AARD_HUMAN
ID AARD_HUMAN Reviewed; 155 AA.
AC Q4LEZ3; A5PKU8;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Alanine and arginine-rich domain-containing protein;
GN Name=AARD; Synonyms=C8orf85;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Ishikawa S.K., Shimizu A., Yamazaki S., Asakawa S., Shimizu N.;
RT "Novel gene containing alanine and arginine rich domain on human chromosome
RT 8.";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-96.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q4LEZ3; Q7L2Z9: CENPQ; NbExp=3; IntAct=EBI-5463075, EBI-2350265;
CC Q4LEZ3; Q86XR8-3: CEP57; NbExp=3; IntAct=EBI-5463075, EBI-11752486;
CC Q4LEZ3; Q4V328: GRIPAP1; NbExp=3; IntAct=EBI-5463075, EBI-717919;
CC Q4LEZ3; Q2KHM9: KIAA0753; NbExp=3; IntAct=EBI-5463075, EBI-2805604;
CC Q4LEZ3; Q2M2I5: KRT24; NbExp=3; IntAct=EBI-5463075, EBI-2952736;
CC Q4LEZ3; Q7Z3Y8: KRT27; NbExp=6; IntAct=EBI-5463075, EBI-3044087;
CC Q4LEZ3; P61968: LMO4; NbExp=3; IntAct=EBI-5463075, EBI-2798728;
CC Q4LEZ3; O15481: MAGEB4; NbExp=3; IntAct=EBI-5463075, EBI-751857;
CC Q4LEZ3; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-5463075, EBI-741158;
CC Q4LEZ3; Q16623: STX1A; NbExp=3; IntAct=EBI-5463075, EBI-712466;
CC Q4LEZ3; P32856-2: STX2; NbExp=3; IntAct=EBI-5463075, EBI-11956649;
CC Q4LEZ3; Q13190: STX5; NbExp=3; IntAct=EBI-5463075, EBI-714206;
CC Q4LEZ3; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-5463075, EBI-1105213;
CC Q4LEZ3; Q9BZW7: TSGA10; NbExp=3; IntAct=EBI-5463075, EBI-744794;
CC Q4LEZ3; A5D8V6: VPS37C; NbExp=3; IntAct=EBI-5463075, EBI-2559305;
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DR EMBL; AB181519; BAE03184.1; -; mRNA.
DR EMBL; BC142621; AAI42622.1; -; mRNA.
DR CCDS; CCDS34935.1; -.
DR RefSeq; NP_001020528.1; NM_001025357.2.
DR AlphaFoldDB; Q4LEZ3; -.
DR SMR; Q4LEZ3; -.
DR BioGRID; 137412; 15.
DR IntAct; Q4LEZ3; 15.
DR STRING; 9606.ENSP00000367528; -.
DR GlyGen; Q4LEZ3; 1 site, 1 O-linked glycan (1 site).
DR BioMuta; AARD; -.
DR DMDM; 121944377; -.
DR MassIVE; Q4LEZ3; -.
DR PaxDb; Q4LEZ3; -.
DR PeptideAtlas; Q4LEZ3; -.
DR PRIDE; Q4LEZ3; -.
DR ProteomicsDB; 62246; -.
DR Antibodypedia; 74104; 1 antibodies from 1 providers.
DR DNASU; 441376; -.
DR Ensembl; ENST00000378279.4; ENSP00000367528.3; ENSG00000205002.4.
DR GeneID; 441376; -.
DR KEGG; hsa:441376; -.
DR MANE-Select; ENST00000378279.4; ENSP00000367528.3; NM_001025357.3; NP_001020528.1.
DR UCSC; uc003yof.4; human.
DR CTD; 441376; -.
DR GeneCards; AARD; -.
DR HGNC; HGNC:33842; AARD.
DR HPA; ENSG00000205002; Tissue enhanced (testis, urinary bladder).
DR neXtProt; NX_Q4LEZ3; -.
DR OpenTargets; ENSG00000205002; -.
DR PharmGKB; PA164717502; -.
DR VEuPathDB; HostDB:ENSG00000205002; -.
DR eggNOG; ENOG502SG9F; Eukaryota.
DR GeneTree; ENSGT00390000007815; -.
DR HOGENOM; CLU_142929_0_0_1; -.
DR InParanoid; Q4LEZ3; -.
DR OMA; SELLEMH; -.
DR OrthoDB; 1511306at2759; -.
DR PhylomeDB; Q4LEZ3; -.
DR TreeFam; TF339066; -.
DR PathwayCommons; Q4LEZ3; -.
DR SignaLink; Q4LEZ3; -.
DR BioGRID-ORCS; 441376; 14 hits in 1059 CRISPR screens.
DR GenomeRNAi; 441376; -.
DR Pharos; Q4LEZ3; Tdark.
DR PRO; PR:Q4LEZ3; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q4LEZ3; protein.
DR Bgee; ENSG00000205002; Expressed in left testis and 88 other tissues.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..155
FT /note="Alanine and arginine-rich domain-containing protein"
FT /id="PRO_0000337036"
FT VARIANT 96
FT /note="G -> R (in dbSNP:rs16889283)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_043570"
SQ SEQUENCE 155 AA; 17575 MW; 4D991ECA38D29531 CRC64;
MGPGDFRRCR ERISQGLQGL PGRAELWFPP RPACDFFGDG RSTDIQEEAL AASPLLEDLR
RRLTRAFQWA VQRAISRRVQ EAAAAAAARE EQSWTGVEAT LARLRAELVE MHFQNHQLAR
TLLDLNMKVQ QLKKEYELEI TSDSQSPKDD AANPE
