RL19_DEIRA
ID RL19_DEIRA Reviewed; 166 AA.
AC Q9RWB4;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 133.
DE RecName: Full=50S ribosomal protein L19;
GN Name=rplS; OrderedLocusNames=DR_0755;
OS Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG
OS 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422).
OC Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae;
OC Deinococcus.
OX NCBI_TaxID=243230;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC 9279 / R1 / VKM B-1422;
RX PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA Fraser C.M.;
RT "Genome sequence of the radioresistant bacterium Deinococcus radiodurans
RT R1.";
RL Science 286:1571-1577(1999).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT, AND PROTEIN
RP SEQUENCE OF 1-5.
RC STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC 9279 / R1 / VKM B-1422;
RX PubMed=11733066; DOI=10.1016/s0092-8674(01)00546-3;
RA Harms J., Schluenzen F., Zarivach R., Bashan A., Gat S., Agmon I.,
RA Bartels H., Franceschi F., Yonath A.;
RT "High resolution structure of the large ribosomal subunit from a mesophilic
RT eubacterium.";
RL Cell 107:679-688(2001).
RN [3]
RP X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH
RP FIVE ANTIBIOTICS.
RC STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC 9279 / R1 / VKM B-1422;
RX PubMed=11677599; DOI=10.1038/35101544;
RA Schluenzen F., Zarivach R., Harms J., Bashan A., Tocilj A., Albrecht R.,
RA Yonath A., Franceschi F.;
RT "Structural basis for the interaction of antibiotics with the peptidyl
RT transferase centre in eubacteria.";
RL Nature 413:814-821(2001).
RN [4]
RP X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH
RP TRNA MIMICS.
RC STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC 9279 / R1 / VKM B-1422;
RX PubMed=12535524; DOI=10.1016/s1097-2765(03)00009-1;
RA Bashan A., Agmon I., Zarivach R., Schluenzen F., Harms J., Berisio R.,
RA Bartels H., Franceschi F., Auerbach T., Hansen H.A., Kossoy E., Kessler M.,
RA Yonath A.;
RT "Structural basis of the ribosomal machinery for peptide bond formation,
RT translocation, and nascent chain progression.";
RL Mol. Cell 11:91-102(2003).
RN [5]
RP X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH
RP MODIFIED MACROLIDE ANTIBIOTICS.
RC STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC 9279 / R1 / VKM B-1422;
RX PubMed=12623020; DOI=10.1016/s0969-2126(03)00022-4;
RA Schluenzen F., Harms J.M., Franceschi F., Hansen H.A., Bartels H.,
RA Zarivach R., Yonath A.;
RT "Structural basis for the antibiotic activity of ketolides and azalides.";
RL Structure 11:329-338(2003).
RN [6]
RP X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH
RP TROLEANDOMYCIN.
RC STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC 9279 / R1 / VKM B-1422;
RX PubMed=12665853; DOI=10.1038/nsb915;
RA Berisio R., Schluenzen F., Harms J., Bashan A., Auerbach T., Baram D.,
RA Yonath A.;
RT "Structural insight into the role of the ribosomal tunnel in cellular
RT regulation.";
RL Nat. Struct. Biol. 10:366-370(2003).
RN [7]
RP X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH
RP THE STREPTOGRAMINS QUINUPRISTIN AND DALFOPRISTIN.
RC STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC 9279 / R1 / VKM B-1422;
RX PubMed=15059283; DOI=10.1186/1741-7007-2-4;
RA Harms J.M., Schluenzen F., Fucini P., Bartels H., Yonath A.;
RT "Alterations at the peptidyl transferase centre of the ribosome induced by
RT the synergistic action of the streptogramins dalfopristin and
RT quinupristin.";
RL BMC Biol. 2:4-4(2004).
RN [8]
RP X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH
RP TIAMULIN.
