RL15_BACSU
ID RL15_BACSU Reviewed; 146 AA.
AC P19946;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=50S ribosomal protein L15 {ECO:0000255|HAMAP-Rule:MF_01341};
GN Name=rplO {ECO:0000255|HAMAP-Rule:MF_01341}; OrderedLocusNames=BSU01350;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2113521; DOI=10.1093/oxfordjournals.jbchem.a123093;
RA Nakamura K., Nakamura A., Takamatsu H., Yoshikawa H., Yamane K.;
RT "Cloning and characterization of a Bacillus subtilis gene homologous to E.
RT coli secY.";
RL J. Biochem. 107:603-607(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2139212; DOI=10.1093/nar/18.6.1647;
RA Yoshikawa H., Doi R.H.;
RT "Sequence of the Bacillus subtilis spectinomycin resistance gene region.";
RL Nucleic Acids Res. 18:1647-1647(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC 3610 / NRRL NRS-744 / VKM B-501;
RX PubMed=8635744; DOI=10.1016/0378-1119(95)00757-1;
RA Suh J.-W., Boylan S.A., Oh S.H., Price C.W.;
RT "Genetic and transcriptional organization of the Bacillus subtilis spc-
RT alpha region.";
RL Gene 169:17-23(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 94-146.
RC STRAIN=168;
RX PubMed=2110998; DOI=10.1111/j.1365-2958.1990.tb00597.x;
RA Suh J.-W., Boylan S.A., Thomas S.M., Dolan K.M., Oliver D.B., Price C.W.;
RT "Isolation of a secY homologue from Bacillus subtilis: evidence for a
RT common protein export pathway in eubacteria.";
RL Mol. Microbiol. 4:305-314(1990).
RN [6] {ECO:0007744|PDB:6HA1, ECO:0007744|PDB:6HA8}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS) OF 1-146 WITH AND WITHOUT
RP VIRGINIAMYCIN M.
RX PubMed=30126986; DOI=10.1073/pnas.1808535115;
RA Crowe-McAuliffe C., Graf M., Huter P., Takada H., Abdelshahid M.,
RA Novacek J., Murina V., Atkinson G.C., Hauryliuk V., Wilson D.N.;
RT "Structural basis for antibiotic resistance mediated by the Bacillus
RT subtilis ABCF ATPase VmlR.";
RL Proc. Natl. Acad. Sci. U.S.A. 115:8978-8983(2018).
CC -!- FUNCTION: Binds to the 23S rRNA. {ECO:0000255|HAMAP-Rule:MF_01341}.
CC -!- SUBUNIT: Part of the 50S ribosomal subunit.
CC {ECO:0000269|PubMed:30126986}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL15 family.
CC {ECO:0000255|HAMAP-Rule:MF_01341}.
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DR EMBL; D00619; BAA00494.1; -; Genomic_DNA.
DR EMBL; X51329; CAA35711.1; -; Genomic_DNA.
DR EMBL; L47971; AAB06818.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB11911.1; -; Genomic_DNA.
DR EMBL; M31102; AAB59117.1; -; Genomic_DNA.
DR PIR; S12682; R5BSL5.
DR RefSeq; NP_388016.1; NC_000964.3.
DR RefSeq; WP_003225819.1; NZ_JNCM01000029.1.
DR PDB; 3J3V; EM; 13.30 A; L=1-146.
DR PDB; 3J3W; EM; 10.70 A; L=1-146.
DR PDB; 3J9W; EM; 3.90 A; BO=1-146.
DR PDB; 5NJT; EM; 3.80 A; e=1-146.
DR PDB; 6HA1; EM; 3.10 A; L=1-146.
DR PDB; 6HA8; EM; 3.50 A; L=1-146.
DR PDB; 6HTQ; EM; 4.50 A; L=1-146.
DR PDB; 6PPF; EM; 3.40 A; L=1-145.
DR PDB; 6PPK; EM; 4.40 A; L=1-146.
DR PDB; 6PVK; EM; 3.40 A; L=1-145.
DR PDB; 6TNN; EM; 3.07 A; e=1-146.
DR PDB; 6TPQ; EM; 3.07 A; e=1-146.
DR PDB; 7AQC; EM; 2.99 A; L=1-146.
DR PDB; 7AQD; EM; 3.10 A; L=1-146.
DR PDB; 7AS8; EM; 2.90 A; P=1-146.
DR PDB; 7AS9; EM; 3.50 A; P=1-146.
DR PDB; 7O5B; EM; 3.33 A; i=1-146.
DR PDB; 7OPE; EM; 3.20 A; P=1-146.
DR PDB; 7QV1; EM; 3.50 A; L=1-146.
DR PDB; 7QV2; EM; 3.50 A; L=1-146.
DR PDB; 7QV3; EM; 5.14 A; L=1-146.
