ID   RL13_HCMVM              Reviewed;         293 AA.
AC   Q6SWC9; D2K3H1;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   23-FEB-2022, entry version 58.
DE   RecName: Full=Membrane protein RL13;
DE   Flags: Precursor;
GN   Name=RL13;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=20679731; DOI=10.1172/jci42955;
RA   Stanton R.J., Baluchova K., Dargan D.J., Cunningham C., Sheehy O.,
RA   Seirafian S., McSharry B.P., Neale M.L., Davies J.A., Tomasec P.,
RA   Davison A.J., Wilkinson G.W.;
RT   "Reconstruction of the complete human cytomegalovirus genome in a BAC
RT   reveals RL13 to be a potent inhibitor of replication.";
RL   J. Clin. Invest. 120:3191-3208(2010).
CC   -!- FUNCTION: May play a role in modifying tropism or in modulating cell
CC       signaling during virus entry. Since RL13 expression severely impairs
CC       HCMV replication in epithelial cell cultures, it may act as a regulator
CC       promoting persistence by suppressing the switch to fully lytic
CC       infection.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
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DR   EMBL; AY446894; AAR31567.1; -; Genomic_DNA.
DR   RefSeq; YP_081461.1; NC_006273.2.
DR   PRIDE; Q6SWC9; -.
DR   DNASU; 3077492; -.
DR   GeneID; 3077492; -.
DR   KEGG; vg:3077492; -.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   SMART; SM00409; IG; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix;
KW   Viral envelope protein; Virion.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..293
FT                   /note="Membrane protein RL13"
FT                   /id="PRO_0000417862"
FT   TRANSMEM        245..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   293 AA;  33000 MW;  4AA06E2B8B3D328D CRC64;
     MHWHLAITWT VIILTFSECY NQTCPCPCIC VNSTTVSIST SETTSKNITP TTTTNSKKTT
     SSIATTTPSL VTTGKVVSTA ASSTIISQTN RSHTSNAITT PKTRFEYNIT GYVGQEVTLN
     FTGSWNYIQW FRYGSPGWLY SSEPICTVTS NYHHTFPRGA LCFDCDMTKL LIYDLTLNDS
     GKYVVKRTRH DNQYEEACYS LTVIFANTTS IVTNRTCDRK RTENTDTTNH EIGKHIIETI
     KKANIPLGIH AVWAGIVVSV ALIALYMGNR RRPRKPRYTR LPKYDPDESW TKT