RL15_DEIRA
ID RL15_DEIRA Reviewed; 156 AA.
AC Q9RSK9;
DT 15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 125.
DE RecName: Full=50S ribosomal protein L15;
GN Name=rplO; OrderedLocusNames=DR_2115;
OS Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG
OS 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422).
OC Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae;
OC Deinococcus.
OX NCBI_TaxID=243230;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC 9279 / R1 / VKM B-1422;
RX PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA Fraser C.M.;
RT "Genome sequence of the radioresistant bacterium Deinococcus radiodurans
RT R1.";
RL Science 286:1571-1577(1999).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT, AND PROTEIN
RP SEQUENCE OF 1-5.
RC STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC 9279 / R1 / VKM B-1422;
RX PubMed=11733066; DOI=10.1016/s0092-8674(01)00546-3;
RA Harms J., Schluenzen F., Zarivach R., Bashan A., Gat S., Agmon I.,
RA Bartels H., Franceschi F., Yonath A.;
RT "High resolution structure of the large ribosomal subunit from a mesophilic
RT eubacterium.";
RL Cell 107:679-688(2001).
RN [3]
RP X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH
RP FIVE ANTIBIOTICS.
RC STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC 9279 / R1 / VKM B-1422;
RX PubMed=11677599; DOI=10.1038/35101544;
RA Schluenzen F., Zarivach R., Harms J., Bashan A., Tocilj A., Albrecht R.,
RA Yonath A., Franceschi F.;
RT "Structural basis for the interaction of antibiotics with the peptidyl
RT transferase centre in eubacteria.";
RL Nature 413:814-821(2001).
RN [4]
RP X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH
RP TRNA MIMICS.
RC STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC 9279 / R1 / VKM B-1422;
RX PubMed=12535524; DOI=10.1016/s1097-2765(03)00009-1;
RA Bashan A., Agmon I., Zarivach R., Schluenzen F., Harms J., Berisio R.,
RA Bartels H., Franceschi F., Auerbach T., Hansen H.A., Kossoy E., Kessler M.,
RA Yonath A.;
RT "Structural basis of the ribosomal machinery for peptide bond formation,
RT translocation, and nascent chain progression.";
RL Mol. Cell 11:91-102(2003).
RN [5]
RP X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH
RP MODIFIED MACROLIDE ANTIBIOTICS.
RC STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC 9279 / R1 / VKM B-1422;
RX PubMed=12623020; DOI=10.1016/s0969-2126(03)00022-4;
RA Schluenzen F., Harms J.M., Franceschi F., Hansen H.A., Bartels H.,
RA Zarivach R., Yonath A.;
RT "Structural basis for the antibiotic activity of ketolides and azalides.";
RL Structure 11:329-338(2003).
RN [6]
RP X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH
RP TROLEANDOMYCIN.
RC STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC 9279 / R1 / VKM B-1422;
RX PubMed=12665853; DOI=10.1038/nsb915;
RA Berisio R., Schluenzen F., Harms J., Bashan A., Auerbach T., Baram D.,
RA Yonath A.;
RT "Structural insight into the role of the ribosomal tunnel in cellular
RT regulation.";
RL Nat. Struct. Biol. 10:366-370(2003).
RN [7]
RP X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH
RP THE STREPTOGRAMINS QUINUPRISTIN AND DALFOPRISTIN.
RC STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC 9279 / R1 / VKM B-1422;
RX PubMed=15059283; DOI=10.1186/1741-7007-2-4;
RA Harms J.M., Schluenzen F., Fucini P., Bartels H., Yonath A.;
RT "Alterations at the peptidyl transferase centre of the ribosome induced by
RT the synergistic action of the streptogramins dalfopristin and
RT quinupristin.";
RL BMC Biol. 2:4-4(2004).
RN [8]
RP X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH
RP TIAMULIN.
RC STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC 9279 / R1 / VKM B-1422;
RX PubMed=15554968; DOI=10.1111/j.1365-2958.2004.04346.x;
RA Schluenzen F., Pyetan E., Fucini P., Yonath A., Harms J.M.;
RT "Inhibition of peptide bond formation by pleuromutilins: the structure of
RT the 50S ribosomal subunit from Deinococcus radiodurans in complex with
RT tiamulin.";
RL Mol. Microbiol. 54:1287-1294(2004).