RC STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC 9279 / R1 / VKM B-1422;
RX PubMed=15554968; DOI=10.1111/j.1365-2958.2004.04346.x;
RA Schluenzen F., Pyetan E., Fucini P., Yonath A., Harms J.M.;
RT "Inhibition of peptide bond formation by pleuromutilins: the structure of
RT the 50S ribosomal subunit from Deinococcus radiodurans in complex with
RT tiamulin.";
RL Mol. Microbiol. 54:1287-1294(2004).
CC -!- FUNCTION: This protein is located at the 30S-50S ribosomal subunit
CC interface and may play a role in the structure and function of the
CC aminoacyl-tRNA binding site (By similarity). Binds the 23S rRNA.
CC {ECO:0000250}.
CC -!- SUBUNIT: Part of the 50S ribosomal subunit. Forms a cluster with
CC proteins L3 and L14. {ECO:0000269|PubMed:11677599,
CC ECO:0000269|PubMed:12535524, ECO:0000269|PubMed:12623020,
CC ECO:0000269|PubMed:12665853, ECO:0000269|PubMed:15059283,
CC ECO:0000269|PubMed:15554968}.
CC -!- SIMILARITY: Belongs to the bacterial ribosomal protein bL19 family.
CC {ECO:0000305}.
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DR EMBL; AE000513; AAF10334.1; -; Genomic_DNA.
DR PIR; G75478; G75478.
DR RefSeq; NP_294479.1; NC_001263.1.
DR RefSeq; WP_010887401.1; NZ_CP015081.1.
DR PDB; 1NKW; X-ray; 3.10 A; N=1-166.
DR PDB; 1NWX; X-ray; 3.50 A; N=1-166.
DR PDB; 1NWY; X-ray; 3.30 A; N=1-166.
DR PDB; 1SM1; X-ray; 3.42 A; N=1-166.
DR PDB; 1XBP; X-ray; 3.50 A; N=1-166.
DR PDB; 2ZJP; X-ray; 3.70 A; M=1-166.
DR PDB; 2ZJQ; X-ray; 3.30 A; M=1-166.
DR PDB; 2ZJR; X-ray; 2.91 A; M=1-166.
DR PDB; 3CF5; X-ray; 3.30 A; M=1-166.
DR PDB; 3DLL; X-ray; 3.50 A; M=1-166.
DR PDB; 3PIO; X-ray; 3.25 A; M=1-166.
DR PDB; 3PIP; X-ray; 3.45 A; M=1-166.
DR PDB; 4IO9; X-ray; 3.20 A; M=1-166.
DR PDB; 4IOA; X-ray; 3.20 A; M=1-166.
DR PDB; 4IOC; X-ray; 3.60 A; M=1-166.
DR PDB; 4U67; X-ray; 3.65 A; M=1-166.
DR PDB; 4V49; X-ray; 8.70 A; N=2-126.
DR PDB; 4V4A; X-ray; 9.50 A; N=2-126.
DR PDB; 4V4G; X-ray; 11.50 A; Q=2-126.
DR PDB; 4WFN; X-ray; 3.54 A; M=2-166.
DR PDB; 5DM6; X-ray; 2.90 A; M=2-106.
DR PDB; 5DM7; X-ray; 3.00 A; M=2-115.
DR PDB; 5JVG; X-ray; 3.43 A; M=1-166.
DR PDB; 5JVH; X-ray; 3.58 A; M=1-166.
DR PDB; 7A0R; X-ray; 3.30 A; M=1-113.
DR PDB; 7A0S; X-ray; 3.22 A; M=1-166.
DR PDB; 7A18; X-ray; 3.40 A; M=2-119.
DR PDBsum; 1NKW; -.
DR PDBsum; 1NWX; -.
DR PDBsum; 1NWY; -.
DR PDBsum; 1SM1; -.
DR PDBsum; 1XBP; -.
DR PDBsum; 2ZJP; -.
DR PDBsum; 2ZJQ; -.
DR PDBsum; 2ZJR; -.
DR PDBsum; 3CF5; -.
DR PDBsum; 3DLL; -.
DR PDBsum; 3PIO; -.
