RL19_ECOLI
ID RL19_ECOLI Reviewed; 115 AA.
AC P0A7K6; P02420;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=50S ribosomal protein L19;
DE AltName: Full=Large ribosomal subunit protein bL19 {ECO:0000303|PubMed:24524803};
GN Name=rplS; OrderedLocusNames=b2606, JW2587;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND OPERON STRUCTURE.
RC STRAIN=K12;
RX PubMed=6357787; DOI=10.1002/j.1460-2075.1983.tb01519.x;
RA Bystroem A.S., Hjalmarsson K.J., Wikstroem P.M., Bjoerk G.R.;
RT "The nucleotide sequence of an Escherichia coli operon containing genes for
RT the tRNA(m1G)methyltransferase, the ribosomal proteins S16 and L19 and a
RT 21-K polypeptide.";
RL EMBO J. 2:899-905(1983).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9205837; DOI=10.1093/dnares/4.2.91;
RA Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K.,
RA Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T., Oyama S.,
RA Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H.,
RA Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.;
RT "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12
RT genome corresponding to 50.0-68.8 min on the linkage map and analysis of
RT its sequence features.";
RL DNA Res. 4:91-113(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP PROTEIN SEQUENCE OF 2-115, AND SUBUNIT.
RX PubMed=339951; DOI=10.1021/bi00596a021;
RA Brosius J., Arfsten U.;
RT "Primary structure of protein L19 from the large subunit of Escherichia
RT coli ribosomes.";
RL Biochemistry 17:508-516(1978).
RN [6]
RP CROSS-LINKING TO L14.
RX PubMed=2665813; DOI=10.1021/bi00435a071;
RA Walleczek J., Martin T., Redl B., Stoeffler-Meilicke M., Stoeffler G.;
RT "Comparative cross-linking study on the 50S ribosomal subunit from
RT Escherichia coli.";
RL Biochemistry 28:4099-4105(1989).
RN [7]
RP MASS SPECTROMETRY, AND SUBUNIT.
RC STRAIN=K12 / ATCC 25404 / DSM 5698 / NCIMB 11290;
RX PubMed=10094780; DOI=10.1006/abio.1998.3077;
RA Arnold R.J., Reilly J.P.;
RT "Observation of Escherichia coli ribosomal proteins and their
RT posttranslational modifications by mass spectrometry.";
RL Anal. Biochem. 269:105-112(1999).
RN [8]
RP NOMENCLATURE.
RX PubMed=24524803; DOI=10.1016/j.sbi.2014.01.002;
RA Ban N., Beckmann R., Cate J.H.D., Dinman J.D., Dragon F., Ellis S.R.,
RA Lafontaine D.L.J., Lindahl L., Liljas A., Lipton J.M., McAlear M.A.,
RA Moore P.B., Noller H.F., Ortega J., Panse V.G., Ramakrishnan V.,
RA Spahn C.M.T., Steitz T.A., Tchorzewski M., Tollervey D., Warren A.J.,
RA Williamson J.R., Wilson D., Yonath A., Yusupov M.;
RT "A new system for naming ribosomal proteins.";
RL Curr. Opin. Struct. Biol. 24:165-169(2014).
RN [9]
RP STRUCTURE BY ELECTRON MICROSCOPY (11.50 ANGSTROMS), INTERSUBUNIT BRIDGE
RP FORMATION, AND SUBUNIT.
RC STRAIN=MRE-600;
RX PubMed=12809609; DOI=10.1016/s0092-8674(03)00427-6;
RA Gao H., Sengupta J., Valle M., Korostelev A., Eswar N., Stagg S.M.,
RA Van Roey P., Agrawal R.K., Harvey S.C., Sali A., Chapman M.S., Frank J.;
RT "Study of the structural dynamics of the E. coli 70S ribosome using real-
RT space refinement.";
RL Cell 113:789-801(2003).
RN [10]
RP X-RAY CRYSTALLOGRAPHY (3.46 ANGSTROMS) OF 2 DIFFERENT RIBOSOME STRUCTURES,
RP AND SUBUNIT.
RC STRAIN=MRE-600;
RX PubMed=16272117; DOI=10.1126/science.1117230;
RA Schuwirth B.S., Borovinskaya M.A., Hau C.W., Zhang W., Vila-Sanjurjo A.,
RA Holton J.M., Cate J.H.D.;
RT "Structures of the bacterial ribosome at 3.5 A resolution.";
RL Science 310:827-834(2005).
RN [11]
RP STRUCTURE BY ELECTRON MICROSCOPY (3.80 ANGSTROMS) OF 2-115 IN TNAC-STALLED
RP 50S RIBOSOMAL SUBUNIT, AND SUBUNIT.
RC STRAIN=K12 / A19 / KC6;
RX PubMed=25310980; DOI=10.1016/j.celrep.2014.09.011;
RA Bischoff L., Berninghausen O., Beckmann R.;
RT "Molecular basis for the ribosome functioning as an L-tryptophan sensor.";
RL Cell Rep. 9:469-475(2014).
RN [12]
RP STRUCTURE BY ELECTRON MICROSCOPY (5.5 ANGSTROMS) OF 2-115 OF 50S RIBOSOMAL
RP SUBUNIT IN COMPLEX WITH OBGE AND GMP-PNP, AND SUBUNIT.
RX PubMed=24844575; DOI=10.1371/journal.pbio.1001866;
RA Feng B., Mandava C.S., Guo Q., Wang J., Cao W., Li N., Zhang Y., Zhang Y.,
RA Wang Z., Wu J., Sanyal S., Lei J., Gao N.;
RT "Structural and functional insights into the mode of action of a
RT universally conserved Obg GTPase.";
RL PLoS Biol. 12:E1001866-E1001866(2014).
RN [13]
RP STRUCTURE BY ELECTRON MICROSCOPY (3.0 ANGSTROMS) OF 70S RIBOSOME IN COMPLEX
RP WITH ARFA AND RF2, AND SUBUNIT.
