC       protein factors that function in enzymatic processing, targeting, and
CC       the membrane insertion of nascent chains at the exit of the ribosomal
CC       tunnel. As part of the LSU, it is probably required for its formation
CC       and the maturation of rRNAs. {ECO:0000250|UniProtKB:P26373}.
CC   -!- SUBUNIT: Component of the 60S large ribosomal subunit (LSU).
CC       {ECO:0000250|UniProtKB:P26373}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P26373}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=a;
CC         IsoId=P91128-1; Sequence=Displayed;
CC       Name=b;
CC         IsoId=P91128-2; Sequence=VSP_020726;
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL13 family.
CC       {ECO:0000305}.
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DR   EMBL; FO080749; CCD66399.1; -; Genomic_DNA.
DR   EMBL; FO080749; CCD66400.1; -; Genomic_DNA.
DR   PIR; T25599; T25599.
DR   RefSeq; NP_001021017.1; NM_001025846.3. [P91128-1]
DR   AlphaFoldDB; P91128; -.
DR   SMR; P91128; -.
DR   BioGRID; 37423; 97.
DR   DIP; DIP-25306N; -.
DR   STRING; 6239.C32E8.2a; -.
DR   iPTMnet; P91128; -.
DR   EPD; P91128; -.
DR   PaxDb; P91128; -.
DR   PeptideAtlas; P91128; -.
DR   PRIDE; P91128; -.
DR   EnsemblMetazoa; C32E8.2a.1; C32E8.2a.1; WBGene00004425. [P91128-1]
DR   GeneID; 171949; -.
DR   KEGG; cel:CELE_C32E8.2; -.
DR   UCSC; C32E8.2a.1; c. elegans. [P91128-1]
DR   CTD; 171949; -.
DR   WormBase; C32E8.2a; CE08526; WBGene00004425; rpl-13. [P91128-1]
DR   eggNOG; KOG3295; Eukaryota.
DR   GeneTree; ENSGT00390000007818; -.
DR   HOGENOM; CLU_075696_1_0_1; -.
DR   InParanoid; P91128; -.
DR   OMA; NQQIPHN; -.
DR   OrthoDB; 1239434at2759; -.
DR   PhylomeDB; P91128; -.
DR   Reactome; R-CEL-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-CEL-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-CEL-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   Reactome; R-CEL-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-CEL-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   Reactome; R-CEL-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-CEL-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   PRO; PR:P91128; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00004425; Expressed in larva and 4 other tissues.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   HAMAP; MF_00499; Ribosomal_L13e; 1.
DR   InterPro; IPR001380; Ribosomal_L13e.
DR   InterPro; IPR018256; Ribosomal_L13e_CS.
DR   PANTHER; PTHR11722; PTHR11722; 1.
DR   Pfam; PF01294; Ribosomal_L13e; 1.
DR   PROSITE; PS01104; RIBOSOMAL_L13E; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Cytoplasm; Reference proteome; Ribonucleoprotein;
KW   Ribosomal protein.
FT   CHAIN           1..207
FT                   /note="60S ribosomal protein L13"
FT                   /id="PRO_0000192927"
FT   VAR_SEQ         85..203
FT                   /note="Missing (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_020726"
SQ   SEQUENCE   207 AA;  23753 MW;  5D22A55C0AC01C36 CRC64;
     MAPRGNQMLG NAHFRKHWHK RIKTWFDQPA RKLRRRQNRQ AKAVEIAPRP VAGLLRSVVR
     CPQKRYNTKT RLGRGFSLQE LKAAGISQAQ ARTIGIAVDV RRTNKTAEGL KANADRLKEY
     KAKLILFPKK ASAPKKGDSS AEELKVAAQL RGDVLPLSHT ITFDEPRQVT DAERKVEIFR
     LLRKERADKK YRGKREKRAR EAAEENK