DR PDBsum; 3PIP; -.
DR PDBsum; 4IO9; -.
DR PDBsum; 4IOA; -.
DR PDBsum; 4IOC; -.
DR PDBsum; 4U67; -.
DR PDBsum; 4V49; -.
DR PDBsum; 4V4A; -.
DR PDBsum; 4V4G; -.
DR PDBsum; 4WFN; -.
DR PDBsum; 5DM6; -.
DR PDBsum; 5DM7; -.
DR PDBsum; 5JVG; -.
DR PDBsum; 5JVH; -.
DR PDBsum; 7A0R; -.
DR PDBsum; 7A0S; -.
DR PDBsum; 7A18; -.
DR AlphaFoldDB; Q9RWB4; -.
DR SMR; Q9RWB4; -.
DR IntAct; Q9RWB4; 1.
DR STRING; 243230.DR_0755; -.
DR EnsemblBacteria; AAF10334; AAF10334; DR_0755.
DR KEGG; dra:DR_0755; -.
DR PATRIC; fig|243230.17.peg.935; -.
DR eggNOG; COG0335; Bacteria.
DR HOGENOM; CLU_103507_0_2_0; -.
DR InParanoid; Q9RWB4; -.
DR OMA; TITVYYE; -.
DR OrthoDB; 1698718at2; -.
DR EvolutionaryTrace; Q9RWB4; -.
DR Proteomes; UP000002524; Chromosome I.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR Gene3D; 2.30.30.790; -; 1.
DR HAMAP; MF_00402; Ribosomal_L19; 1.
DR InterPro; IPR038657; L19_sf.
DR InterPro; IPR001857; Ribosomal_L19.
DR InterPro; IPR018257; Ribosomal_L19_CS.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR15680; PTHR15680; 1.
DR Pfam; PF01245; Ribosomal_L19; 1.
DR PIRSF; PIRSF002191; Ribosomal_L19; 1.
DR PRINTS; PR00061; RIBOSOMALL19.
DR SUPFAM; SSF50104; SSF50104; 1.
DR TIGRFAMs; TIGR01024; rplS_bact; 1.
DR PROSITE; PS01015; RIBOSOMAL_L19; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding.
FT CHAIN 1..166
FT /note="50S ribosomal protein L19"
FT /id="PRO_0000163448"
FT HELIX 9..18
FT /evidence="ECO:0007829|PDB:5DM6"
FT STRAND 28..30
FT /evidence="ECO:0007829|PDB:7A18"
FT STRAND 32..40
FT /evidence="ECO:0007829|PDB:5DM6"
FT STRAND 41..43
FT /evidence="ECO:0007829|PDB:2ZJR"
FT STRAND 45..58
FT /evidence="ECO:0007829|PDB:5DM6"
FT HELIX 61..63
FT /evidence="ECO:0007829|PDB:5DM6"
FT STRAND 65..72
FT /evidence="ECO:0007829|PDB:5DM6"
FT STRAND 75..82
FT /evidence="ECO:0007829|PDB:5DM6"
FT STRAND 88..95
FT /evidence="ECO:0007829|PDB:5DM6"
FT STRAND 100..102
FT /evidence="ECO:0007829|PDB:5DM6"
FT HELIX 105..107
FT /evidence="ECO:0007829|PDB:2ZJR"
FT TURN 108..110
FT /evidence="ECO:0007829|PDB:7A0S"
FT STRAND 112..115
FT /evidence="ECO:0007829|PDB:7A18"
SQ SEQUENCE 166 AA; 18316 MW; 1DA8E740601FFAF9 CRC64;
MQTHIKINRG ELLRGIEQDH TRQLPDFRPG DTVRVDTKVR EGNRTRSQAF EGVVIAINGS
GSRKSFTVRK ISFGEGVERV FPFASPLVNQ VTIVERGKVR RAKLYYLREL RGKAARIKSD
RSRVMKDAAR AQQDKANASA SQAAAAQADV TVISAAPEVA PETQGE