RX PubMed=27906160; DOI=10.1038/nature20822;
RA Ma C., Kurita D., Li N., Chen Y., Himeno H., Gao N.;
RT "Mechanistic insights into the alternative translation termination by ArfA
RT and RF2.";
RL Nature 541:550-553(2017).
RN [14]
RP STRUCTURE BY ELECTRON MICROSCOPY (3.1 ANGSTROMS) OF 70S RIBOSOME IN COMPLEX
RP WITH ARFA AND RF2, AND SUBUNIT.
RX PubMed=27906161; DOI=10.1038/nature20821;
RA Huter P., Mueller C., Beckert B., Arenz S., Berninghausen O., Beckmann R.,
RA Wilson D.N.;
RT "Structural basis for ArfA-RF2-mediated translation termination on mRNAs
RT lacking stop codons.";
RL Nature 541:546-549(2017).
RN [15]
RP STRUCTURE BY ELECTRON MICROSCOPY (2.97 ANGSTROMS) OF 70S RIBOSOME IN
RP COMPLEX WITH ARFA AND RF2, AND SUBUNIT.
RX PubMed=27934701; DOI=10.1126/science.aai9127;
RA James N.R., Brown A., Gordiyenko Y., Ramakrishnan V.;
RT "Translational termination without a stop codon.";
RL Science 354:1437-1440(2016).
RN [16]
RP STRUCTURE BY ELECTRON MICROSCOPY (3.52 ANGSTROMS) OF 70S RIBOSOME IN
RP COMPLEX WITH ARFA AND RF2, AND SUBUNIT.
RX PubMed=28077875; DOI=10.1038/nature21053;
RA Zeng F., Chen Y., Remis J., Shekhar M., Phillips J.C., Tajkhorshid E.,
RA Jin H.;
RT "Structural basis of co-translational quality control by ArfA and RF2 bound
RT to ribosome.";
RL Nature 541:554-557(2017).
CC -!- FUNCTION: This protein is located at the 30S-50S ribosomal subunit
CC interface. In the 70S ribosome it has been modeled to make two contacts
CC with the 16S rRNA of the 30S subunit forming part of bridges B6 and B8
CC (PubMed:12809609). In the 3.5 A resolved structures L14 and L19
CC interact and together make contact with the 16S rRNA (PubMed:16272117).
CC The protein conformation is quite different between the 50S and 70S
CC structures, which may be necessary for translocation.
CC {ECO:0000269|PubMed:12809609, ECO:0000269|PubMed:16272117}.
CC -!- SUBUNIT: Part of the 50S ribosomal subunit (PubMed:339951,
CC PubMed:10094780, PubMed:12809609, PubMed:16272117, PubMed:25310980,
CC PubMed:24844575 PubMed:27934701, PubMed:27906160, PubMed:27906161).
CC Contacts L14 (PubMed:2665813, PubMed:16272117). Forms two bridges to
CC the 30S subunit in the 70S ribosome, contacting the 16S rRNA.
CC {ECO:0000269|PubMed:10094780, ECO:0000269|PubMed:12809609,
CC ECO:0000269|PubMed:16272117, ECO:0000269|PubMed:24844575,
CC ECO:0000269|PubMed:25310980, ECO:0000269|PubMed:2665813,
CC ECO:0000269|PubMed:27906160, ECO:0000269|PubMed:27906161,
CC ECO:0000269|PubMed:27934701, ECO:0000269|PubMed:339951}.
CC -!- INDUCTION: Part of the rpsP-rimM-trmD-rplS operon.
CC {ECO:0000269|PubMed:6357787}.
CC -!- MASS SPECTROMETRY: Mass=13001.7; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:10094780};
CC -!- SIMILARITY: Belongs to the bacterial ribosomal protein bL19 family.
CC {ECO:0000305}.
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DR EMBL; X01818; CAA25960.1; -; Genomic_DNA.
DR EMBL; U00096; AAC75655.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA16491.1; -; Genomic_DNA.
DR PIR; S07951; R5EC19.
DR RefSeq; NP_417097.1; NC_000913.3.
DR RefSeq; WP_000065253.1; NZ_STEB01000040.1.
DR PDB; 2J28; EM; 8.00 A; P=2-115.
DR PDB; 2RDO; EM; 9.10 A; P=2-115.
DR PDB; 3BBX; EM; 10.00 A; P=2-115.
DR PDB; 3J5L; EM; 6.60 A; P=2-115.
DR PDB; 3J7Z; EM; 3.90 A; P=1-115.
DR PDB; 3J8G; EM; 5.00 A; P=1-115.
DR PDB; 3J9Y; EM; 3.90 A; P=1-115.
DR PDB; 3J9Z; EM; 3.60 A; LM=2-115.
DR PDB; 3JA1; EM; 3.60 A; LR=2-115.
DR PDB; 3JBU; EM; 3.64 A; p=1-115.
DR PDB; 3JBV; EM; 3.32 A; p=1-115.
DR PDB; 3JCD; EM; 3.70 A; P=1-115.
DR PDB; 3JCE; EM; 3.20 A; P=1-115.
DR PDB; 3JCJ; EM; 3.70 A; O=1-115.
DR PDB; 3JCN; EM; 4.60 A; P=1-115.
DR PDB; 4CSU; EM; 5.50 A; P=2-115.
DR PDB; 4U1U; X-ray; 2.95 A; BP/DP=2-115.
DR PDB; 4U1V; X-ray; 3.00 A; BP/DP=2-115.
DR PDB; 4U20; X-ray; 2.90 A; BP/DP=2-115.
DR PDB; 4U24; X-ray; 2.90 A; BP/DP=2-115.
DR PDB; 4U25; X-ray; 2.90 A; BP/DP=2-115.
