AARD_MOUSE
ID AARD_MOUSE Reviewed; 167 AA.
AC Q811W1; Q8BL45;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Alanine and arginine-rich domain-containing protein;
GN Name=Aard;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=12617826; DOI=10.1016/s1567-133x(02)00022-4;
RA Menke D.B., Page D.C.;
RT "Sexually dimorphic gene expression in the developing mouse gonad.";
RL Gene Expr. Patterns 2:359-367(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=17486547; DOI=10.1387/ijdb.062219ts;
RA Svingen T., Beverdam A., Verma P., Wilhelm D., Koopman P.;
RT "Aard is specifically up-regulated in Sertoli cells during mouse testis
RT differentiation.";
RL Int. J. Dev. Biol. 51:255-258(2007).
CC -!- TISSUE SPECIFICITY: Preferentially expressed in testis both in embryo
CC and adult. Expressed at much lower level in other tissues.
CC {ECO:0000269|PubMed:12617826, ECO:0000269|PubMed:17486547}.
CC -!- DEVELOPMENTAL STAGE: Expressed early in testis differentiation
CC specifically in Sertoli cells of the developing testis cords.
CC {ECO:0000269|PubMed:17486547}.
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DR EMBL; AY134665; AAN08616.1; -; mRNA.
DR EMBL; AK046414; BAC32717.1; -; mRNA.
DR EMBL; BC089505; AAH89505.1; -; mRNA.
DR CCDS; CCDS49603.1; -.
DR RefSeq; NP_780712.2; NM_175503.3.
DR AlphaFoldDB; Q811W1; -.
DR SMR; Q811W1; -.
DR STRING; 10090.ENSMUSP00000087479; -.
DR PaxDb; Q811W1; -.
DR PRIDE; Q811W1; -.
DR ProteomicsDB; 285625; -.
DR Antibodypedia; 74104; 1 antibodies from 1 providers.
DR Ensembl; ENSMUST00000090025; ENSMUSP00000087479; ENSMUSG00000068522.
DR GeneID; 239435; -.
DR KEGG; mmu:239435; -.
DR UCSC; uc029spb.1; mouse.
DR CTD; 441376; -.
DR MGI; MGI:2181621; Aard.
DR VEuPathDB; HostDB:ENSMUSG00000068522; -.
DR eggNOG; ENOG502SG9F; Eukaryota.
DR GeneTree; ENSGT00390000007815; -.
DR HOGENOM; CLU_142929_0_0_1; -.
DR InParanoid; Q811W1; -.
DR OMA; SELLEMH; -.
DR OrthoDB; 1511306at2759; -.
DR PhylomeDB; Q811W1; -.
DR TreeFam; TF339066; -.
DR BioGRID-ORCS; 239435; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Aard; mouse.
DR PRO; PR:Q811W1; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q811W1; protein.
DR Bgee; ENSMUSG00000068522; Expressed in gonadal ridge and 152 other tissues.
DR Genevisible; Q811W1; MM.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..167
FT /note="Alanine and arginine-rich domain-containing protein"
FT /id="PRO_0000337037"
FT REGION 140..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 71
FT /note="Q -> H (in Ref. 2; BAC32717)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 167 AA; 18923 MW; 50B5247D3B04F537 CRC64;
MGLGDYSHCR QRMSRGLYGV SGRAALWSPV FHPVHRMPCG TWRIGIEVPE HVRASSPVLE
HLRRQLERAF QRAAARGRAR RAREAVAAVA AAAAAAREER SRTRMECALA RLRAELLELR
FQNHQLARTL LDLNMKMQQL KKRQDQELAS KPQSPQDKEM NSECGSA
