AAR2_RABIT
ID AAR2_RABIT Reviewed; 337 AA.
AC O77682;
DT 19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2002, sequence version 2.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=Protein AAR2 homolog;
DE AltName: Full=AAR2 splicing factor homolog;
GN Name=AAR2;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Cornea;
RA Shepard A.R., Rae J.L.;
RL Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the U5 snRNP complex that is required for
CC spliceosome assembly and for pre-mRNA splicing.
CC {ECO:0000250|UniProtKB:P32357}.
CC -!- SUBUNIT: Interacts with PRPF8 (via RNase H homology domain) (By
CC similarity). Component of a U5 snRNP complex that contains PRPF8 (By
CC similarity). {ECO:0000250|UniProtKB:P32357,
CC ECO:0000250|UniProtKB:Q9Y312}.
CC -!- SIMILARITY: Belongs to the AAR2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC29430.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF078806; AAC29430.1; ALT_INIT; mRNA.
DR AlphaFoldDB; O77682; -.
DR InParanoid; O77682; -.
DR Proteomes; UP000001811; Unplaced.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd13778; Aar2_C; 1.
DR CDD; cd13777; Aar2_N; 1.
DR Gene3D; 1.25.40.550; -; 1.
DR Gene3D; 2.60.34.20; -; 2.
DR InterPro; IPR007946; AAR2.
DR InterPro; IPR033648; AAR2_C.
DR InterPro; IPR038514; AAR2_C_sf.
DR InterPro; IPR033647; Aar2_N.
DR InterPro; IPR038516; AAR2_N_sf.
DR PANTHER; PTHR12689; PTHR12689; 2.
DR Pfam; PF05282; AAR2; 2.
PE 2: Evidence at transcript level;
KW Acetylation; mRNA processing; mRNA splicing; Reference proteome;
KW Spliceosome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9Y312"
FT CHAIN 2..337
FT /note="Protein AAR2 homolog"
FT /id="PRO_0000209708"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y312"
SQ SEQUENCE 337 AA; 37802 MW; D4E3C8B63A2B34F5 CRC64;
MAAMQMDPEL AKCLFFEGAT VVILNMPKGT EFGIDYNSWE VGPKFRGVKM IPPGIHFLHY
SAVDKANLQE LDQFLGPYPY ATLKKWISLT SFISEATVER LQPESRQICA FSDVLPVLAM
KHTKDRVGQN LPQCGTECKS YQEGLARLPE MKPRAGTEIR FSELPTQMFP AGATPAEITR
HSMDLSYALE MVLGRQFPGS PQDVLGELQF AFVCFLLGNV YEAFEHWKRL LNLLCRSEAA
MVKHHALYVN LISILYHQLG EIPADFFVDI VSQDNFLTST LQVFFSSACS TAVDATLRKK
AEKFQAHLTK KFRWDFAAEP EDCAPVVVEL PEGTSTG