DR PDB; 4U26; X-ray; 2.80 A; BP/DP=2-115.
DR PDB; 4U27; X-ray; 2.80 A; BP/DP=2-115.
DR PDB; 4UY8; EM; 3.80 A; P=2-115.
DR PDB; 4V47; EM; 12.30 A; AN=2-115.
DR PDB; 4V48; EM; 11.50 A; AN=2-115.
DR PDB; 4V4H; X-ray; 3.46 A; BP/DP=1-115.
DR PDB; 4V4Q; X-ray; 3.46 A; BP/DP=2-115.
DR PDB; 4V4V; EM; 15.00 A; BN=2-115.
DR PDB; 4V4W; EM; 15.00 A; BN=2-115.
DR PDB; 4V50; X-ray; 3.22 A; BP/DP=2-115.
DR PDB; 4V52; X-ray; 3.21 A; BP/DP=2-115.
DR PDB; 4V53; X-ray; 3.54 A; BP/DP=2-115.
DR PDB; 4V54; X-ray; 3.30 A; BP/DP=2-115.
DR PDB; 4V55; X-ray; 4.00 A; BP/DP=2-115.
DR PDB; 4V56; X-ray; 3.93 A; BP/DP=2-115.
DR PDB; 4V57; X-ray; 3.50 A; BP/DP=2-115.
DR PDB; 4V5B; X-ray; 3.74 A; AP/CP=2-115.
DR PDB; 4V5H; EM; 5.80 A; BP=2-115.
DR PDB; 4V5Y; X-ray; 4.45 A; BP/DP=2-115.
DR PDB; 4V64; X-ray; 3.50 A; BP/DP=2-115.
DR PDB; 4V65; EM; 9.00 A; BI=1-115.
DR PDB; 4V66; EM; 9.00 A; BI=1-115.
DR PDB; 4V69; EM; 6.70 A; BP=2-115.
DR PDB; 4V6C; X-ray; 3.19 A; BP/DP=1-115.
DR PDB; 4V6D; X-ray; 3.81 A; BP/DP=1-115.
DR PDB; 4V6E; X-ray; 3.71 A; BP/DP=1-115.
DR PDB; 4V6K; EM; 8.25 A; AQ=1-115.
DR PDB; 4V6L; EM; 13.20 A; BQ=1-115.
DR PDB; 4V6M; EM; 7.10 A; BP=2-115.
DR PDB; 4V6N; EM; 12.10 A; AR=2-115.
DR PDB; 4V6O; EM; 14.70 A; BR=2-115.
DR PDB; 4V6P; EM; 13.50 A; BR=2-115.
DR PDB; 4V6Q; EM; 11.50 A; BR=2-115.
DR PDB; 4V6R; EM; 11.50 A; BR=2-115.
DR PDB; 4V6S; EM; 13.10 A; AR=2-115.
DR PDB; 4V6T; EM; 8.30 A; BP=2-115.
DR PDB; 4V6V; EM; 9.80 A; BT=2-115.
DR PDB; 4V6Y; EM; 12.00 A; BP=1-115.
DR PDB; 4V6Z; EM; 12.00 A; BP=1-115.
DR PDB; 4V70; EM; 17.00 A; BP=1-115.
DR PDB; 4V71; EM; 20.00 A; BP=1-115.
DR PDB; 4V72; EM; 13.00 A; BP=1-115.
DR PDB; 4V73; EM; 15.00 A; BP=1-115.
DR PDB; 4V74; EM; 17.00 A; BP=1-115.
DR PDB; 4V75; EM; 12.00 A; BP=1-115.
DR PDB; 4V76; EM; 17.00 A; BP=1-115.
DR PDB; 4V77; EM; 17.00 A; BP=1-115.
DR PDB; 4V78; EM; 20.00 A; BP=1-115.
DR PDB; 4V79; EM; 15.00 A; BP=1-115.
DR PDB; 4V7A; EM; 9.00 A; BP=1-115.
DR PDB; 4V7B; EM; 6.80 A; BP=1-115.
DR PDB; 4V7C; EM; 7.60 A; BR=2-115.
DR PDB; 4V7D; EM; 7.60 A; AS=2-115.
DR PDB; 4V7I; EM; 9.60 A; AP=1-115.
DR PDB; 4V7S; X-ray; 3.25 A; BP/DP=2-115.
DR PDB; 4V7T; X-ray; 3.19 A; BP/DP=2-115.
DR PDB; 4V7U; X-ray; 3.10 A; BP/DP=2-115.
DR PDB; 4V7V; X-ray; 3.29 A; BP/DP=2-115.
DR PDB; 4V85; X-ray; 3.20 A; BT=1-115.
DR PDB; 4V89; X-ray; 3.70 A; BT=1-115.
DR PDB; 4V9C; X-ray; 3.30 A; BP/DP=1-115.
DR PDB; 4V9D; X-ray; 3.00 A; CP/DP=2-115.
DR PDB; 4V9O; X-ray; 2.90 A; AP/CP/EP/GP=1-115.
DR PDB; 4V9P; X-ray; 2.90 A; AP/CP/EP/GP=1-115.
DR PDB; 4WF1; X-ray; 3.09 A; BP/DP=2-115.
DR PDB; 4WOI; X-ray; 3.00 A; BP/CP=1-115.
DR PDB; 4WWW; X-ray; 3.10 A; RP/YP=2-115.
DR PDB; 4YBB; X-ray; 2.10 A; CQ/DQ=2-115.
DR PDB; 5ADY; EM; 4.50 A; P=1-115.
DR PDB; 5AFI; EM; 2.90 A; P=1-115.
DR PDB; 5AKA; EM; 5.70 A; P=2-115.
DR PDB; 5GAD; EM; 3.70 A; Q=1-115.
DR PDB; 5GAE; EM; 3.33 A; Q=1-115.
DR PDB; 5GAF; EM; 4.30 A; Q=2-115.