CC -!- FUNCTION: Binds to the 23S rRNA.
CC -!- SUBUNIT: Part of the 50S ribosomal subunit. Contacts proteins L4, L21
CC and L35. {ECO:0000269|PubMed:11677599, ECO:0000269|PubMed:12535524,
CC ECO:0000269|PubMed:12623020, ECO:0000269|PubMed:12665853,
CC ECO:0000269|PubMed:15059283, ECO:0000269|PubMed:15554968}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL15 family.
CC {ECO:0000305}.
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DR EMBL; AE000513; AAF11664.1; -; Genomic_DNA.
DR PIR; F75314; F75314.
DR RefSeq; NP_295838.1; NC_001263.1.
DR RefSeq; WP_010888746.1; NZ_CP015081.1.
DR PDB; 1NKW; X-ray; 3.10 A; J=1-156.
DR PDB; 1NWX; X-ray; 3.50 A; J=1-156.
DR PDB; 1NWY; X-ray; 3.30 A; J=1-156.
DR PDB; 1SM1; X-ray; 3.42 A; J=1-156.
DR PDB; 1XBP; X-ray; 3.50 A; J=1-156.
DR PDB; 2ZJP; X-ray; 3.70 A; I=1-156.
DR PDB; 2ZJQ; X-ray; 3.30 A; I=1-156.
DR PDB; 2ZJR; X-ray; 2.91 A; I=1-156.
DR PDB; 3CF5; X-ray; 3.30 A; I=1-156.
DR PDB; 3DLL; X-ray; 3.50 A; I=1-156.
DR PDB; 3PIO; X-ray; 3.25 A; I=1-156.
DR PDB; 3PIP; X-ray; 3.45 A; I=1-156.
DR PDB; 4IO9; X-ray; 3.20 A; I=1-156.
DR PDB; 4IOA; X-ray; 3.20 A; I=1-156.
DR PDB; 4IOC; X-ray; 3.60 A; I=1-156.
DR PDB; 4U67; X-ray; 3.65 A; I=1-156.
DR PDB; 4V49; X-ray; 8.70 A; J=4-144.
DR PDB; 4V4A; X-ray; 9.50 A; J=4-144.
DR PDB; 4V4G; X-ray; 11.50 A; M=4-144.
DR PDB; 4WFN; X-ray; 3.54 A; I=1-156.
DR PDB; 5DM6; X-ray; 2.90 A; I=4-144.
DR PDB; 5DM7; X-ray; 3.00 A; I=4-144.
DR PDB; 5JVG; X-ray; 3.43 A; I=1-156.
DR PDB; 5JVH; X-ray; 3.58 A; I=1-156.
DR PDB; 7A0R; X-ray; 3.30 A; I=1-137.
DR PDB; 7A0S; X-ray; 3.22 A; I=1-137.
DR PDB; 7A18; X-ray; 3.40 A; I=1-137.
DR PDBsum; 1NKW; -.
DR PDBsum; 1NWX; -.
DR PDBsum; 1NWY; -.
DR PDBsum; 1SM1; -.
DR PDBsum; 1XBP; -.
DR PDBsum; 2ZJP; -.
DR PDBsum; 2ZJQ; -.
DR PDBsum; 2ZJR; -.
DR PDBsum; 3CF5; -.
DR PDBsum; 3DLL; -.
DR PDBsum; 3PIO; -.
DR PDBsum; 3PIP; -.
DR PDBsum; 4IO9; -.
DR PDBsum; 4IOA; -.
DR PDBsum; 4IOC; -.
DR PDBsum; 4U67; -.
DR PDBsum; 4V49; -.
DR PDBsum; 4V4A; -.
DR PDBsum; 4V4G; -.
DR PDBsum; 4WFN; -.
DR PDBsum; 5DM6; -.
DR PDBsum; 5DM7; -.
DR PDBsum; 5JVG; -.
DR PDBsum; 5JVH; -.
DR PDBsum; 7A0R; -.
