ID   AAR2_MACFA              Reviewed;         384 AA.
AC   Q4R7D0;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=Protein AAR2 homolog;
DE   AltName: Full=AAR2 splicing factor homolog;
GN   Name=AAR2; ORFNames=QtsA-15573;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the U5 snRNP complex that is required for
CC       spliceosome assembly and for pre-mRNA splicing.
CC       {ECO:0000250|UniProtKB:P32357}.
CC   -!- SUBUNIT: Interacts with PRPF8 (via RNase H homology domain) (By
CC       similarity). Component of a U5 snRNP complex that contains PRPF8 (By
CC       similarity). {ECO:0000250|UniProtKB:P32357,
CC       ECO:0000250|UniProtKB:Q9Y312}.
CC   -!- SIMILARITY: Belongs to the AAR2 family. {ECO:0000305}.
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DR   EMBL; AB168889; BAE00992.1; -; mRNA.
DR   RefSeq; NP_001271712.1; NM_001284783.1.
DR   AlphaFoldDB; Q4R7D0; -.
DR   SMR; Q4R7D0; -.
DR   STRING; 9541.XP_005568967.1; -.
DR   GeneID; 101865905; -.
DR   CTD; 25980; -.
DR   eggNOG; KOG3937; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   CDD; cd13778; Aar2_C; 1.
DR   CDD; cd13777; Aar2_N; 1.
DR   Gene3D; 1.25.40.550; -; 1.
DR   Gene3D; 2.60.34.20; -; 1.
DR   InterPro; IPR007946; AAR2.
DR   InterPro; IPR033648; AAR2_C.
DR   InterPro; IPR038514; AAR2_C_sf.
DR   InterPro; IPR033647; Aar2_N.
DR   InterPro; IPR038516; AAR2_N_sf.
DR   PANTHER; PTHR12689; PTHR12689; 1.
DR   Pfam; PF05282; AAR2; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; mRNA processing; mRNA splicing; Reference proteome;
KW   Spliceosome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y312"
FT   CHAIN           2..384
FT                   /note="Protein AAR2 homolog"
FT                   /id="PRO_0000265091"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y312"
SQ   SEQUENCE   384 AA;  43363 MW;  8CACEE1188EF8DF4 CRC64;
     MAALQMDPEL AKRLFFEGAT VVILNMPKGT EFGIDCNSWE VGPKFRGVKM IPPGIHFLYY
     SSVDKANPKE VGPRMGFFLS LYQRGLTVLR WSTLREEVDL SPAPESEVEA MRANLQELDQ
     FLGPYPYATL KKWISLTNFI SEATVEKLQP ENRQICAFSD VLPVLSMKHT KDRVGQNLPR
     CGTECKSYQE GLARLPEMKP RAGTEIRFSE LPTQMFPAGA TPAEITKHSM DLSYALQTVL
     NKQFPSSPQD VLGELQFAFV CFLLGNVYEA FEHWKRLLNL LCRSEAAMVK HHTLYINLIS
     ILYHQLGEIP ADFFVDIVSQ DNFLTSTLQV FFSSACSIAV DATLRKKAEK FQAHLTKKFR
     WDFAAEPEDC APVVVELPEG TEMG