DR PDB; 5GAG; EM; 3.80 A; Q=1-115.
DR PDB; 5GAH; EM; 3.80 A; Q=1-115.
DR PDB; 5H5U; EM; 3.00 A; Q=2-115.
DR PDB; 5IQR; EM; 3.00 A; P=1-115.
DR PDB; 5IT8; X-ray; 3.12 A; CQ/DQ=2-115.
DR PDB; 5J5B; X-ray; 2.80 A; CQ/DQ=2-115.
DR PDB; 5J7L; X-ray; 3.00 A; CQ/DQ=2-115.
DR PDB; 5J88; X-ray; 3.32 A; CQ/DQ=2-115.
DR PDB; 5J8A; X-ray; 3.10 A; CQ/DQ=2-115.
DR PDB; 5J91; X-ray; 2.96 A; CQ/DQ=2-115.
DR PDB; 5JC9; X-ray; 3.03 A; CQ/DQ=2-115.
DR PDB; 5JTE; EM; 3.60 A; BP=1-115.
DR PDB; 5JU8; EM; 3.60 A; BP=1-115.
DR PDB; 5KCR; EM; 3.60 A; 1T=1-115.
DR PDB; 5KCS; EM; 3.90 A; 1T=1-115.
DR PDB; 5KPS; EM; 3.90 A; P=1-115.
DR PDB; 5KPV; EM; 4.10 A; O=1-115.
DR PDB; 5KPW; EM; 3.90 A; O=1-115.
DR PDB; 5KPX; EM; 3.90 A; O=1-115.
DR PDB; 5L3P; EM; 3.70 A; T=1-115.
DR PDB; 5LZA; EM; 3.60 A; P=2-115.
DR PDB; 5LZB; EM; 5.30 A; P=2-115.
DR PDB; 5LZC; EM; 4.80 A; P=2-115.
DR PDB; 5LZD; EM; 3.40 A; P=2-115.
DR PDB; 5LZE; EM; 3.50 A; P=2-115.
DR PDB; 5LZF; EM; 4.60 A; P=2-115.
DR PDB; 5MDV; EM; 2.97 A; P=1-115.
DR PDB; 5MDW; EM; 3.06 A; P=1-115.
DR PDB; 5MDY; EM; 3.35 A; P=1-115.
DR PDB; 5MDZ; EM; 3.10 A; P=1-115.
DR PDB; 5MGP; EM; 3.10 A; P=2-115.
DR PDB; 5NCO; EM; 4.80 A; Q=2-115.
DR PDB; 5NP6; EM; 3.60 A; n=2-115.
DR PDB; 5NWY; EM; 2.93 A; c=1-115.
DR PDB; 5O2R; EM; 3.40 A; P=2-115.
DR PDB; 5U4I; EM; 3.50 A; Q=1-115.
DR PDB; 5U9F; EM; 3.20 A; 18=1-115.
DR PDB; 5U9G; EM; 3.20 A; 18=1-115.
DR PDB; 5UYK; EM; 3.90 A; 18=2-115.
DR PDB; 5UYL; EM; 3.60 A; 18=2-115.
DR PDB; 5UYM; EM; 3.20 A; 18=2-115.
DR PDB; 5UYN; EM; 4.00 A; 18=2-115.
DR PDB; 5UYP; EM; 3.90 A; 18=2-115.
DR PDB; 5UYQ; EM; 3.80 A; 18=2-115.
DR PDB; 5WDT; EM; 3.00 A; P=2-115.
DR PDB; 5WE4; EM; 3.10 A; P=2-115.
DR PDB; 5WE6; EM; 3.40 A; P=2-115.
DR PDB; 5WFK; EM; 3.40 A; P=2-115.
DR PDB; 6BU8; EM; 3.50 A; 18=2-115.
DR PDB; 6BY1; X-ray; 3.94 A; CP/DP=2-115.
DR PDB; 6C4I; EM; 3.24 A; Q=1-115.
DR PDB; 6ENF; EM; 3.20 A; P=2-115.
DR PDB; 6ENJ; EM; 3.70 A; P=2-115.
DR PDB; 6ENU; EM; 3.10 A; P=2-115.
DR PDB; 6GBZ; EM; 3.80 A; P=2-115.
DR PDB; 6GC0; EM; 3.80 A; P=2-115.
DR PDB; 6GC4; EM; 4.30 A; P=2-115.
DR PDB; 6GC6; EM; 4.30 A; P=2-115.
DR PDB; 6GC7; EM; 4.30 A; P=2-115.
DR PDB; 6GC8; EM; 3.80 A; P=2-115.
DR PDB; 6GWT; EM; 3.80 A; P=2-115.
DR PDB; 6GXM; EM; 3.80 A; P=2-115.
DR PDB; 6GXN; EM; 3.90 A; P=2-115.
DR PDB; 6GXO; EM; 3.90 A; P=2-115.
DR PDB; 6GXP; EM; 4.40 A; P=2-115.
DR PDB; 6H4N; EM; 3.00 A; P=2-115.
DR PDB; 6H58; EM; 7.90 A; P/PP=2-115.
DR PDB; 6HRM; EM; 2.96 A; P=2-115.
DR PDB; 6I0Y; EM; 3.20 A; P=2-115.
DR PDB; 6I7V; X-ray; 2.90 A; CQ/DQ=2-115.
DR PDB; 6O9J; EM; 3.90 A; P=2-115.
DR PDB; 6O9K; EM; 4.00 A; P=2-115.
DR PDB; 6OFX; EM; 3.30 A; p=2-115.
DR PDB; 6OG7; EM; 3.30 A; p=2-115.
DR PDB; 6ORE; EM; 2.90 A; P=2-115.
DR PDB; 6ORL; EM; 3.50 A; P=2-115.
DR PDB; 6OST; EM; 4.20 A; P=2-115.
