ID   AAR2_BOVIN              Reviewed;         384 AA.
AC   Q08DJ7;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Protein AAR2 homolog;
DE   AltName: Full=AAR2 splicing factor homolog;
GN   Name=AAR2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Brain cortex;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the U5 snRNP complex that is required for
CC       spliceosome assembly and for pre-mRNA splicing.
CC       {ECO:0000250|UniProtKB:P32357}.
CC   -!- SUBUNIT: Interacts with PRPF8 (via RNase H homology domain) (By
CC       similarity). Component of a U5 snRNP complex that contains PRPF8 (By
CC       similarity). {ECO:0000250|UniProtKB:P32357,
CC       ECO:0000250|UniProtKB:Q9Y312}.
CC   -!- SIMILARITY: Belongs to the AAR2 family. {ECO:0000305}.
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DR   EMBL; BC123712; AAI23713.1; -; mRNA.
DR   RefSeq; XP_005214822.1; XM_005214765.2.
DR   RefSeq; XP_005214823.1; XM_005214766.3.
DR   AlphaFoldDB; Q08DJ7; -.
DR   SMR; Q08DJ7; -.
DR   STRING; 9913.ENSBTAP00000051221; -.
DR   PaxDb; Q08DJ7; -.
DR   PRIDE; Q08DJ7; -.
DR   Ensembl; ENSBTAT00000002156; ENSBTAP00000002156; ENSBTAG00000001645.
DR   Ensembl; ENSBTAT00000056876; ENSBTAP00000051221; ENSBTAG00000001645.
DR   GeneID; 533351; -.
DR   CTD; 25980; -.
DR   VEuPathDB; HostDB:ENSBTAG00000001645; -.
DR   VGNC; VGNC:25446; AAR2.
DR   eggNOG; KOG3937; Eukaryota.
DR   GeneTree; ENSGT00390000007796; -.
DR   HOGENOM; CLU_036039_0_0_1; -.
DR   InParanoid; Q08DJ7; -.
DR   OMA; TYMKYSE; -.
DR   OrthoDB; 1156337at2759; -.
DR   TreeFam; TF315089; -.
DR   Proteomes; UP000009136; Chromosome 13.
DR   Bgee; ENSBTAG00000001645; Expressed in laryngeal cartilage and 106 other tissues.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0000244; P:spliceosomal tri-snRNP complex assembly; IBA:GO_Central.
DR   CDD; cd13778; Aar2_C; 1.
DR   CDD; cd13777; Aar2_N; 1.
DR   Gene3D; 1.25.40.550; -; 1.
DR   Gene3D; 2.60.34.20; -; 1.
DR   InterPro; IPR007946; AAR2.
DR   InterPro; IPR033648; AAR2_C.
DR   InterPro; IPR038514; AAR2_C_sf.
DR   InterPro; IPR033647; Aar2_N.
DR   InterPro; IPR038516; AAR2_N_sf.
DR   PANTHER; PTHR12689; PTHR12689; 1.
DR   Pfam; PF05282; AAR2; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; mRNA processing; mRNA splicing; Reference proteome;
KW   Spliceosome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y312"
FT   CHAIN           2..384
FT                   /note="Protein AAR2 homolog"
FT                   /id="PRO_0000265090"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y312"
SQ   SEQUENCE   384 AA;  43500 MW;  D0074AB0CA9B614E CRC64;
     MAAMQMDPEL ARRLFFEGAT VVILNMPKGT EFGIDYNSWE VGPKFRGVKM IPPGIHFLHY
     SSVDKANPRE VGPRMGFFLN LQQRGLKVLR WDAAREEVDL SPAPEAEVEA MRANLQELDQ
     FLGPYPYTTL KKWISLTNFI SEATVEKLQP ESRQICAFSE VLPVLSMRHT KDRVGQNLPR
     CGAECKSYQE GLARLPEMKP RAGTEIRFSE LPTQMFPAGA TPAEITRHSM DLSYALETVL
     SKQFPCSPQD VLGELQFAFV CFLLGNVYEA FEHWKRLLNL LCRSEEAMVK HHSLYVNLIS
     ILYHQLGEIP ADFFVDIVSQ DNFLTSTLQV FFSSARSVAV DATLRQKAER FQAHLTKKFR
     WDFEAEPEDC APVVVELPDG VGTG