ID   AAP_AAV2S               Reviewed;         204 AA.
AC   D5SGZ8;
DT   14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT   13-JUL-2010, sequence version 1.
DT   02-JUN-2021, entry version 20.
DE   RecName: Full=Assembly activating protein AAP;
OS   Adeno-associated virus 2 (isolate Srivastava/1982) (AAV-2).
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Quintoviricetes;
OC   Piccovirales; Parvoviridae; Parvovirinae; Dependoparvovirus.
OX   NCBI_TaxID=648242;
OH   NCBI_TaxID=40674; Mammalia.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6300419; DOI=10.1128/jvi.45.2.555-564.1983;
RA   Srivastava A., Lusby E.W., Berns K.I.;
RT   "Nucleotide sequence and organization of the adeno-associated virus 2
RT   genome.";
RL   J. Virol. 45:555-564(1983).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7996133; DOI=10.1099/0022-1317-75-12-3385;
RA   Ruffing M., Heid H., Kleinschmidt J.A.;
RT   "Mutations in the carboxy terminus of adeno-associated virus 2 capsid
RT   proteins affect viral infectivity: lack of an RGD integrin-binding motif.";
RL   J. Gen. Virol. 75:3385-3392(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Berns K.I., Bohenzky R.A., Cassinotti P., Colvin D., Donahue B.A., Dull T.,
RA   Horer M., Kleinschmidt J.A., Ruffing M., Snyder R.O., Tratschin J.-D.,
RA   Weitz M.;
RL   Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=20479244; DOI=10.1073/pnas.1001673107;
RA   Sonntag F., Schmidt K., Kleinschmidt J.A.;
RT   "A viral assembly factor promotes AAV2 capsid formation in the nucleolus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:10220-10225(2010).
CC   -!- FUNCTION: Plays a role in capsid assembly. Promotes the transport of
CC       unassembled capsid proteins into the host nucleolus for capsid
CC       assembly. {ECO:0000269|PubMed:20479244}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus, host nucleolus
CC       {ECO:0000269|PubMed:20479244}.
CC   -!- MISCELLANEOUS: The protein AAP uses an unusual ACG start codon.
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DR   EMBL; J01901; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF043303; ADH10168.1; -; Genomic_DNA.
DR   RefSeq; YP_004030758.1; NC_001401.2.
DR   DNASU; 4192015; -.
DR   GeneID; 4192015; -.
DR   Proteomes; UP000008469; Genome.
DR   Proteomes; UP000180764; Genome.
DR   GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell.
PE   4: Predicted;
KW   Host nucleus; Reference proteome.
FT   CHAIN           1..204
FT                   /note="Assembly activating protein AAP"
FT                   /id="PRO_0000428954"
FT   REGION          59..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          118..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          172..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        118..146
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        189..204
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   204 AA;  22595 MW;  0404B03B5BFD8C31 CRC64;
     METQTQYLTP SLSDSHQQPP LVWELIRWLQ AVAHQWQTIT RAPTEWVIPR EIGIAIPHGW
     ATESSPPAPE PGPCPPTTTT STNKFPANQE PRTTITTLAT APLGGILTST DSTATFHHVT
     GKDSSTTTGD SDPRDSTSSS LTFKSKRSRR MTVRRRLPIT LPARFRCLLT RSTSSRTSSA
     RRIKDASRRS QQTSSWCHSM DTSP