DR PDB; 6OT3; EM; 3.90 A; P=2-115.
DR PDB; 6OUO; EM; 3.70 A; P=2-115.
DR PDB; 6Q97; EM; 3.90 A; P=2-115.
DR PDB; 6Q98; EM; 4.30 A; P=1-115.
DR PDB; 6Q9A; EM; 3.70 A; P=2-114.
DR PDB; 6QDW; EM; 2.83 A; p=1-115.
DR PDB; 6QUL; EM; 3.00 A; Q=1-115.
DR PDB; 6S0K; EM; 3.10 A; Q=1-115.
DR PDB; 6SZS; EM; 3.06 A; P=1-115.
DR PDB; 6TBV; EM; 2.70 A; L191=1-115.
DR PDB; 6TC3; EM; 2.70 A; L191=1-115.
DR PDB; 6VWL; EM; 3.10 A; N=1-115.
DR PDB; 6VWM; EM; 3.40 A; N=1-115.
DR PDB; 6VWN; EM; 3.40 A; N=1-115.
DR PDB; 6WD6; EM; 3.70 A; p=2-115.
DR PDB; 6WDB; EM; 4.00 A; p=2-115.
DR PDB; 6WDC; EM; 4.20 A; p=2-115.
DR PDB; 6WDD; EM; 3.20 A; p=2-115.
DR PDB; 6WDE; EM; 3.00 A; p=2-115.
DR PDB; 6WDF; EM; 3.30 A; p=2-115.
DR PDB; 6WDG; EM; 3.30 A; p=2-115.
DR PDB; 6WDH; EM; 4.30 A; p=2-115.
DR PDB; 6WDI; EM; 4.00 A; p=2-115.
DR PDB; 6WDJ; EM; 3.70 A; p=2-115.
DR PDB; 6WDK; EM; 3.60 A; p=2-115.
DR PDB; 6WDL; EM; 3.70 A; p=2-115.
DR PDB; 6WDM; EM; 3.60 A; p=2-115.
DR PDB; 6WNT; EM; 3.10 A; p=2-115.
DR PDB; 6WNV; EM; 3.50 A; p=2-115.
DR PDB; 6WNW; EM; 3.20 A; p=2-115.
DR PDB; 6XZ7; EM; 2.10 A; P=2-115.
DR PDB; 6XZA; EM; 2.66 A; P2=2-115.
DR PDB; 6XZB; EM; 2.54 A; P2=2-115.
DR PDB; 6Y69; EM; 2.86 A; P=2-115.
DR PDB; 6YS3; EM; 2.58 A; p=1-115.
DR PDB; 6YSR; EM; 3.10 A; P=1-115.
DR PDB; 6YSS; EM; 2.60 A; P=1-115.
DR PDB; 6YST; EM; 3.20 A; P=1-115.
DR PDB; 6YSU; EM; 3.70 A; P=1-115.
DR PDB; 6ZTJ; EM; 3.40 A; BQ=1-115.
DR PDB; 6ZTL; EM; 3.50 A; BQ=1-115.
DR PDB; 6ZTM; EM; 3.30 A; BQ=1-115.
DR PDB; 6ZTN; EM; 3.90 A; BQ=1-115.
DR PDB; 6ZTO; EM; 3.00 A; BQ=1-115.
DR PDB; 6ZTP; EM; 3.00 A; BQ=1-115.
DR PDB; 6ZU1; EM; 3.00 A; BQ=1-115.
DR PDB; 7ABZ; EM; 3.21 A; P=2-115.
DR PDB; 7AC7; EM; 3.08 A; P=2-115.
DR PDB; 7ACJ; EM; 3.20 A; P=2-115.
DR PDB; 7ACR; EM; 3.44 A; P=2-115.
DR PDB; 7B5K; EM; 2.90 A; P=2-115.
DR PDB; 7BL2; EM; 3.70 A; P=1-115.
DR PDB; 7BL3; EM; 3.50 A; P=1-115.
DR PDB; 7BL4; EM; 2.40 A; P=1-115.
DR PDB; 7BL5; EM; 3.30 A; P=1-115.
DR PDB; 7BL6; EM; 4.00 A; P=1-115.
DR PDB; 7BV8; EM; 3.14 A; Q=1-115.
DR PDB; 7D6Z; EM; 3.40 A; P=1-115.
DR PDB; 7D80; EM; 4.10 A; o=1-115.
DR PDB; 7JSS; EM; 3.70 A; p=2-115.
DR PDB; 7JSW; EM; 3.80 A; p=2-115.
DR PDB; 7JSZ; EM; 3.70 A; p=2-115.
DR PDB; 7JT1; EM; 3.30 A; p=2-115.
DR PDB; 7JT2; EM; 3.50 A; p=2-115.
DR PDB; 7JT3; EM; 3.70 A; p=2-115.
DR PDB; 7K50; EM; 3.40 A; p=2-115.
DR PDB; 7K51; EM; 3.50 A; p=2-115.
DR PDB; 7K52; EM; 3.40 A; p=2-115.
DR PDB; 7K53; EM; 3.20 A; p=2-115.
DR PDB; 7K54; EM; 3.20 A; p=2-115.
DR PDB; 7K55; EM; 3.30 A; p=2-115.
DR PDB; 7LV0; EM; 3.20 A; p=2-115.
DR PDB; 7N1P; EM; 2.33 A; LS=1-115.
DR PDB; 7N2C; EM; 2.72 A; LS=1-115.
DR PDB; 7N2U; EM; 2.53 A; LS=1-115.
DR PDB; 7N2V; EM; 2.54 A; LS=1-115.
DR PDB; 7N30; EM; 2.66 A; LS=1-115.
DR PDB; 7N31; EM; 2.69 A; LS=1-115.
DR PDB; 7NBU; EM; 3.11 A; o=2-115.
DR PDB; 7NWT; EM; 2.66 A; P=1-115.
