ID   RL142_PLAVT             Reviewed;         560 AA.
AC   P0CV58;
DT   18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2019, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=Secreted RxLR effector protein 142 {ECO:0000303|PubMed:29706971};
DE   Flags: Precursor;
GN   Name=RXLR142 {ECO:0000303|PubMed:29706971};
OS   Plasmopara viticola (Downy mildew of grapevine) (Botrytis viticola).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Plasmopara.
OX   NCBI_TaxID=143451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DOMAIN, FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=29706971; DOI=10.3389/fpls.2018.00286;
RA   Liu Y., Lan X., Song S., Yin L., Dry I.B., Qu J., Xiang J., Lu J.;
RT   "In planta functional analysis and subcellular localization of the oomycete
RT   pathogen Plasmopara viticola candidate RXLR effector repertoire.";
RL   Front. Plant Sci. 9:286-286(2018).
CC   -!- FUNCTION: Secreted effector that completely suppresses the host cell
CC       death induced by cell death-inducing proteins.
CC       {ECO:0000269|PubMed:29706971}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29706971}. Host
CC       nucleus {ECO:0000269|PubMed:29706971}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:29706971}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   AlphaFoldDB; P0CV58; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Host nucleus; Secreted; Signal; Virulence.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..560
FT                   /note="Secreted RxLR effector protein 142"
FT                   /id="PRO_0000447968"
FT   REGION          48..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          354..377
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           56..71
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:29706971"
FT   COMPBIAS        50..67
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        356..377
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   560 AA;  61744 MW;  5A0C016AE988EB6A CRC64;
     MRRAYFVAIA LLVAAGGKTA AGFKHNEPLH ASSSNFMASV DTVDEDLQSQ NLQESRDPKD
     DLKLSAGNEE RTPSALNNFL KEPKLLESII TAGKAMRTEG EANAIEAASK NLNQIESNKR
     QRIALTHNAV AGHRGHPSPD SDKSLMSVAN ENPLMLAESL KDQRPTAIME NAASLLKEHD
     YRLAPPESST INDKAPDGRL KNQVVTQKAV QLDKNEHVDE SFWREELVSV DQLMRLLDEF
     DKSAHPTTVN RHEESASAVA LKSSNQLESI THQRIAPTSN NVIGQVAHAP SNNVIGQVAH
     APSNNVIGQV AHAPSSLSPV LVAKNIPSIL ADRLMKKRPT AIMKNAARYL TQHINRPAPS
     GPSTNGATTS NGGLNNQLTS QKTFQLDQNK HVGDVKTFWL PTAVDRQSVP EDWADEVAKG
     PDTFSNDAVN DEVKRVHAAF LEALNLPFHQ YPQETAMMLR MVRWKKNAGP NNDITSALFK
     TLAKDHEEVL RLQDLLGPDL KKLLGDGKMA LPRNLKNLQE ALIVKLVIMY DLFFRFCYKH
     EDFVGDLPHN PSPASWILKL