ID   RL18A_BOVIN             Reviewed;         176 AA.
AC   Q3T003;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=60S ribosomal protein L18a;
GN   Name=RPL18A;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the large ribosomal subunit. The ribosome is a
CC       large ribonucleoprotein complex responsible for the synthesis of
CC       proteins in the cell. {ECO:0000250|UniProtKB:Q02543}.
CC   -!- SUBUNIT: Component of the large ribosomal subunit. Binds IPO9 with high
CC       affinity. {ECO:0000250|UniProtKB:Q02543}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q02543}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL20 family.
CC       {ECO:0000305}.
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DR   EMBL; BC102624; AAI02625.1; -; mRNA.
DR   RefSeq; NP_001028791.1; NM_001033619.2.
DR   PDB; 6ZVK; EM; 3.49 A; 62=2-176.
DR   PDB; 7A01; EM; 3.60 A; 62=2-176.
DR   PDBsum; 6ZVK; -.
DR   PDBsum; 7A01; -.
DR   AlphaFoldDB; Q3T003; -.
DR   SMR; Q3T003; -.
DR   STRING; 9913.ENSBTAP00000021033; -.
DR   PaxDb; Q3T003; -.
DR   PeptideAtlas; Q3T003; -.
DR   PRIDE; Q3T003; -.
DR   Ensembl; ENSBTAT00000021033; ENSBTAP00000021033; ENSBTAG00000015831.
DR   GeneID; 404142; -.
DR   KEGG; bta:404142; -.
DR   CTD; 6142; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015831; -.
DR   VGNC; VGNC:34112; RPL18A.
DR   eggNOG; KOG0829; Eukaryota.
DR   GeneTree; ENSGT00390000015797; -.
DR   HOGENOM; CLU_080773_2_0_1; -.
DR   InParanoid; Q3T003; -.
DR   OMA; RFWYFMK; -.
DR   OrthoDB; 1265349at2759; -.
DR   TreeFam; TF300086; -.
DR   Reactome; R-BTA-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-BTA-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-BTA-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-BTA-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-BTA-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000015831; Expressed in granulosa cell and 106 other tissues.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   HAMAP; MF_00273; Ribosomal_L18Ae; 1.
DR   InterPro; IPR028877; 50S_L18Ae/Ribosomal_L18a/L20.
DR   InterPro; IPR023573; Ribosomal_L18a//L18Ae/LX.
DR   InterPro; IPR021138; Ribosomal_L18a/L20_eukaryotes.
DR   PANTHER; PTHR10052; PTHR10052; 1.
DR   Pfam; PF01775; Ribosomal_L18A; 1.
DR   PIRSF; PIRSF002190; Ribosomal_L18a; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Isopeptide bond; Phosphoprotein;
KW   Reference proteome; Ribonucleoprotein; Ribosomal protein; Ubl conjugation.
FT   CHAIN           1..176
FT                   /note="60S ribosomal protein L18a"
FT                   /id="PRO_0000240140"
FT   MOD_RES         63
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q02543"
FT   MOD_RES         71
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q02543"
FT   MOD_RES         76
FT                   /note="N6-succinyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P62717"
FT   MOD_RES         123
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P62717"
FT   CROSSLNK        11
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q02543"
FT   CROSSLNK        128
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q02543"
FT   CROSSLNK        170
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q02543"
SQ   SEQUENCE   176 AA;  20762 MW;  5E501C6D835BE580 CRC64;
     MKASGTLREY KVVGRCLPTP KCHTPPLYRM RIFAPNHVVA KSRFWYFVSQ LKKMKKSSGE
     IVYCGQVFEK SPLRVKNFGI WLRYDSRSGT HNMYREYRDL TTAGAVTQCY RDMGARHRAR
     AHSIQIMKVE EIAASKCRRP AVKQFHDSKI KFPLPHRVLR RQHKPRFTTK RPNTFF