AAPP_RHIL3
ID AAPP_RHIL3 Reviewed; 257 AA.
AC Q52815; Q1MH74;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=General L-amino acid transport ATP-binding protein AapP;
GN Name=aapP; OrderedLocusNames=RL2201;
OS Rhizobium leguminosarum bv. viciae (strain 3841).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX NCBI_TaxID=216596;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8898392; DOI=10.1046/j.1365-2958.1996.00078.x;
RA Walshaw D.L., Poole P.S.;
RT "The general L-amino acid permease of Rhizobium leguminosarum is an ABC
RT uptake system that also influences efflux of solutes.";
RL Mol. Microbiol. 21:1239-1252(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3841;
RX PubMed=16640791; DOI=10.1186/gb-2006-7-4-r34;
RA Young J.P.W., Crossman L.C., Johnston A.W.B., Thomson N.R., Ghazoui Z.F.,
RA Hull K.H., Wexler M., Curson A.R.J., Todd J.D., Poole P.S., Mauchline T.H.,
RA East A.K., Quail M.A., Churcher C., Arrowsmith C., Cherevach I.,
RA Chillingworth T., Clarke K., Cronin A., Davis P., Fraser A., Hance Z.,
RA Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H.,
RA Rabbinowitsch E., Sanders M., Simmonds M., Whitehead S., Parkhill J.;
RT "The genome of Rhizobium leguminosarum has recognizable core and accessory
RT components.";
RL Genome Biol. 7:R34.1-R34.20(2006).
CC -!- FUNCTION: Part of a binding-protein-dependent transport system for L-
CC amino acids, affects the uptake as well as the efflux of these amino
CC acids. Probably responsible for energy coupling to the transport
CC system.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X82596; CAA57936.1; -; Genomic_DNA.
DR EMBL; AM236080; CAK07693.1; -; Genomic_DNA.
DR RefSeq; WP_011651798.1; NC_008380.1.
DR AlphaFoldDB; Q52815; -.
DR SMR; Q52815; -.
DR STRING; 216596.RL2201; -.
DR TCDB; 3.A.1.3.8; the atp-binding cassette (abc) superfamily.
DR PRIDE; Q52815; -.
DR EnsemblBacteria; CAK07693; CAK07693; RL2201.
DR GeneID; 67485725; -.
DR KEGG; rle:RL2201; -.
DR eggNOG; COG1126; Bacteria.
DR HOGENOM; CLU_000604_1_22_5; -.
DR OMA; APIWVRR; -.
DR OrthoDB; 1191583at2; -.
DR Proteomes; UP000006575; Chromosome.
DR GO; GO:0015424; F:ABC-type amino acid transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR030679; ABC_ATPase_HisP-typ.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 1.
DR PIRSF; PIRSF039085; ABC_ATPase_HisP; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; ATP-binding; Nucleotide-binding; Transport.
FT CHAIN 1..257
FT /note="General L-amino acid transport ATP-binding protein
FT AapP"
FT /id="PRO_0000091918"
FT DOMAIN 18..252
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 50..57
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 257 AA; 29153 MW; C4955F722D56CE9A CRC64;
MAEAPAKKLT VSATEVAVEI VNMNKWYGDF HVLRDINLKV MRGERIVIAG PSGSGKSTMI
RCINRLEEHQ KGKIVVDGTE LTNDLKKIDE VRREVGMVFQ HFNLFPHLTI LENCTLAPIW
VRKMPKKQAE EVAMHFLKRV KIPEQANKYP GQLSGGQQQR VAIARSLCMN PKIMLFDEPT
SALDPEMIKE VLDTMVGLAE EGMTMLCVTH EMGFARQVAN RVIFMDQGQI VEQNEPAAFF
DNPQHERTKL FLSQILH