DR PDB; 7O19; EM; 2.90 A; BP=1-115.
DR PDB; 7O1A; EM; 2.40 A; BP=1-115.
DR PDB; 7O1C; EM; 2.60 A; BP=1-115.
DR PDB; 7OIZ; EM; 2.90 A; o=1-115.
DR PDB; 7OJ0; EM; 3.50 A; o=1-115.
DR PDB; 7P3K; EM; 2.90 A; o=1-115.
DR PDB; 7PJS; EM; 2.35 A; P=1-115.
DR PDB; 7PJT; EM; 6.00 A; P=1-115.
DR PDB; 7PJV; EM; 3.10 A; P=1-115.
DR PDB; 7PJW; EM; 4.00 A; P=1-115.
DR PDB; 7PJX; EM; 6.50 A; P=1-115.
DR PDB; 7PJY; EM; 3.10 A; P=1-115.
DR PDB; 7PJZ; EM; 6.00 A; P=1-115.
DR PDB; 7QG8; EM; 3.97 A; c=1-115.
DR PDB; 7QGH; EM; 4.48 A; c=1-115.
DR PDB; 7SS9; EM; 3.90 A; p=2-115.
DR PDB; 7SSD; EM; 3.30 A; p=2-115.
DR PDB; 7SSL; EM; 3.80 A; p=2-115.
DR PDB; 7SSN; EM; 3.20 A; p=2-115.
DR PDB; 7SSO; EM; 3.20 A; p=2-115.
DR PDB; 7SSW; EM; 3.80 A; p=2-115.
DR PDB; 7ST2; EM; 2.90 A; p=2-115.
DR PDB; 7ST6; EM; 3.00 A; p=2-115.
DR PDB; 7ST7; EM; 3.20 A; p=2-115.
DR PDBsum; 2J28; -.
DR PDBsum; 2RDO; -.
DR PDBsum; 3BBX; -.
DR PDBsum; 3J5L; -.
DR PDBsum; 3J7Z; -.
DR PDBsum; 3J8G; -.
DR PDBsum; 3J9Y; -.
DR PDBsum; 3J9Z; -.
DR PDBsum; 3JA1; -.
DR PDBsum; 3JBU; -.
DR PDBsum; 3JBV; -.
DR PDBsum; 3JCD; -.
DR PDBsum; 3JCE; -.
DR PDBsum; 3JCJ; -.
DR PDBsum; 3JCN; -.
DR PDBsum; 4CSU; -.
DR PDBsum; 4U1U; -.
DR PDBsum; 4U1V; -.
DR PDBsum; 4U20; -.
DR PDBsum; 4U24; -.
DR PDBsum; 4U25; -.
DR PDBsum; 4U26; -.
DR PDBsum; 4U27; -.
DR PDBsum; 4UY8; -.
DR PDBsum; 4V47; -.
DR PDBsum; 4V48; -.
DR PDBsum; 4V4H; -.
DR PDBsum; 4V4Q; -.
DR PDBsum; 4V4V; -.
DR PDBsum; 4V4W; -.
DR PDBsum; 4V50; -.
DR PDBsum; 4V52; -.
DR PDBsum; 4V53; -.
DR PDBsum; 4V54; -.
DR PDBsum; 4V55; -.
DR PDBsum; 4V56; -.
DR PDBsum; 4V57; -.
DR PDBsum; 4V5B; -.
DR PDBsum; 4V5H; -.
DR PDBsum; 4V5Y; -.
DR PDBsum; 4V64; -.
DR PDBsum; 4V65; -.
DR PDBsum; 4V66; -.
DR PDBsum; 4V69; -.
DR PDBsum; 4V6C; -.
DR PDBsum; 4V6D; -.
DR PDBsum; 4V6E; -.
DR PDBsum; 4V6K; -.
DR PDBsum; 4V6L; -.
DR PDBsum; 4V6M; -.
DR PDBsum; 4V6N; -.
DR PDBsum; 4V6O; -.
DR PDBsum; 4V6P; -.
DR PDBsum; 4V6Q; -.
DR PDBsum; 4V6R; -.
DR PDBsum; 4V6S; -.
DR PDBsum; 4V6T; -.
DR PDBsum; 4V6V; -.
DR PDBsum; 4V6Y; -.
DR PDBsum; 4V6Z; -.
DR PDBsum; 4V70; -.
DR PDBsum; 4V71; -.
DR PDBsum; 4V72; -.
DR PDBsum; 4V73; -.
DR PDBsum; 4V74; -.
DR PDBsum; 4V75; -.
DR PDBsum; 4V76; -.
DR PDBsum; 4V77; -.
DR PDBsum; 4V78; -.
DR PDBsum; 4V79; -.
DR PDBsum; 4V7A; -.
DR PDBsum; 4V7B; -.
DR PDBsum; 4V7C; -.
DR PDBsum; 4V7D; -.
DR PDBsum; 4V7I; -.
DR PDBsum; 4V7S; -.
DR PDBsum; 4V7T; -.
DR PDBsum; 4V7U; -.
DR PDBsum; 4V7V; -.
DR PDBsum; 4V85; -.
DR PDBsum; 4V89; -.
DR PDBsum; 4V9C; -.
DR PDBsum; 4V9D; -.
DR PDBsum; 4V9O; -.
DR PDBsum; 4V9P; -.
DR PDBsum; 4WF1; -.
DR PDBsum; 4WOI; -.
DR PDBsum; 4WWW; -.
DR PDBsum; 4YBB; -.
DR PDBsum; 5ADY; -.
DR PDBsum; 5AFI; -.
DR PDBsum; 5AKA; -.
DR PDBsum; 5GAD; -.
DR PDBsum; 5GAE; -.
DR PDBsum; 5GAF; -.
DR PDBsum; 5GAG; -.
DR PDBsum; 5GAH; -.
DR PDBsum; 5H5U; -.
