RL19_DICDI
ID RL19_DICDI Reviewed; 186 AA.
AC P14329; Q54TK9;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1990, sequence version 1.
DT 25-MAY-2022, entry version 123.
DE RecName: Full=60S ribosomal protein L19;
DE AltName: Full=22 kDa calmodulin-binding protein;
DE AltName: Full=Vegetative-specific protein V14;
GN Name=rpl19; Synonyms=rpgB; ORFNames=DDB_G0281565;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=AX3;
RX PubMed=2602140; DOI=10.1093/nar/17.23.9679;
RA Singleton C.K., Manning S.S., Ken R.;
RT "Primary structure and regulation of vegetative specific genes of
RT Dictyostelium discoideum.";
RL Nucleic Acids Res. 17:9679-9692(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=AX3;
RX PubMed=1744106; DOI=10.1016/s0021-9258(18)54467-7;
RA Sonnemann J., Baeuerle A., Winckler T., Mutzel R.;
RT "A ribosomal calmodulin-binding protein from Dictyostelium.";
RL J. Biol. Chem. 266:23091-23096(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [4]
RP PROTEIN SEQUENCE OF 44-52 AND 137-144, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RA Bienvenut W.V., Veltman D.M., Insall R.H.;
RL Submitted (JAN-2010) to UniProtKB.
CC -!- FUNCTION: Ribosomal protein that binds calmodulin.
CC -!- DEVELOPMENTAL STAGE: This protein is expressed in growing cells and
CC deactivated upon the initiation of development.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL19 family.
CC {ECO:0000305}.
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DR EMBL; X15383; CAA33443.1; -; Genomic_DNA.
DR EMBL; L27657; AAA33247.1; -; mRNA.
DR EMBL; AAFI02000042; EAL66544.1; -; Genomic_DNA.
DR PIR; S07561; R5DO9E.
DR RefSeq; XP_640582.1; XM_635490.1.
DR AlphaFoldDB; P14329; -.
DR SMR; P14329; -.
DR STRING; 44689.DDB0214854; -.
DR PaxDb; P14329; -.
DR EnsemblProtists; EAL66544; EAL66544; DDB_G0281565.
DR GeneID; 8623190; -.
DR KEGG; ddi:DDB_G0281565; -.
DR dictyBase; DDB_G0281565; rpl19.
DR eggNOG; KOG1696; Eukaryota.
DR HOGENOM; CLU_083919_0_1_1; -.
DR InParanoid; P14329; -.
DR OMA; NRVWIDP; -.
DR PhylomeDB; P14329; -.
DR Reactome; R-DDI-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-DDI-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-DDI-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-DDI-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-DDI-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-DDI-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:P14329; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0015934; C:large ribosomal subunit; IDA:dictyBase.
DR GO; GO:0005811; C:lipid droplet; HDA:dictyBase.
DR GO; GO:0005516; F:calmodulin binding; IDA:dictyBase.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IDA:dictyBase.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR CDD; cd01417; Ribosomal_L19e_E; 1.
DR Gene3D; 1.10.1650.10; -; 1.
DR HAMAP; MF_01475; Ribosomal_L19e; 1.
DR InterPro; IPR035970; 60S_ribosomal_L19/L19e_sf.
DR InterPro; IPR000196; Ribosomal_L19/L19e.
DR InterPro; IPR023638; Ribosomal_L19/L19e_CS.
DR InterPro; IPR015972; Ribosomal_L19/L19e_dom1.
DR InterPro; IPR033935; Ribosomal_L19_euka.
DR InterPro; IPR039547; RPL19.
DR PANTHER; PTHR10722; PTHR10722; 1.
DR Pfam; PF01280; Ribosomal_L19e; 1.
DR SMART; SM01416; Ribosomal_L19e; 1.
DR SUPFAM; SSF48140; SSF48140; 1.
DR PROSITE; PS00526; RIBOSOMAL_L19E; 1.
PE 1: Evidence at protein level;
KW Calmodulin-binding; Direct protein sequencing; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..186
FT /note="60S ribosomal protein L19"
FT /id="PRO_0000131177"
FT REGION 158..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 186 AA; 21613 MW; 44DA531D55DF24C7 CRC64;
MVSLKLQKRL AASILKCGKG RVWIDPNEIA DVAMANSRDN VRRLIATGFI MRKPVVVHSR
SRAREHNAAK RLGRHRGAGN RLGTREARLP SKILWIRRIR VLRRLLKKYR EAKKIDKHSY
RELYLKAKGN VFKNKRTLIE YIVKSKTEKL REKLIQDQAQ ARRNKNKSIK DRRAAKSAAK
EIVSSN
