ID   AAR2_PONAB              Reviewed;         384 AA.
AC   Q5R5N9;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Protein AAR2 homolog;
DE   AltName: Full=AAR2 splicing factor homolog;
GN   Name=AAR2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the U5 snRNP complex that is required for
CC       spliceosome assembly and for pre-mRNA splicing.
CC       {ECO:0000250|UniProtKB:P32357}.
CC   -!- SUBUNIT: Interacts with PRPF8 (via RNase H homology domain) (By
CC       similarity). Component of a U5 snRNP complex that contains PRPF8 (By
CC       similarity). {ECO:0000250|UniProtKB:P32357,
CC       ECO:0000250|UniProtKB:Q9Y312}.
CC   -!- SIMILARITY: Belongs to the AAR2 family. {ECO:0000305}.
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DR   EMBL; CR860818; CAH92927.1; -; mRNA.
DR   RefSeq; NP_001127605.1; NM_001134133.1.
DR   AlphaFoldDB; Q5R5N9; -.
DR   SMR; Q5R5N9; -.
DR   STRING; 9601.ENSPPYP00000012249; -.
DR   GeneID; 100174684; -.
DR   KEGG; pon:100174684; -.
DR   CTD; 25980; -.
DR   eggNOG; KOG3937; Eukaryota.
DR   InParanoid; Q5R5N9; -.
DR   OrthoDB; 1156337at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   CDD; cd13778; Aar2_C; 1.
DR   CDD; cd13777; Aar2_N; 1.
DR   Gene3D; 1.25.40.550; -; 1.
DR   Gene3D; 2.60.34.20; -; 1.
DR   InterPro; IPR007946; AAR2.
DR   InterPro; IPR033648; AAR2_C.
DR   InterPro; IPR038514; AAR2_C_sf.
DR   InterPro; IPR033647; Aar2_N.
DR   InterPro; IPR038516; AAR2_N_sf.
DR   PANTHER; PTHR12689; PTHR12689; 1.
DR   Pfam; PF05282; AAR2; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; mRNA processing; mRNA splicing; Reference proteome;
KW   Spliceosome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y312"
FT   CHAIN           2..384
FT                   /note="Protein AAR2 homolog"
FT                   /id="PRO_0000265092"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y312"
SQ   SEQUENCE   384 AA;  43522 MW;  AE40EAB5C56C0100 CRC64;
     MAAMQMDPEL AKRLFFEGAT VVILNMPRGT EFGIDYNSWE VGPKFRGVKT IPPGIHFLHY
     SSVDKANPKE VGPRMGFFLS LHQRGLTVLR WSTLREEVDL SPAPESEVEA MRANLQELDQ
     FLGPYPYATL KKWISLTNFI SEATVEKLQP ENRQICAFSD VLPVLSMKHT KDRMGQNLPR
     CGTECKSYQE GLARLPEMKP RAGTEIRFSE LPTQMFPEGA TPAEITKHSM DLSYALETVL
     NKQFPSSPQD VLGELQFAFV CFLLGNVYEA FEHWKRLLNL LCRSEAAMMK HHTLYINLIS
     ILYHQLGEIP ADFFVDIVSQ DNFLTSTLQV FFSSACSIAV DATLRKKAEK FQAHLTKKFR
     WDFAAEPEDC APVVVELPEG IEMG