DR PDBsum; 5IQR; -.
DR PDBsum; 5IT8; -.
DR PDBsum; 5J5B; -.
DR PDBsum; 5J7L; -.
DR PDBsum; 5J88; -.
DR PDBsum; 5J8A; -.
DR PDBsum; 5J91; -.
DR PDBsum; 5JC9; -.
DR PDBsum; 5JTE; -.
DR PDBsum; 5JU8; -.
DR PDBsum; 5KCR; -.
DR PDBsum; 5KCS; -.
DR PDBsum; 5KPS; -.
DR PDBsum; 5KPV; -.
DR PDBsum; 5KPW; -.
DR PDBsum; 5KPX; -.
DR PDBsum; 5L3P; -.
DR PDBsum; 5LZA; -.
DR PDBsum; 5LZB; -.
DR PDBsum; 5LZC; -.
DR PDBsum; 5LZD; -.
DR PDBsum; 5LZE; -.
DR PDBsum; 5LZF; -.
DR PDBsum; 5MDV; -.
DR PDBsum; 5MDW; -.
DR PDBsum; 5MDY; -.
DR PDBsum; 5MDZ; -.
DR PDBsum; 5MGP; -.
DR PDBsum; 5NCO; -.
DR PDBsum; 5NP6; -.
DR PDBsum; 5NWY; -.
DR PDBsum; 5O2R; -.
DR PDBsum; 5U4I; -.
DR PDBsum; 5U9F; -.
DR PDBsum; 5U9G; -.
DR PDBsum; 5UYK; -.
DR PDBsum; 5UYL; -.
DR PDBsum; 5UYM; -.
DR PDBsum; 5UYN; -.
DR PDBsum; 5UYP; -.
DR PDBsum; 5UYQ; -.
DR PDBsum; 5WDT; -.
DR PDBsum; 5WE4; -.
DR PDBsum; 5WE6; -.
DR PDBsum; 5WFK; -.
DR PDBsum; 6BU8; -.
DR PDBsum; 6BY1; -.
DR PDBsum; 6C4I; -.
DR PDBsum; 6ENF; -.
DR PDBsum; 6ENJ; -.
DR PDBsum; 6ENU; -.
DR PDBsum; 6GBZ; -.
DR PDBsum; 6GC0; -.
DR PDBsum; 6GC4; -.
DR PDBsum; 6GC6; -.
DR PDBsum; 6GC7; -.
DR PDBsum; 6GC8; -.
DR PDBsum; 6GWT; -.
DR PDBsum; 6GXM; -.
DR PDBsum; 6GXN; -.
DR PDBsum; 6GXO; -.
DR PDBsum; 6GXP; -.
DR PDBsum; 6H4N; -.
DR PDBsum; 6H58; -.
DR PDBsum; 6HRM; -.
DR PDBsum; 6I0Y; -.
DR PDBsum; 6I7V; -.
DR PDBsum; 6O9J; -.
DR PDBsum; 6O9K; -.
DR PDBsum; 6OFX; -.
DR PDBsum; 6OG7; -.
DR PDBsum; 6ORE; -.
DR PDBsum; 6ORL; -.
DR PDBsum; 6OST; -.
DR PDBsum; 6OT3; -.
DR PDBsum; 6OUO; -.
DR PDBsum; 6Q97; -.
DR PDBsum; 6Q98; -.
DR PDBsum; 6Q9A; -.
DR PDBsum; 6QDW; -.
DR PDBsum; 6QUL; -.
DR PDBsum; 6S0K; -.
DR PDBsum; 6SZS; -.
DR PDBsum; 6TBV; -.
DR PDBsum; 6TC3; -.
DR PDBsum; 6VWL; -.
DR PDBsum; 6VWM; -.
DR PDBsum; 6VWN; -.
DR PDBsum; 6WD6; -.
DR PDBsum; 6WDB; -.
DR PDBsum; 6WDC; -.
DR PDBsum; 6WDD; -.
DR PDBsum; 6WDE; -.
DR PDBsum; 6WDF; -.
DR PDBsum; 6WDG; -.
DR PDBsum; 6WDH; -.
DR PDBsum; 6WDI; -.
DR PDBsum; 6WDJ; -.
DR PDBsum; 6WDK; -.
DR PDBsum; 6WDL; -.
DR PDBsum; 6WDM; -.
DR PDBsum; 6WNT; -.
DR PDBsum; 6WNV; -.
DR PDBsum; 6WNW; -.
DR PDBsum; 6XZ7; -.
DR PDBsum; 6XZA; -.
DR PDBsum; 6XZB; -.
DR PDBsum; 6Y69; -.
DR PDBsum; 6YS3; -.
DR PDBsum; 6YSR; -.
DR PDBsum; 6YSS; -.
DR PDBsum; 6YST; -.
DR PDBsum; 6YSU; -.
DR PDBsum; 6ZTJ; -.
DR PDBsum; 6ZTL; -.
DR PDBsum; 6ZTM; -.
DR PDBsum; 6ZTN; -.
DR PDBsum; 6ZTO; -.
DR PDBsum; 6ZTP; -.
DR PDBsum; 6ZU1; -.
DR PDBsum; 7ABZ; -.
DR PDBsum; 7AC7; -.
DR PDBsum; 7ACJ; -.
DR PDBsum; 7ACR; -.
DR PDBsum; 7B5K; -.
DR PDBsum; 7BL2; -.
DR PDBsum; 7BL3; -.
DR PDBsum; 7BL4; -.
DR PDBsum; 7BL5; -.
DR PDBsum; 7BL6; -.
DR PDBsum; 7BV8; -.
DR PDBsum; 7D6Z; -.
DR PDBsum; 7D80; -.
DR PDBsum; 7JSS; -.
DR PDBsum; 7JSW; -.
DR PDBsum; 7JSZ; -.
DR PDBsum; 7JT1; -.
