RL18_PIG
ID RL18_PIG Reviewed; 195 AA.
AC Q95342; I3L6F1;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 28-FEB-2018, sequence version 4.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=60S ribosomal protein L18;
GN Name=RPL18;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc;
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-111.
RC TISSUE=Small intestine;
RX PubMed=8672129; DOI=10.1007/s003359900153;
RA Winteroe A.K., Fredholm M., Davies W.;
RT "Evaluation and characterization of a porcine small intestine cDNA library:
RT analysis of 839 clones.";
RL Mamm. Genome 7:509-517(1996).
RN [3] {ECO:0007744|PDB:3J7O, ECO:0007744|PDB:3J7P, ECO:0007744|PDB:3J7Q}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS), FUNCTION, SUBCELLULAR
RP LOCATION, AND SUBUNIT.
RX PubMed=24930395; DOI=10.1016/j.cell.2014.05.024;
RA Voorhees R.M., Fernandez I.S., Scheres S.H., Hegde R.S.;
RT "Structure of the mammalian ribosome-Sec61 complex to 3.4 A resolution.";
RL Cell 157:1632-1643(2014).
CC -!- FUNCTION: Component of the large ribosomal subunit.
CC {ECO:0000269|PubMed:24930395}.
CC -!- SUBUNIT: Component of the large ribosomal subunit.
CC {ECO:0000269|PubMed:24930395}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:Q07020}. Cytoplasm
CC {ECO:0000269|PubMed:24930395}. Rough endoplasmic reticulum
CC {ECO:0000269|PubMed:24930395}. Note=Detected on cytosolic polysomes (By
CC similarity). Detected in ribosomes that are associated with the rough
CC endoplasmic reticulum (PubMed:24930395). {ECO:0000250|UniProtKB:Q07020,
CC ECO:0000269|PubMed:24930395}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL18 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB03555.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AEMK02000041; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Z81178; CAB03555.1; ALT_INIT; mRNA.
DR PDB; 3J7O; EM; 3.50 A; Q=1-188.
DR PDB; 3J7P; EM; 3.50 A; Q=1-188.
DR PDB; 3J7Q; EM; 3.50 A; Q=1-188.
DR PDB; 3J7R; EM; 3.90 A; Q=1-188.
DR PDBsum; 3J7O; -.
DR PDBsum; 3J7P; -.
DR PDBsum; 3J7Q; -.
DR PDBsum; 3J7R; -.
DR AlphaFoldDB; Q95342; -.
DR SMR; Q95342; -.
DR PaxDb; Q95342; -.
DR PeptideAtlas; Q95342; -.
DR PRIDE; Q95342; -.
DR Ensembl; ENSSSCT00000091096; ENSSSCP00000066328; ENSSSCG00000025928.
DR Ensembl; ENSSSCT00015041758; ENSSSCP00015016486; ENSSSCG00015031258.
DR Ensembl; ENSSSCT00030073576; ENSSSCP00030033667; ENSSSCG00030052661.
DR Ensembl; ENSSSCT00035064919; ENSSSCP00035026284; ENSSSCG00035048718.
DR Ensembl; ENSSSCT00070055905; ENSSSCP00070047494; ENSSSCG00070027864.
DR VGNC; VGNC:109494; RPL18.
DR eggNOG; KOG1714; Eukaryota.
DR GeneTree; ENSGT00390000012976; -.
DR InParanoid; Q95342; -.
DR OMA; MSKIHRP; -.
DR TreeFam; TF300202; -.
DR Proteomes; UP000008227; Chromosome 6.
DR Proteomes; UP000314985; Chromosome 6.
DR Bgee; ENSSSCG00000025928; Expressed in forelimb bud and 44 other tissues.
DR ExpressionAtlas; Q95342; baseline and differential.
DR Genevisible; I3L6F1; SS.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0042788; C:polysomal ribosome; ISS:UniProtKB.
DR GO; GO:0005791; C:rough endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0002181; P:cytoplasmic translation; ISS:UniProtKB.
DR InterPro; IPR036227; L18e/L15P_sf.
DR InterPro; IPR021132; Ribosomal_L18/L18-A/B/e_CS.
DR InterPro; IPR000039; Ribosomal_L18e.
DR InterPro; IPR021131; Ribosomal_L18e/L15P.
DR PANTHER; PTHR10934; PTHR10934; 1.
DR Pfam; PF17135; Ribosomal_L18; 1.
DR SUPFAM; SSF52080; SSF52080; 1.
DR PROSITE; PS01106; RIBOSOMAL_L18E; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Endoplasmic reticulum; Isopeptide bond;
KW Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW Ubl conjugation.
FT CHAIN 1..195
FT /note="60S ribosomal protein L18"
FT /id="PRO_0000132771"
FT REGION 158..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..195
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 137
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q07020"
FT MOD_RES 165
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q07020"
FT CROSSLNK 126
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q07020"
FT CROSSLNK 171
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q07020"
FT CONFLICT 99
FT /note="V -> F (in Ref. 2; CAB03555)"
SQ SEQUENCE 195 AA; 22304 MW; 3EBF7CBB59270A59 CRC64;
MVFPSPLQGV DIRHNKDRKV RRKEPKSQDI YLRLLVKLYR FLARRTNSTF NQVVLKRLFM
SRTNRPPLSL SRMIRKMKLP GREGKTAVVV GTITDDVRVQ EVPKLKVCAL RVSSRARSRI
LKAGGKILTF DQLALDSPKG CGTVLLSGPR KGREVYRHFG KAPGTPHSHT KPYVRSKGRK
FERARGRRAS RGYKN
