RL15_DROME
ID RL15_DROME Reviewed; 204 AA.
AC O17445; A8Y561; Q7PL86; Q9W5N1;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=60S ribosomal protein L15;
GN Name=RpL15; Synonyms=ZITI; ORFNames=CG17420;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Inaguma Y., Joanisse D.R., Tanguay R.M.;
RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP STRUCTURE BY ELECTRON MICROSCOPY (6.0 ANGSTROMS) OF THE 80S RIBOSOME.
RX PubMed=23636399; DOI=10.1038/nature12104;
RA Anger A.M., Armache J.P., Berninghausen O., Habeck M., Subklewe M.,
RA Wilson D.N., Beckmann R.;
RT "Structures of the human and Drosophila 80S ribosome.";
RL Nature 497:80-85(2013).
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL15 family.
CC {ECO:0000305}.
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DR EMBL; AF030251; AAB84223.1; -; mRNA.
DR EMBL; AE014296; EAA46270.1; -; Genomic_DNA.
DR EMBL; AE014296; EAA46271.1; -; Genomic_DNA.
DR EMBL; AE014296; EDP28095.1; -; Genomic_DNA.
DR EMBL; AY094841; AAM11194.1; -; mRNA.
DR RefSeq; NP_001015155.1; NM_001015155.3.
DR RefSeq; NP_001015156.1; NM_001015156.2.
DR RefSeq; NP_001104429.2; NM_001110959.3.
DR RefSeq; NP_001104430.1; NM_001110960.2.
DR RefSeq; NP_001245395.1; NM_001258466.1.
DR RefSeq; NP_001245396.1; NM_001258467.1.
DR RefSeq; NP_001245397.1; NM_001258468.1.
DR RefSeq; NP_001245398.1; NM_001258469.1.
DR PDB; 4V6W; EM; 6.00 A; CN=1-204.
DR PDB; 6XU6; EM; 3.50 A; CN=2-204.
DR PDB; 6XU7; EM; 4.90 A; CN=2-204.
DR PDB; 6XU8; EM; 3.00 A; CN=2-204.
DR PDBsum; 4V6W; -.
DR PDBsum; 6XU6; -.
DR PDBsum; 6XU7; -.
DR PDBsum; 6XU8; -.
DR AlphaFoldDB; O17445; -.
DR SMR; O17445; -.
DR BioGRID; 78043; 122.
DR DIP; DIP-17499N; -.
DR IntAct; O17445; 1.
DR STRING; 7227.FBpp0300652; -.
DR PaxDb; O17445; -.
DR PRIDE; O17445; -.
DR DNASU; 3354918; -.
DR EnsemblMetazoa; FBtr0113742; FBpp0112465; FBgn0028697.
DR EnsemblMetazoa; FBtr0113743; FBpp0112466; FBgn0028697.
DR EnsemblMetazoa; FBtr0113744; FBpp0112467; FBgn0028697.
DR EnsemblMetazoa; FBtr0301801; FBpp0291015; FBgn0028697.
DR EnsemblMetazoa; FBtr0308333; FBpp0300652; FBgn0028697.
DR EnsemblMetazoa; FBtr0308334; FBpp0300653; FBgn0028697.
DR EnsemblMetazoa; FBtr0308335; FBpp0300654; FBgn0028697.
DR EnsemblMetazoa; FBtr0308336; FBpp0300655; FBgn0028697.
DR GeneID; 3354918; -.
DR KEGG; dme:Dmel_CG17420; -.
DR CTD; 6138; -.
DR FlyBase; FBgn0028697; RpL15.
DR VEuPathDB; VectorBase:FBgn0028697; -.
DR eggNOG; KOG1678; Eukaryota.
DR GeneTree; ENSGT00910000144184; -.
DR HOGENOM; CLU_080796_0_0_1; -.
DR InParanoid; O17445; -.
DR OMA; KYMQELY; -.
DR OrthoDB; 1181691at2759; -.
DR PhylomeDB; O17445; -.
DR Reactome; R-DME-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-DME-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-DME-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-DME-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-DME-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-DME-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR SignaLink; O17445; -.
DR BioGRID-ORCS; 3354918; 1 hit in 1 CRISPR screen.
DR ChiTaRS; RpL15; fly.
DR GenomeRNAi; 3354918; -.
DR PRO; PR:O17445; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0028697; Expressed in seminal fluid secreting gland and 11 other tissues.
DR ExpressionAtlas; O17445; baseline and differential.
DR Genevisible; O17445; DM.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0022626; C:cytosolic ribosome; IDA:FlyBase.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IDA:FlyBase.
DR GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR Gene3D; 3.40.1120.10; -; 1.
DR InterPro; IPR024794; Rbsml_L15e_core_dom_sf.
DR InterPro; IPR000439; Ribosomal_L15e.
DR InterPro; IPR020925; Ribosomal_L15e_CS.
DR InterPro; IPR012678; Ribosomal_L23/L15e_core_dom_sf.
DR PANTHER; PTHR11847; PTHR11847; 1.
DR Pfam; PF00827; Ribosomal_L15e; 1.
DR SMART; SM01384; Ribosomal_L15e; 1.
DR SUPFAM; SSF54189; SSF54189; 1.
DR PROSITE; PS01194; RIBOSOMAL_L15E; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..204
FT /note="60S ribosomal protein L15"
FT /id="PRO_0000127555"
FT REGION 185..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..204
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 204 AA; 24325 MW; BEB765555EB80EAC CRC64;
MGAYRYMQEL YRKKQSDVMR YLLRIRVWQY RQLTKLHRSP RPTRPDKARR LGYRAKQGFV
IYRIRVRRGG RKRPVPKGCT YGKPKSHGVN QLKPYRGLQS IAEERVGRRL GGLRVLNSYW
IAQDASYKYF EVILIDTHHS AIRRDPKINW ICKHVHKHRE LRGLTSAGKS SRGIGKGYRY
SQTIGGSRRA AWKRKNREHM HRKR