DR PDBsum; 7JT2; -.
DR PDBsum; 7JT3; -.
DR PDBsum; 7K50; -.
DR PDBsum; 7K51; -.
DR PDBsum; 7K52; -.
DR PDBsum; 7K53; -.
DR PDBsum; 7K54; -.
DR PDBsum; 7K55; -.
DR PDBsum; 7LV0; -.
DR PDBsum; 7N1P; -.
DR PDBsum; 7N2C; -.
DR PDBsum; 7N2U; -.
DR PDBsum; 7N2V; -.
DR PDBsum; 7N30; -.
DR PDBsum; 7N31; -.
DR PDBsum; 7NBU; -.
DR PDBsum; 7NWT; -.
DR PDBsum; 7O19; -.
DR PDBsum; 7O1A; -.
DR PDBsum; 7O1C; -.
DR PDBsum; 7OIZ; -.
DR PDBsum; 7OJ0; -.
DR PDBsum; 7P3K; -.
DR PDBsum; 7PJS; -.
DR PDBsum; 7PJT; -.
DR PDBsum; 7PJV; -.
DR PDBsum; 7PJW; -.
DR PDBsum; 7PJX; -.
DR PDBsum; 7PJY; -.
DR PDBsum; 7PJZ; -.
DR PDBsum; 7QG8; -.
DR PDBsum; 7QGH; -.
DR PDBsum; 7SS9; -.
DR PDBsum; 7SSD; -.
DR PDBsum; 7SSL; -.
DR PDBsum; 7SSN; -.
DR PDBsum; 7SSO; -.
DR PDBsum; 7SSW; -.
DR PDBsum; 7ST2; -.
DR PDBsum; 7ST6; -.
DR PDBsum; 7ST7; -.
DR AlphaFoldDB; P0A7K6; -.
DR SMR; P0A7K6; -.
DR ComplexPortal; CPX-3807; 50S large ribosomal subunit.
DR DIP; DIP-35793N; -.
DR IntAct; P0A7K6; 123.
DR STRING; 511145.b2606; -.
DR jPOST; P0A7K6; -.
DR PaxDb; P0A7K6; -.
DR PRIDE; P0A7K6; -.
DR EnsemblBacteria; AAC75655; AAC75655; b2606.
DR EnsemblBacteria; BAA16491; BAA16491; BAA16491.
DR GeneID; 67414076; -.
DR GeneID; 947096; -.
DR KEGG; ecj:JW2587; -.
DR KEGG; eco:b2606; -.
DR PATRIC; fig|1411691.4.peg.4133; -.
DR EchoBASE; EB0873; -.
DR eggNOG; COG0335; Bacteria.
DR HOGENOM; CLU_103507_2_1_6; -.
DR InParanoid; P0A7K6; -.
DR OMA; TITVYYE; -.
DR PhylomeDB; P0A7K6; -.
DR BioCyc; EcoCyc:EG10880-MON; -.
DR BioCyc; MetaCyc:EG10880-MON; -.
DR EvolutionaryTrace; P0A7K6; -.
DR PRO; PR:P0A7K6; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IDA:ComplexPortal.
DR GO; GO:0005829; C:cytosol; IDA:EcoCyc.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IDA:CAFA.
DR GO; GO:0070180; F:large ribosomal subunit rRNA binding; IDA:EcoCyc.
DR GO; GO:0003735; F:structural constituent of ribosome; IDA:CAFA.
DR GO; GO:0002181; P:cytoplasmic translation; IC:ComplexPortal.
DR GO; GO:0000027; P:ribosomal large subunit assembly; IDA:CAFA.
DR Gene3D; 2.30.30.790; -; 1.
DR HAMAP; MF_00402; Ribosomal_L19; 1.
DR InterPro; IPR038657; L19_sf.
DR InterPro; IPR001857; Ribosomal_L19.
DR InterPro; IPR018257; Ribosomal_L19_CS.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR15680; PTHR15680; 1.
DR Pfam; PF01245; Ribosomal_L19; 1.
DR PIRSF; PIRSF002191; Ribosomal_L19; 1.
DR PRINTS; PR00061; RIBOSOMALL19.
DR SUPFAM; SSF50104; SSF50104; 1.
DR TIGRFAMs; TIGR01024; rplS_bact; 1.
DR PROSITE; PS01015; RIBOSOMAL_L19; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:339951"
FT CHAIN 2..115
FT /note="50S ribosomal protein L19"
FT /id="PRO_0000163451"
FT HELIX 3..10
FT /evidence="ECO:0007829|PDB:6XZ7"
FT STRAND 25..33
FT /evidence="ECO:0007829|PDB:6XZ7"
FT STRAND 35..37
FT /evidence="ECO:0007829|PDB:6QUL"
FT STRAND 38..51
FT /evidence="ECO:0007829|PDB:6XZ7"
FT HELIX 54..56
FT /evidence="ECO:0007829|PDB:6XZ7"
FT STRAND 58..65
FT /evidence="ECO:0007829|PDB:6XZ7"
FT STRAND 68..75
FT /evidence="ECO:0007829|PDB:6XZ7"
FT STRAND 81..88
FT /evidence="ECO:0007829|PDB:6XZ7"
FT STRAND 93..95
FT /evidence="ECO:0007829|PDB:7BV8"
FT HELIX 98..102
FT /evidence="ECO:0007829|PDB:6XZ7"
FT HELIX 105..108
FT /evidence="ECO:0007829|PDB:6XZ7"
SQ SEQUENCE 115 AA; 13133 MW; 7BD9F2EFB9DDB06B CRC64;
MSNIIKQLEQ EQMKQDVPSF RPGDTVEVKV WVVEGSKKRL QAFEGVVIAI RNRGLHSAFT
VRKISNGEGV ERVFQTHSPV VDSISVKRRG AVRKAKLYYL RERTGKAARI KERLN
