AAR2_SCHPO
ID AAR2_SCHPO Reviewed; 346 AA.
AC Q6LA53;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=A1 cistron-splicing factor aar2;
GN Name=aar2; ORFNames=SPAC3H5.04;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-160, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: Component of the U5 snRNP complex that is required for
CC spliceosome assembly and for pre-mRNA splicing. Involved in splicing
CC pre-mRNA of the A1 cistron and other genes that are important for cell
CC growth (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the AAR2 family. {ECO:0000305}.
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DR EMBL; CU329670; CAB16590.1; -; Genomic_DNA.
DR PIR; T38750; T38750.
DR RefSeq; NP_594188.1; NM_001019612.2.
DR AlphaFoldDB; Q6LA53; -.
DR SMR; Q6LA53; -.
DR BioGRID; 280025; 3.
DR STRING; 4896.SPAC3H5.04.1; -.
DR iPTMnet; Q6LA53; -.
DR MaxQB; Q6LA53; -.
DR PaxDb; Q6LA53; -.
DR PRIDE; Q6LA53; -.
DR EnsemblFungi; SPAC3H5.04.1; SPAC3H5.04.1:pep; SPAC3H5.04.
DR GeneID; 2543611; -.
DR KEGG; spo:SPAC3H5.04; -.
DR PomBase; SPAC3H5.04; aar2.
DR VEuPathDB; FungiDB:SPAC3H5.04; -.
DR eggNOG; KOG3937; Eukaryota.
DR HOGENOM; CLU_809321_0_0_1; -.
DR InParanoid; Q6LA53; -.
DR OMA; GSSLQWH; -.
DR PhylomeDB; Q6LA53; -.
DR PRO; PR:Q6LA53; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005681; C:spliceosomal complex; NAS:PomBase.
DR GO; GO:0005682; C:U5 snRNP; ISO:PomBase.
DR GO; GO:0000244; P:spliceosomal tri-snRNP complex assembly; ISO:PomBase.
DR CDD; cd13778; Aar2_C; 1.
DR CDD; cd13777; Aar2_N; 1.
DR Gene3D; 1.25.40.550; -; 1.
DR Gene3D; 2.60.34.20; -; 1.
DR InterPro; IPR007946; AAR2.
DR InterPro; IPR033648; AAR2_C.
DR InterPro; IPR038514; AAR2_C_sf.
DR InterPro; IPR033647; Aar2_N.
DR InterPro; IPR038516; AAR2_N_sf.
DR PANTHER; PTHR12689; PTHR12689; 1.
DR Pfam; PF05282; AAR2; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..346
FT /note="A1 cistron-splicing factor aar2"
FT /id="PRO_0000339113"
FT MOD_RES 160
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 346 AA; 39225 MW; 6B725884F1E5D999 CRC64;
MSIEFVGWLN TYYVGIDQSS YEASKLPGIR NVKGGIHLFT WSPTYPAGLI SGVFAMVHED
MKYSIDFDSK SETASLQKLD VLYDENFYPF ESTKDWDLLT KFITVQDLQR IFATEGEFFY
LDTSTYVNAD LVSQDPEFSK PSRDDKLLNF AEFNLRRSWS PSATGPERSK QAIDKSFLFQ
RLVQSVWNDN PISALAELSI SFLSYSILSH YGALEHWKNM LSLLLQSYEL AETEPEFYAS
FLELFKLQLS SLSESDLETS AIFEKGVLLS CLDSLSERKV DGSFGSLVNE AIENLLKTIS
ELLNSHEEQA GLMQKGDLYS AADYEAEVHE TGDYVIDVST EEDPIH
