RL17_RAT
ID RL17_RAT Reviewed; 184 AA.
AC P24049; Q4G093;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=60S ribosomal protein L17;
DE AltName: Full=Amino acid starvation-induced protein;
DE Short=ASI;
DE AltName: Full=L23;
GN Name=Rpl17;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Liver;
RX PubMed=2069571; DOI=10.1016/0006-291x(91)91817-v;
RA Suzuki K., Wool I.G.;
RT "The primary structure of rat ribosomal protein L17.";
RL Biochem. Biophys. Res. Commun. 178:322-328(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Liver;
RX PubMed=1894596; DOI=10.1016/s0021-9258(19)47324-9;
RA Laine R.O., Laipis P.J., Shay N.F., Kilberg M.S.;
RT "Identification of an amino acid-regulated mRNA from rat liver as the
RT mammalian equivalent of bacterial ribosomal protein L22.";
RL J. Biol. Chem. 266:16969-16972(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 65-184.
RC STRAIN=Sprague-Dawley; TISSUE=Liver;
RX PubMed=2211664; DOI=10.1016/s0021-9258(18)38240-1;
RA Shay N.F., Nick H.S., Kilberg M.S.;
RT "Molecular cloning of an amino acid-regulated mRNA (amino acid starvation-
RT induced) in rat hepatoma cells.";
RL J. Biol. Chem. 265:17844-17848(1990).
CC -!- FUNCTION: Component of the large ribosomal subunit. The ribosome is a
CC large ribonucleoprotein complex responsible for the synthesis of
CC proteins in the cell. {ECO:0000250|UniProtKB:P18621}.
CC -!- SUBUNIT: Component of the large ribosomal subunit.
CC {ECO:0000250|UniProtKB:P18621}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P18621}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL22 family.
CC {ECO:0000305}.
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DR EMBL; X58389; CAA41278.1; -; mRNA.
DR EMBL; X60212; CAA42765.1; -; mRNA.
DR EMBL; BC098644; AAH98644.1; -; mRNA.
DR EMBL; M60478; AAA40765.1; -; mRNA.
DR PIR; JN0078; R5RT17.
DR RefSeq; NP_958818.1; NM_201415.1.
DR AlphaFoldDB; P24049; -.
DR SMR; P24049; -.
DR BioGRID; 253514; 4.
DR IntAct; P24049; 3.
DR MINT; P24049; -.
DR STRING; 10116.ENSRNOP00000025217; -.
DR jPOST; P24049; -.
DR PaxDb; P24049; -.
DR PRIDE; P24049; -.
DR Ensembl; ENSRNOT00000025217; ENSRNOP00000025217; ENSRNOG00000018680.
DR GeneID; 291434; -.
DR KEGG; rno:291434; -.
DR CTD; 6139; -.
DR RGD; 1303019; Rpl17.
DR eggNOG; KOG3353; Eukaryota.
DR GeneTree; ENSGT00950000183010; -.
DR HOGENOM; CLU_083987_0_1_1; -.
DR InParanoid; P24049; -.
DR OrthoDB; 1362349at2759; -.
DR PhylomeDB; P24049; -.
DR TreeFam; TF300042; -.
DR Reactome; R-RNO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-RNO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-RNO-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-RNO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-RNO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-RNO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:P24049; -.
DR Proteomes; UP000002494; Chromosome 18.
DR Genevisible; P24049; RN.
DR GO; GO:0031672; C:A band; IDA:RGD.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IDA:RGD.
DR GO; GO:0022626; C:cytosolic ribosome; ISO:RGD.
DR GO; GO:0005634; C:nucleus; IDA:RGD.
DR GO; GO:0005844; C:polysome; IDA:RGD.
DR GO; GO:0045202; C:synapse; ISO:RGD.
DR GO; GO:0070180; F:large ribosomal subunit rRNA binding; IDA:RGD.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:RGD.
DR GO; GO:0034198; P:cellular response to amino acid starvation; IEP:RGD.
DR GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR GO; GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IMP:RGD.
DR GO; GO:1990928; P:response to amino acid starvation; IEP:RGD.
DR CDD; cd00336; Ribosomal_L22; 1.
DR Gene3D; 3.90.470.10; -; 1.
DR HAMAP; MF_01331_A; Ribosomal_L22_A; 1.
DR InterPro; IPR001063; Ribosomal_L22.
DR InterPro; IPR018260; Ribosomal_L22/L17_CS.
DR InterPro; IPR005721; Ribosomal_L22/L17_euk/arc.
DR InterPro; IPR036394; Ribosomal_L22/L17_sf.
DR PANTHER; PTHR11593; PTHR11593; 1.
DR Pfam; PF00237; Ribosomal_L22; 1.
DR SUPFAM; SSF54843; SSF54843; 1.
DR TIGRFAMs; TIGR01038; uL22_arch_euk; 1.
DR PROSITE; PS00464; RIBOSOMAL_L22; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..184
FT /note="60S ribosomal protein L17"
FT /id="PRO_0000125334"
FT REGION 160..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..184
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 184 AA; 21397 MW; 33379CCF610D1CA0 CRC64;
MVRYSLDPEN PTKSCKSRGS NLRVHFKNTR ETAQAIKGMH IRKATKYLKD VTLKKQCVPF
RRYNGGVGRC AQAKQWGWTQ GRWPKKSAEF LLHMLKNAES NAELKGLDVD SLVIEHIQVN
KAPKMRRRTY RAHGRINPYM SSPCHIEMIL TEKEQIVPKP EEEVAQKKKI SQKKLKKQKL
MARE
