RL18A_RAT
ID RL18A_RAT Reviewed; 176 AA.
AC P62718; P11249;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=60S ribosomal protein L18a;
GN Name=Rpl18a;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Liver;
RX PubMed=2541017; DOI=10.1016/0014-5793(89)81344-4;
RA Aoyama Y., Chan Y.-L., Meyuhas O., Wool I.G.;
RT "The primary structure of rat ribosomal protein L18a.";
RL FEBS Lett. 247:242-246(1989).
RN [2]
RP SEQUENCE REVISION.
RX PubMed=7654221; DOI=10.1006/bbrc.1995.2233;
RA Chan Y.-L., Olvera J., Wool I.G.;
RT "The primary structures of rat ribosomal proteins: the characterization of
RT the cDNAs for S21 and L39, corrections in the sequences of L7 and L18a, and
RT the identification of L33.";
RL Biochem. Biophys. Res. Commun. 213:1042-1050(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the large ribosomal subunit. The ribosome is a
CC large ribonucleoprotein complex responsible for the synthesis of
CC proteins in the cell. {ECO:0000250|UniProtKB:Q02543}.
CC -!- SUBUNIT: Component of the large ribosomal subunit. Binds IPO9 with high
CC affinity. {ECO:0000250|UniProtKB:Q02543}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q02543}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL20 family.
CC {ECO:0000305}.
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DR EMBL; X14181; CAA32385.1; -; mRNA.
DR EMBL; BC058498; AAH58498.1; -; mRNA.
DR PIR; JC4231; R5RT18.
DR RefSeq; NP_997675.1; NM_212510.2.
DR AlphaFoldDB; P62718; -.
DR SMR; P62718; -.
DR BioGRID; 253263; 3.
DR IntAct; P62718; 3.
DR STRING; 10116.ENSRNOP00000025421; -.
DR iPTMnet; P62718; -.
DR PhosphoSitePlus; P62718; -.
DR jPOST; P62718; -.
DR PaxDb; P62718; -.
DR PRIDE; P62718; -.
DR Ensembl; ENSRNOT00000025421; ENSRNOP00000025421; ENSRNOG00000018795.
DR GeneID; 290641; -.
DR KEGG; rno:290641; -.
DR UCSC; RGD:1302976; rat.
DR CTD; 6142; -.
DR RGD; 1302976; Rpl18a.
DR eggNOG; KOG0829; Eukaryota.
DR GeneTree; ENSGT00390000015797; -.
DR HOGENOM; CLU_080773_2_0_1; -.
DR InParanoid; P62718; -.
DR OMA; RFWYFMK; -.
DR OrthoDB; 1265349at2759; -.
DR PhylomeDB; P62718; -.
DR Reactome; R-RNO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-RNO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-RNO-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-RNO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-RNO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-RNO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:P62718; -.
DR Proteomes; UP000002494; Chromosome 16.
DR Bgee; ENSRNOG00000018795; Expressed in ovary and 20 other tissues.
DR Genevisible; P62718; RN.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IDA:RGD.
DR GO; GO:0022626; C:cytosolic ribosome; ISO:RGD.
DR GO; GO:0042788; C:polysomal ribosome; ISO:RGD.
DR GO; GO:0014069; C:postsynaptic density; IDA:SynGO.
DR GO; GO:0005840; C:ribosome; IDA:RGD.
DR GO; GO:0045202; C:synapse; IDA:SynGO.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:RGD.
DR GO; GO:0002181; P:cytoplasmic translation; ISO:RGD.
DR GO; GO:0097327; P:response to antineoplastic agent; IEP:RGD.
DR HAMAP; MF_00273; Ribosomal_L18Ae; 1.
DR InterPro; IPR028877; 50S_L18Ae/Ribosomal_L18a/L20.
DR InterPro; IPR023573; Ribosomal_L18a//L18Ae/LX.
DR InterPro; IPR021138; Ribosomal_L18a/L20_eukaryotes.
DR PANTHER; PTHR10052; PTHR10052; 1.
DR Pfam; PF01775; Ribosomal_L18A; 1.
DR PIRSF; PIRSF002190; Ribosomal_L18a; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Isopeptide bond; Phosphoprotein; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; Ubl conjugation.
FT CHAIN 1..176
FT /note="60S ribosomal protein L18a"
FT /id="PRO_0000213927"
FT MOD_RES 63
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q02543"
FT MOD_RES 71
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q02543"
FT MOD_RES 76
FT /note="N6-succinyllysine"
FT /evidence="ECO:0000250|UniProtKB:P62717"
FT MOD_RES 123
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P62717"
FT CROSSLNK 11
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q02543"
FT CROSSLNK 128
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q02543"
FT CROSSLNK 170
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q02543"
SQ SEQUENCE 176 AA; 20732 MW; 5E404D28875BE580 CRC64;
MKASGTLREY KVVGRCLPTP KCHTPPLYRM RIFAPNHVVA KSRFWYFVSQ LKKMKKSSGE
IVYCGQVFEK SPLRVKNFGI WLRYDSRSGT HNMYREYRDL TTAGAVTQCY RDMGARHRAR
AHSIQIMKVE EIAAGKCRRP AVKQFHDSKI KFPLPHRVLR RQHKPRFTTK RPNTFF
