RL144_PLAVT
ID RL144_PLAVT Reviewed; 274 AA.
AC P0CV60;
DT 18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT 18-SEP-2019, sequence version 1.
DT 25-MAY-2022, entry version 8.
DE RecName: Full=Secreted RxLR effector protein 144 {ECO:0000303|PubMed:29706971};
DE Flags: Precursor;
GN Name=RXLR144 {ECO:0000303|PubMed:29706971};
OS Plasmopara viticola (Downy mildew of grapevine) (Botrytis viticola).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Plasmopara.
OX NCBI_TaxID=143451;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], DOMAIN, FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=29706971; DOI=10.3389/fpls.2018.00286;
RA Liu Y., Lan X., Song S., Yin L., Dry I.B., Qu J., Xiang J., Lu J.;
RT "In planta functional analysis and subcellular localization of the oomycete
RT pathogen Plasmopara viticola candidate RXLR effector repertoire.";
RL Front. Plant Sci. 9:286-286(2018).
CC -!- FUNCTION: Secreted effector that completely suppresses the host cell
CC death induced by cell death-inducing proteins.
CC {ECO:0000269|PubMed:29706971}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29706971}. Host
CC nucleus {ECO:0000269|PubMed:29706971}. Host cytoplasm
CC {ECO:0000269|PubMed:29706971}.
CC -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC phosphate. {ECO:0000305|PubMed:29706971}.
CC -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; P0CV60; -.
DR SMR; P0CV60; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE 2: Evidence at transcript level;
KW Host cytoplasm; Host nucleus; Secreted; Signal; Virulence.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..274
FT /note="Secreted RxLR effector protein 144"
FT /id="PRO_0000447970"
FT MOTIF 49..72
FT /note="RxLR-dEER"
FT /evidence="ECO:0000305|PubMed:29706971"
SQ SEQUENCE 274 AA; 30914 MW; DAEDBE65A5F1C4F9 CRC64;
MRPWLLLLVG LSSFFALSTS VNRAKNSGSD FDLESRASTT NVHSILSKRK LRAFGGDTNT
LKDSGKARRE EKVWKLFCSV FLQLDDKKKC MFETNQVSSH QPEPRPALSF MPGPKPAHSL
VPESKPVRSL MTGNAPVRSI ATELKLVLPR ITETVKNPSK SQVVMLWLHK VADFSKSEHG
VNTMAYRTLY EWLSPSFSDA KLAKFFVGLR EDEALRETAE KMLAYMLIKS TSTEAVGRAW
LKSGEHPSRL FESMNFKEAD FKDTVFLGWL KYAS