ID   RL18_PYRFU              Reviewed;         203 AA.
AC   Q9HH80; Q7LWX7;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=50S ribosomal protein L18;
DE   AltName: Full=Large ribosomal subunit protein uL18;
DE   AltName: Full=PfL18;
GN   Name=rpl18; OrderedLocusNames=PF1805;
OS   Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=186497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND MUTAGENESIS.
RC   STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX   PubMed=11119702; DOI=10.1016/s0014-5793(00)02293-6;
RA   Furumoto H., Taguchi A., Itoh T., Morinaga T., Itoh T.;
RT   "5S rRNA binding proteins from the hyperthermophilic archaeon, Pyrococcus
RT   furiosus.";
RL   FEBS Lett. 486:195-199(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX   PubMed=10430560; DOI=10.1093/genetics/152.4.1299;
RA   Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA   DiRuggiero J., Robb F.T.;
RT   "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT   horikoshii inferred from complete genomic sequences.";
RL   Genetics 152:1299-1305(1999).
RN   [3] {ECO:0007744|PDB:4V6U}
RP   STRUCTURE BY ELECTRON MICROSCOPY (6.60 ANGSTROMS) IN THE 70S RIBOSOME, AND
RP   SUBUNIT.
RX   PubMed=23222135; DOI=10.1093/nar/gks1259;
RA   Armache J.P., Anger A.M., Marquez V., Franckenberg S., Frohlich T.,
RA   Villa E., Berninghausen O., Thomm M., Arnold G.J., Beckmann R.,
RA   Wilson D.N.;
RT   "Promiscuous behaviour of archaeal ribosomal proteins: implications for
RT   eukaryotic ribosome evolution.";
RL   Nucleic Acids Res. 41:1284-1293(2013).
CC   -!- FUNCTION: This is one of the proteins that binds and probably mediates
CC       the attachment of the 5S RNA into the large ribosomal subunit, where it
CC       forms part of the central protuberance. {ECO:0000250}.
CC   -!- SUBUNIT: Part of the 50S ribosomal subunit (PubMed:23222135). Contacts
CC       the 5S and 23S rRNAs (By similarity). {ECO:0000250,
CC       ECO:0000269|PubMed:23222135}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL18 family.
CC       {ECO:0000305}.
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DR   EMBL; AB040118; BAB13703.1; -; Genomic_DNA.
DR   EMBL; AE009950; AAL81929.1; -; Genomic_DNA.
DR   RefSeq; WP_011012946.1; NC_018092.1.
DR   PDB; 4V6U; EM; 6.60 A; BO=1-203.
DR   PDBsum; 4V6U; -.
DR   AlphaFoldDB; Q9HH80; -.
DR   SMR; Q9HH80; -.
DR   STRING; 186497.PF1805; -.
DR   EnsemblBacteria; AAL81929; AAL81929; PF1805.
DR   GeneID; 41713624; -.
DR   KEGG; pfu:PF1805; -.
DR   PATRIC; fig|186497.12.peg.1876; -.
DR   eggNOG; arCOG04088; Archaea.
DR   HOGENOM; CLU_056222_2_0_2; -.
DR   OMA; MAHGPRY; -.
DR   OrthoDB; 108717at2157; -.
DR   PhylomeDB; Q9HH80; -.
DR   Proteomes; UP000001013; Chromosome.
DR   GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR   GO; GO:0008097; F:5S rRNA binding; IEA:InterPro.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01337_A; Ribosomal_L18_A; 1.
DR   InterPro; IPR005485; Rbsml_L5_euk/L18_arc.
DR   PANTHER; PTHR23410; PTHR23410; 2.
DR   Pfam; PF17144; Ribosomal_L5e; 2.
DR   PRINTS; PR00058; RIBOSOMALL5.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW   RNA-binding; rRNA-binding.
FT   CHAIN           1..203
FT                   /note="50S ribosomal protein L18"
FT                   /id="PRO_0000131414"
FT   MUTAGEN         1..15
FT                   /note="Missing: 6-fold decrease in binding to 5S rRNA."
FT                   /evidence="ECO:0000269|PubMed:11119702"
SQ   SEQUENCE   203 AA;  23187 MW;  1EC267DCD1713528 CRC64;
     MAHGPRYRVP FRRRREGKTN YRKRLKLLKS GKPRLVVRKS LNHHIAQIIV YDPKGDRTLV
     SAHTRELIRD FGWKGHCGNT PSAYLLGLLI GYKAKQAGIE EAILDIGLHP PVRGSSVFAV
     LKGAVDAGLN VPHSPEIFPD EYRIRGEHIA EYAKMLKEQD EEKFRRQFGG YLVKGLDPEK
     LPEHFEEVKA RIIEKFEGEG ARE