DR PDBsum; 7A0S; -.
DR PDBsum; 7A18; -.
DR AlphaFoldDB; Q9RSK9; -.
DR SMR; Q9RSK9; -.
DR IntAct; Q9RSK9; 1.
DR STRING; 243230.DR_2115; -.
DR EnsemblBacteria; AAF11664; AAF11664; DR_2115.
DR KEGG; dra:DR_2115; -.
DR PATRIC; fig|243230.17.peg.2338; -.
DR eggNOG; COG0200; Bacteria.
DR HOGENOM; CLU_055188_4_0_0; -.
DR InParanoid; Q9RSK9; -.
DR OMA; FKNINRV; -.
DR OrthoDB; 1874945at2; -.
DR EvolutionaryTrace; Q9RSK9; -.
DR Proteomes; UP000002524; Chromosome I.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01341; Ribosomal_L15; 1.
DR InterPro; IPR036227; L18e/L15P_sf.
DR InterPro; IPR030878; Ribosomal_L15.
DR InterPro; IPR005749; Ribosomal_L15_bac-type.
DR InterPro; IPR001196; Ribosomal_L15_CS.
DR InterPro; IPR021131; Ribosomal_L18e/L15P.
DR PANTHER; PTHR12934; PTHR12934; 1.
DR Pfam; PF00828; Ribosomal_L27A; 1.
DR SUPFAM; SSF52080; SSF52080; 1.
DR TIGRFAMs; TIGR01071; rplO_bact; 1.
DR PROSITE; PS00475; RIBOSOMAL_L15; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding.
FT CHAIN 1..156
FT /note="50S ribosomal protein L15"
FT /id="PRO_0000104716"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT STRAND 3..5
FT /evidence="ECO:0007829|PDB:7A0S"
FT TURN 12..14
FT /evidence="ECO:0007829|PDB:2ZJR"
FT STRAND 19..21
FT /evidence="ECO:0007829|PDB:2ZJR"
FT STRAND 23..26
FT /evidence="ECO:0007829|PDB:5DM6"
FT STRAND 30..32
FT /evidence="ECO:0007829|PDB:2ZJR"
FT STRAND 34..36
FT /evidence="ECO:0007829|PDB:5DM6"
FT TURN 37..39
FT /evidence="ECO:0007829|PDB:5DM6"
FT STRAND 44..46
FT /evidence="ECO:0007829|PDB:4IO9"
FT STRAND 51..53
FT /evidence="ECO:0007829|PDB:5DM6"
FT HELIX 56..59
FT /evidence="ECO:0007829|PDB:5DM6"
FT STRAND 66..69
FT /evidence="ECO:0007829|PDB:7A0S"
FT STRAND 73..76
FT /evidence="ECO:0007829|PDB:5DM6"
FT HELIX 77..80
FT /evidence="ECO:0007829|PDB:5DM6"
FT TURN 82..84
FT /evidence="ECO:0007829|PDB:5DM6"
FT STRAND 85..89
FT /evidence="ECO:0007829|PDB:7A0R"
FT HELIX 92..97
FT /evidence="ECO:0007829|PDB:5DM6"
FT STRAND 102..104
FT /evidence="ECO:0007829|PDB:5DM7"
FT STRAND 106..109
FT /evidence="ECO:0007829|PDB:5DM6"
FT STRAND 118..120
FT /evidence="ECO:0007829|PDB:4IOA"
FT STRAND 123..125
FT /evidence="ECO:0007829|PDB:5DM6"
FT HELIX 127..134
FT /evidence="ECO:0007829|PDB:5DM6"
FT TURN 135..137
FT /evidence="ECO:0007829|PDB:5DM6"
SQ SEQUENCE 156 AA; 16860 MW; 04D58FA897437A33 CRC64;
MKLHDLKPTP GSRKDRKRVG RGPGGTDKTA GRGHKGQKSR SGAGKGAFFE GGRSRLIARL
PKRGFNNVGT TYEVVKLSQL QDLEDTTFDR DTLEAYRLVR RKNRPVKLLA SGEISRAVTV
HVDAASAAAI KAVEAAGGRV VLPEVQTQQD DAQKAE
