RL13_DANRE
ID RL13_DANRE Reviewed; 211 AA.
AC Q90Z10;
DT 11-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=60S ribosomal protein L13;
GN Name=rpl13;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Miller V.M., Rebagliati M.R., Paulson H.L.;
RT "Molecular cloning of the zebrafish 60S ribosomal protein L13 (Breast basic
RT conserved protein 1 homolog).";
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15138505; DOI=10.1371/journal.pbio.0020139;
RA Amsterdam A., Sadler K.C., Lai K., Farrington S., Bronson R.T., Lees J.A.,
RA Hopkins N.;
RT "Many ribosomal protein genes are cancer genes in zebrafish.";
RL PLoS Biol. 2:690-698(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the ribosome, a large ribonucleoprotein complex
CC responsible for the synthesis of proteins in the cell. The small
CC ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the
CC encoded message by selecting cognate aminoacyl-transfer RNA (tRNA)
CC molecules. The large subunit (LSU) contains the ribosomal catalytic
CC site termed the peptidyl transferase center (PTC), which catalyzes the
CC formation of peptide bonds, thereby polymerizing the amino acids
CC delivered by tRNAs into a polypeptide chain. The nascent polypeptides
CC leave the ribosome through a tunnel in the LSU and interact with
CC protein factors that function in enzymatic processing, targeting, and
CC the membrane insertion of nascent chains at the exit of the ribosomal
CC tunnel. As part of the LSU, it is probably required for its formation
CC and the maturation of rRNAs. {ECO:0000250|UniProtKB:P26373}.
CC -!- SUBUNIT: Component of the 60S large ribosomal subunit (LSU).
CC {ECO:0000250|UniProtKB:P26373}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P26373}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL13 family.
CC {ECO:0000305}.
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DR EMBL; AF385081; AAK63073.1; -; mRNA.
DR EMBL; AY561516; AAS66969.1; -; mRNA.
DR EMBL; BC075977; AAH75977.1; -; mRNA.
DR RefSeq; NP_937786.1; NM_198143.1.
DR RefSeq; XP_005166723.1; XM_005166666.3.
DR AlphaFoldDB; Q90Z10; -.
DR SMR; Q90Z10; -.
DR STRING; 7955.ENSDARP00000047390; -.
DR PaxDb; Q90Z10; -.
DR PRIDE; Q90Z10; -.
DR Ensembl; ENSDART00000168460; ENSDARP00000132139; ENSDARG00000099380.
DR Ensembl; ENSDART00000176368; ENSDARP00000144370; ENSDARG00000099380.
DR GeneID; 378961; -.
DR KEGG; dre:378961; -.
DR CTD; 6137; -.
DR ZFIN; ZDB-GENE-031007-1; rpl13.
DR eggNOG; KOG3295; Eukaryota.
DR GeneTree; ENSGT00390000007818; -.
DR HOGENOM; CLU_075696_1_0_1; -.
DR InParanoid; Q90Z10; -.
DR OMA; NQQIPHN; -.
DR OrthoDB; 1239434at2759; -.
DR PhylomeDB; Q90Z10; -.
DR TreeFam; TF300073; -.
DR Reactome; R-DRE-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-DRE-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-DRE-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-DRE-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-DRE-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-DRE-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-DRE-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:Q90Z10; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 7.
DR Bgee; ENSDARG00000099380; Expressed in granulocyte and 27 other tissues.
DR ExpressionAtlas; Q90Z10; baseline and differential.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0051726; P:regulation of cell cycle; IMP:ZFIN.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR HAMAP; MF_00499; Ribosomal_L13e; 1.
DR InterPro; IPR001380; Ribosomal_L13e.
DR InterPro; IPR018256; Ribosomal_L13e_CS.
DR PANTHER; PTHR11722; PTHR11722; 1.
DR Pfam; PF01294; Ribosomal_L13e; 1.
DR PROSITE; PS01104; RIBOSOMAL_L13E; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..211
FT /note="60S ribosomal protein L13"
FT /id="PRO_0000192923"
SQ SEQUENCE 211 AA; 24365 MW; E32706629A5A94E6 CRC64;
MAPSRNGMIL NPHFHKDWQK RVRTWFNQPA RKIRRRKARQ AKARRIAPRP VSGPLRPVVR
CPTIRYHTKV RAGRGFTLEE LKAAGINKKV ARTIGISVDS RRRNRSTESL QANVQRLKEY
RTKLIIFPRK AAKPKKGDST EEELKMATQL TGPVMPIKKV HKKEKARVIS EDEKNFKAFA
SLRMARANAR LFGIRAKRAK EAAEQDVEKK K