ID   AAR2_MOUSE              Reviewed;         384 AA.
AC   Q9D2V5; Q3TEN8; Q3TM16; Q8VBU9;
DT   19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 3.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Protein AAR2 homolog;
DE   AltName: Full=AAR2 splicing factor homolog;
GN   Name=Aar2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Kidney, Mammary gland, and Thymus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Component of the U5 snRNP complex that is required for
CC       spliceosome assembly and for pre-mRNA splicing.
CC       {ECO:0000250|UniProtKB:P32357}.
CC   -!- SUBUNIT: Interacts with PRPF8 (via RNase H homology domain) (By
CC       similarity). Component of a U5 snRNP complex that contains PRPF8 (By
CC       similarity). {ECO:0000250|UniProtKB:P32357,
CC       ECO:0000250|UniProtKB:Q9Y312}.
CC   -!- SIMILARITY: Belongs to the AAR2 family. {ECO:0000305}.
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DR   EMBL; AK018741; BAB31382.1; -; mRNA.
DR   EMBL; AK166203; BAE38626.1; -; mRNA.
DR   EMBL; AK169526; BAE41210.1; -; mRNA.
DR   EMBL; AL929153; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466551; EDL06199.1; -; Genomic_DNA.
DR   EMBL; BC019988; AAH19988.1; -; mRNA.
DR   EMBL; BC020112; AAH20112.1; -; mRNA.
DR   CCDS; CCDS16967.1; -.
DR   RefSeq; NP_001158290.1; NM_001164818.1.
DR   RefSeq; NP_080937.3; NM_026661.4.
DR   RefSeq; XP_006500160.1; XM_006500097.3.
DR   AlphaFoldDB; Q9D2V5; -.
DR   SMR; Q9D2V5; -.
DR   IntAct; Q9D2V5; 1.
DR   MINT; Q9D2V5; -.
DR   STRING; 10090.ENSMUSP00000029158; -.
DR   iPTMnet; Q9D2V5; -.
DR   PhosphoSitePlus; Q9D2V5; -.
DR   EPD; Q9D2V5; -.
DR   MaxQB; Q9D2V5; -.
DR   PaxDb; Q9D2V5; -.
DR   PRIDE; Q9D2V5; -.
DR   ProteomicsDB; 285895; -.
DR   Antibodypedia; 26501; 90 antibodies from 20 providers.
DR   DNASU; 68295; -.
DR   Ensembl; ENSMUST00000029158; ENSMUSP00000029158; ENSMUSG00000027628.
DR   Ensembl; ENSMUST00000109570; ENSMUSP00000105198; ENSMUSG00000027628.
DR   GeneID; 68295; -.
DR   KEGG; mmu:68295; -.
DR   UCSC; uc008nnp.2; mouse.
DR   CTD; 25980; -.
DR   MGI; MGI:1915545; Aar2.
DR   VEuPathDB; HostDB:ENSMUSG00000027628; -.
DR   eggNOG; KOG3937; Eukaryota.
DR   GeneTree; ENSGT00390000007796; -.
DR   HOGENOM; CLU_036039_0_0_1; -.
DR   InParanoid; Q9D2V5; -.
DR   OMA; TYMKYSE; -.
DR   OrthoDB; 1156337at2759; -.
DR   PhylomeDB; Q9D2V5; -.
DR   TreeFam; TF315089; -.
DR   BioGRID-ORCS; 68295; 9 hits in 71 CRISPR screens.
DR   ChiTaRS; Aar2; mouse.
DR   PRO; PR:Q9D2V5; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; Q9D2V5; protein.
DR   Bgee; ENSMUSG00000027628; Expressed in spermatocyte and 228 other tissues.
DR   ExpressionAtlas; Q9D2V5; baseline and differential.
DR   Genevisible; Q9D2V5; MM.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0000244; P:spliceosomal tri-snRNP complex assembly; IBA:GO_Central.
DR   CDD; cd13778; Aar2_C; 1.
DR   CDD; cd13777; Aar2_N; 1.
DR   Gene3D; 1.25.40.550; -; 1.
DR   Gene3D; 2.60.34.20; -; 1.
DR   InterPro; IPR007946; AAR2.
DR   InterPro; IPR033648; AAR2_C.
DR   InterPro; IPR038514; AAR2_C_sf.
DR   InterPro; IPR033647; Aar2_N.
DR   InterPro; IPR038516; AAR2_N_sf.
DR   PANTHER; PTHR12689; PTHR12689; 1.
DR   Pfam; PF05282; AAR2; 1.
PE   1: Evidence at protein level;
KW   mRNA processing; mRNA splicing; Reference proteome; Spliceosome.
FT   CHAIN           1..384
FT                   /note="Protein AAR2 homolog"
FT                   /id="PRO_0000209707"
FT   CONFLICT        166
FT                   /note="F -> S (in Ref. 1; BAE38626 and 4; AAH19988/
FT                   AAH20112)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   384 AA;  43408 MW;  672FEC1DFDE3630F CRC64;
     MSSMQMDPEL AKQLFFEGAT VVILNMPKGT EFGIDYNSWE VGPKFRGVKM IPPGIHFLYY
     SSVDKANPRE VGPRMGFFLS LKQRGLTVLR WNAVQEEVDL SPAPEAEVEA MRANLPDLDQ
     FLGPYPYATL KKWISLTNFI SEATMEKLQP ESRQICAFSD VLPVLFMKHT KDRVGQNLPL
     CGTECRSYQE GLARLPEMRP RAGTEIRFSE LPTQMFPAGA TPAEITRHSM DLSYALETVL
     SKQFPGNPQD VLGELQFAFV CFLLGNVYEA FEHWKRLLNL LCRSESAMGK YHALYISLIS
     ILYHQLGEIP ADFFVDIVSQ DNFLTSTLQV FFSSACSIAV EATLRKKAEK FQAHLTKKFR
     WDFTSEPEDC APVVVELPEG IETA