DR PDBsum; 3J3V; -.
DR PDBsum; 3J3W; -.
DR PDBsum; 3J9W; -.
DR PDBsum; 5NJT; -.
DR PDBsum; 6HA1; -.
DR PDBsum; 6HA8; -.
DR PDBsum; 6HTQ; -.
DR PDBsum; 6PPF; -.
DR PDBsum; 6PPK; -.
DR PDBsum; 6PVK; -.
DR PDBsum; 6TNN; -.
DR PDBsum; 6TPQ; -.
DR PDBsum; 7AQC; -.
DR PDBsum; 7AQD; -.
DR PDBsum; 7AS8; -.
DR PDBsum; 7AS9; -.
DR PDBsum; 7O5B; -.
DR PDBsum; 7OPE; -.
DR PDBsum; 7QV1; -.
DR PDBsum; 7QV2; -.
DR PDBsum; 7QV3; -.
DR AlphaFoldDB; P19946; -.
DR SMR; P19946; -.
DR IntAct; P19946; 1.
DR STRING; 224308.BSU01350; -.
DR jPOST; P19946; -.
DR PaxDb; P19946; -.
DR PRIDE; P19946; -.
DR EnsemblBacteria; CAB11911; CAB11911; BSU_01350.
DR GeneID; 50135124; -.
DR GeneID; 64301973; -.
DR GeneID; 935940; -.
DR KEGG; bsu:BSU01350; -.
DR PATRIC; fig|224308.179.peg.138; -.
DR eggNOG; COG0200; Bacteria.
DR InParanoid; P19946; -.
DR OMA; FKNINRV; -.
DR PhylomeDB; P19946; -.
DR BioCyc; BSUB:BSU01350-MON; -.
DR PRO; PR:P19946; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01341; Ribosomal_L15; 1.
DR InterPro; IPR036227; L18e/L15P_sf.
DR InterPro; IPR030878; Ribosomal_L15.
DR InterPro; IPR005749; Ribosomal_L15_bac-type.
DR InterPro; IPR001196; Ribosomal_L15_CS.
DR InterPro; IPR021131; Ribosomal_L18e/L15P.
DR PANTHER; PTHR12934; PTHR12934; 1.
DR Pfam; PF00828; Ribosomal_L27A; 1.
DR SUPFAM; SSF52080; SSF52080; 1.
DR TIGRFAMs; TIGR01071; rplO_bact; 1.
DR PROSITE; PS00475; RIBOSOMAL_L15; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW RNA-binding; rRNA-binding.
FT CHAIN 1..146
FT /note="50S ribosomal protein L15"
FT /id="PRO_0000104674"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 3..5
FT /evidence="ECO:0007829|PDB:6TPQ"
FT TURN 10..12
FT /evidence="ECO:0007829|PDB:7AQC"
FT STRAND 19..21
FT /evidence="ECO:0007829|PDB:6PVK"
FT TURN 23..26
FT /evidence="ECO:0007829|PDB:7AS8"
FT TURN 28..32
FT /evidence="ECO:0007829|PDB:7AS8"
FT STRAND 35..37
FT /evidence="ECO:0007829|PDB:7AS8"
FT TURN 38..40
FT /evidence="ECO:0007829|PDB:6TPQ"
FT STRAND 41..43
FT /evidence="ECO:0007829|PDB:6TNN"
FT STRAND 52..54
FT /evidence="ECO:0007829|PDB:6TNN"
FT HELIX 57..60
FT /evidence="ECO:0007829|PDB:7AS8"
FT STRAND 75..77
FT /evidence="ECO:0007829|PDB:7AS8"
FT HELIX 81..84
FT /evidence="ECO:0007829|PDB:7AS8"
FT STRAND 85..87
FT /evidence="ECO:0007829|PDB:7AQC"
FT HELIX 93..99
FT /evidence="ECO:0007829|PDB:7AS8"
FT STRAND 101..103
FT /evidence="ECO:0007829|PDB:6PPF"
FT STRAND 109..111
FT /evidence="ECO:0007829|PDB:7AS8"
FT STRAND 122..128
FT /evidence="ECO:0007829|PDB:7AS8"
FT HELIX 130..139
FT /evidence="ECO:0007829|PDB:7AS8"
FT STRAND 142..145
FT /evidence="ECO:0007829|PDB:7AS8"
SQ SEQUENCE 146 AA; 15383 MW; 5DB07A902B266C11 CRC64;
MKLHELKPSE GSRKTRNRVG RGIGSGNGKT AGKGHKGQNA RSGGGVRPGF EGGQMPLFQR
LPKRGFTNIN RKEYAVVNLD KLNGFAEGTE VTPELLLETG VISKLNAGVK ILGNGKLEKK
LTVKANKFSA SAKEAVEAAG GTAEVI
