RL19_RAT
ID RL19_RAT Reviewed; 196 AA.
AC P84100; P14118; P22908;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=60S ribosomal protein L19;
GN Name=Rpl19;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RX PubMed=3542997; DOI=10.1016/s0021-9258(19)75757-3;
RA Chan Y.-L., Lin A., McNally J., Peleg D., Meyuhas O., Wool I.G.;
RT "The primary structure of rat ribosomal protein L19. A determination from
RT the sequence of nucleotides in a cDNA and from the sequence of amino acids
RT in the protein.";
RL J. Biol. Chem. 262:1111-1115(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Fischer;
RX PubMed=7789970; DOI=10.1016/0888-7543(95)80036-l;
RA Davies B., Fried M.;
RT "The L19 ribosomal protein gene (RPL19): gene organization, chromosomal
RT mapping, and novel promoter region.";
RL Genomics 25:372-380(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary anterior lobe;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the large ribosomal subunit. The ribosome is a
CC large ribonucleoprotein complex responsible for the synthesis of
CC proteins in the cell. {ECO:0000250|UniProtKB:P84098}.
CC -!- SUBUNIT: Component of the large ribosomal subunit.
CC {ECO:0000250|UniProtKB:P84098}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P84098}.
CC -!- PTM: Citrullinated by PADI4. {ECO:0000250|UniProtKB:P84099}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL19 family.
CC {ECO:0000305}.
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DR EMBL; J02650; AAA42071.1; -; mRNA.
DR EMBL; X82202; CAA57685.1; -; Genomic_DNA.
DR EMBL; BC058135; AAH58135.1; -; mRNA.
DR PIR; A26710; R5RT19.
DR RefSeq; NP_112365.1; NM_031103.1.
DR AlphaFoldDB; P84100; -.
DR SMR; P84100; -.
DR BioGRID; 249639; 2.
DR IntAct; P84100; 4.
DR STRING; 10116.ENSRNOP00000006359; -.
DR iPTMnet; P84100; -.
DR PhosphoSitePlus; P84100; -.
DR jPOST; P84100; -.
DR PaxDb; P84100; -.
DR PRIDE; P84100; -.
DR Ensembl; ENSRNOT00000006359; ENSRNOP00000006359; ENSRNOG00000004741.
DR GeneID; 81767; -.
DR KEGG; rno:81767; -.
DR UCSC; RGD:621183; rat.
DR CTD; 6143; -.
DR RGD; 621183; Rpl19.
DR eggNOG; KOG1696; Eukaryota.
DR GeneTree; ENSGT00390000012628; -.
DR HOGENOM; CLU_083919_0_1_1; -.
DR InParanoid; P84100; -.
DR OMA; NRVWIDP; -.
DR OrthoDB; 1437042at2759; -.
DR PhylomeDB; P84100; -.
DR TreeFam; TF313598; -.
DR Reactome; R-RNO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-RNO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-RNO-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-RNO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-RNO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-RNO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:P84100; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000004741; Expressed in thymus and 19 other tissues.
DR Genevisible; P84100; RN.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IDA:RGD.
DR GO; GO:0022626; C:cytosolic ribosome; ISO:RGD.
DR GO; GO:0042788; C:polysomal ribosome; ISO:RGD.
DR GO; GO:0045202; C:synapse; ISO:RGD.
DR GO; GO:1990932; F:5.8S rRNA binding; IDA:RGD.
DR GO; GO:0070180; F:large ribosomal subunit rRNA binding; IDA:RGD.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:RGD.
DR GO; GO:0002181; P:cytoplasmic translation; ISO:RGD.
DR GO; GO:0097421; P:liver regeneration; IEP:RGD.
DR CDD; cd01417; Ribosomal_L19e_E; 1.
DR Gene3D; 1.10.1650.10; -; 1.
DR HAMAP; MF_01475; Ribosomal_L19e; 1.
DR InterPro; IPR035970; 60S_ribosomal_L19/L19e_sf.
DR InterPro; IPR000196; Ribosomal_L19/L19e.
DR InterPro; IPR023638; Ribosomal_L19/L19e_CS.
DR InterPro; IPR015972; Ribosomal_L19/L19e_dom1.
DR InterPro; IPR033935; Ribosomal_L19_euka.
DR InterPro; IPR039547; RPL19.
DR PANTHER; PTHR10722; PTHR10722; 1.
DR Pfam; PF01280; Ribosomal_L19e; 1.
DR SMART; SM01416; Ribosomal_L19e; 1.
DR SUPFAM; SSF48140; SSF48140; 1.
DR PROSITE; PS00526; RIBOSOMAL_L19E; 1.
PE 1: Evidence at protein level;
KW Citrullination; Cytoplasm; Direct protein sequencing; Isopeptide bond;
KW Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW Ubl conjugation.
FT CHAIN 1..196
FT /note="60S ribosomal protein L19"
FT /id="PRO_0000131172"
FT REGION 157..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 5
FT /note="Citrulline"
FT /evidence="ECO:0000250|UniProtKB:P84099"
FT MOD_RES 13
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P84098"
FT MOD_RES 16
FT /note="Citrulline"
FT /evidence="ECO:0000250|UniProtKB:P84099"
FT MOD_RES 38
FT /note="Citrulline"
FT /evidence="ECO:0000250|UniProtKB:P84099"
FT MOD_RES 164
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P84098"
FT MOD_RES 187
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P84098"
FT CROSSLNK 181
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO1)"
FT /evidence="ECO:0000250|UniProtKB:P84098"
SQ SEQUENCE 196 AA; 23466 MW; 4AF506393E526216 CRC64;
MSMLRLQKRL ASSVLRCGKK KVWLDPNETN EIANANSRQQ IRKLIKDGLI IRKPVTVHSR
ARCRKNTLAR RKGRHMGIGK RKGTANARMP EKVTWMRRMR ILRRLLRRYR ESKKIDRHMY
HSLYLKVKGN VFKNKRILME HIHKLKADKA RKKLLADQAE ARRSKTKEAR KRREERLQAK
KEEIIKTLSK EEETKK
