AAPM_RHIL3
ID AAPM_RHIL3 Reviewed; 384 AA.
AC Q52814; Q1MH73;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 118.
DE RecName: Full=General L-amino acid transport system permease protein AapM;
GN Name=aapM; OrderedLocusNames=RL2202;
OS Rhizobium leguminosarum bv. viciae (strain 3841).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX NCBI_TaxID=216596;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8898392; DOI=10.1046/j.1365-2958.1996.00078.x;
RA Walshaw D.L., Poole P.S.;
RT "The general L-amino acid permease of Rhizobium leguminosarum is an ABC
RT uptake system that also influences efflux of solutes.";
RL Mol. Microbiol. 21:1239-1252(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3841;
RX PubMed=16640791; DOI=10.1186/gb-2006-7-4-r34;
RA Young J.P.W., Crossman L.C., Johnston A.W.B., Thomson N.R., Ghazoui Z.F.,
RA Hull K.H., Wexler M., Curson A.R.J., Todd J.D., Poole P.S., Mauchline T.H.,
RA East A.K., Quail M.A., Churcher C., Arrowsmith C., Cherevach I.,
RA Chillingworth T., Clarke K., Cronin A., Davis P., Fraser A., Hance Z.,
RA Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H.,
RA Rabbinowitsch E., Sanders M., Simmonds M., Whitehead S., Parkhill J.;
RT "The genome of Rhizobium leguminosarum has recognizable core and accessory
RT components.";
RL Genome Biol. 7:R34.1-R34.20(2006).
CC -!- FUNCTION: Part of a binding-protein-dependent transport system for L-
CC amino acids, affects the uptake as well as efflux of these amino acids.
CC Probably responsible for the translocation of the substrate across the
CC membrane.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. HisMQ subfamily. {ECO:0000305}.
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DR EMBL; X82596; CAA57935.1; -; Genomic_DNA.
DR EMBL; AM236080; CAK07694.1; -; Genomic_DNA.
DR RefSeq; WP_011651799.1; NC_008380.1.
DR AlphaFoldDB; Q52814; -.
DR SMR; Q52814; -.
DR STRING; 216596.RL2202; -.
DR TCDB; 3.A.1.3.8; the atp-binding cassette (abc) superfamily.
DR EnsemblBacteria; CAK07694; CAK07694; RL2202.
DR KEGG; rle:RL2202; -.
DR eggNOG; COG0765; Bacteria.
DR HOGENOM; CLU_019602_16_1_5; -.
DR OMA; LVFWVFC; -.
DR OrthoDB; 1523519at2; -.
DR Proteomes; UP000006575; Chromosome.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; -; 1.
DR InterPro; IPR010065; AA_ABC_transptr_permease_3TM.
DR InterPro; IPR043429; ArtM/GltK/GlnP/TcyL/YhdX-like.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR PANTHER; PTHR30614; PTHR30614; 1.
DR Pfam; PF00528; BPD_transp_1; 1.
DR SUPFAM; SSF161098; SSF161098; 1.
DR TIGRFAMs; TIGR01726; HEQRo_perm_3TM; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Cell inner membrane; Cell membrane; Membrane;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..384
FT /note="General L-amino acid transport system permease
FT protein AapM"
FT /id="PRO_0000059938"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 319..339
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 175..364
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ SEQUENCE 384 AA; 42150 MW; 6D4927918F60872F CRC64;
MSVADKPFVR TSILAAEPPP PGERGAVAWI RRNLLATPKD VILTILALAL IAWAVPHLVN
WLFIQAVWSG PDRTFCATTL QGGIQPDGWS GACWAFISAK YDQFIFGRYP LGERWRPAIV
GILFILLLVP MLIPSAPRKG LNAILLFAVL PVIAFWLLHG GFGLEVVETP LWGGLMVTLV
LSFVGIAVSL PVGILLALGR RSRMPVIRML CVTFIEVIRG VPLITVLFMA SVMLPLFLPT
GWNVDKLLRA LIGVSIFTSA YMAEVIRGGL QAIPKGQFEG ADSLGLGYWQ KTRLIIMPQA
IKLVIPSIVN TFIGTFKDTS LVTIIGMFDL LGIVKLNFSD ANWASAVTPI TGLIFAGFIF
WLFCFGMSRY SGFMERHLDT GHKR
