ID   RL18A_DANRE             Reviewed;         176 AA.
AC   Q7ZWJ4; Q1LVB1;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=60S ribosomal protein L18a;
GN   Name=rpl18a; ORFNames=zgc:56546;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=SJD;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the large ribosomal subunit. The ribosome is a
CC       large ribonucleoprotein complex responsible for the synthesis of
CC       proteins in the cell. {ECO:0000250|UniProtKB:Q02543}.
CC   -!- SUBUNIT: Component of the large ribosomal subunit.
CC       {ECO:0000250|UniProtKB:Q02543}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q02543}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL20 family.
CC       {ECO:0000305}.
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DR   EMBL; AL928834; CAI12012.1; -; Genomic_DNA.
DR   EMBL; BX890562; CAK04577.1; -; Genomic_DNA.
DR   EMBL; BC049045; AAH49045.1; -; mRNA.
DR   RefSeq; NP_957354.1; NM_201060.1.
DR   AlphaFoldDB; Q7ZWJ4; -.
DR   SMR; Q7ZWJ4; -.
DR   STRING; 7955.ENSDARP00000038658; -.
DR   PaxDb; Q7ZWJ4; -.
DR   PRIDE; Q7ZWJ4; -.
DR   Ensembl; ENSDART00000030215; ENSDARP00000038658; ENSDARG00000025073.
DR   GeneID; 394035; -.
DR   KEGG; dre:394035; -.
DR   CTD; 6142; -.
DR   ZFIN; ZDB-GENE-040426-1071; rpl18a.
DR   eggNOG; KOG0829; Eukaryota.
DR   GeneTree; ENSGT00390000015797; -.
DR   HOGENOM; CLU_080773_2_0_1; -.
DR   InParanoid; Q7ZWJ4; -.
DR   OMA; RFWYFMK; -.
DR   OrthoDB; 1265349at2759; -.
DR   PhylomeDB; Q7ZWJ4; -.
DR   TreeFam; TF300086; -.
DR   Reactome; R-DRE-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-DRE-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-DRE-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   Reactome; R-DRE-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-DRE-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   Reactome; R-DRE-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-DRE-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   PRO; PR:Q7ZWJ4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 4.
DR   Bgee; ENSDARG00000025073; Expressed in tail bud paraxial mesoderm and 31 other tissues.
DR   ExpressionAtlas; Q7ZWJ4; baseline.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   HAMAP; MF_00273; Ribosomal_L18Ae; 1.
DR   InterPro; IPR028877; 50S_L18Ae/Ribosomal_L18a/L20.
DR   InterPro; IPR023573; Ribosomal_L18a//L18Ae/LX.
DR   InterPro; IPR021138; Ribosomal_L18a/L20_eukaryotes.
DR   PANTHER; PTHR10052; PTHR10052; 1.
DR   Pfam; PF01775; Ribosomal_L18A; 1.
DR   PIRSF; PIRSF002190; Ribosomal_L18a; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT   CHAIN           1..176
FT                   /note="60S ribosomal protein L18a"
FT                   /id="PRO_0000213928"
SQ   SEQUENCE   176 AA;  20680 MW;  4869C68CC6DCC233 CRC64;
     MKASGTLREY KVVGRLLPSV KNPAPPLYRM RIFAPNHVVA KSRFWYFVSQ LRKMKKASGE
     IVYCGLVFEK SPLKVKNFGI WLRYDSRSGT HNMYREYRDL TTSGAVTQCY RDMGARHRAR
     AHAIQIMKVQ VIAANKCRRP AIKQFHDSKI KFPLPHRVLR RQHKPRFTTK RPNTFF