ID   RL1_STRCO               Reviewed;         241 AA.
AC   P48950; Q9L0L2;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   18-OCT-2001, sequence version 2.
DT   25-MAY-2022, entry version 122.
DE   RecName: Full=50S ribosomal protein L1 {ECO:0000255|HAMAP-Rule:MF_01318};
GN   Name=rplA {ECO:0000255|HAMAP-Rule:MF_01318}; OrderedLocusNames=SCO4649;
GN   ORFNames=SCD82.20;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-73.
RC   STRAIN=A3(2) / NRRL B-16638;
RX   PubMed=7715599; DOI=10.1007/bf00425829;
RA   Puttikhunt C., Nihira T., Yamada Y.;
RT   "Cloning, nucleotide sequence, and transcriptional analysis of the nusG
RT   gene of Streptomyces coelicolor A3(2), which encodes a putative
RT   transcriptional antiterminator.";
RL   Mol. Gen. Genet. 247:118-122(1995).
CC   -!- FUNCTION: Binds directly to 23S rRNA. The L1 stalk is quite mobile in
CC       the ribosome, and is involved in E site tRNA release.
CC       {ECO:0000255|HAMAP-Rule:MF_01318}.
CC   -!- FUNCTION: Protein L1 is also a translational repressor protein, it
CC       controls the translation of the L11 operon by binding to its mRNA.
CC       {ECO:0000255|HAMAP-Rule:MF_01318}.
CC   -!- SUBUNIT: Part of the 50S ribosomal subunit. {ECO:0000255|HAMAP-
CC       Rule:MF_01318}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL1 family.
CC       {ECO:0000255|HAMAP-Rule:MF_01318}.
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DR   EMBL; AL939120; CAB77423.1; -; Genomic_DNA.
DR   EMBL; D32254; BAA22059.1; -; Genomic_DNA.
DR   PIR; S54719; S54719.
DR   RefSeq; NP_628810.1; NC_003888.3.
DR   RefSeq; WP_003974314.1; NZ_VNID01000028.1.
DR   AlphaFoldDB; P48950; -.
DR   SMR; P48950; -.
DR   STRING; 100226.SCO4649; -.
DR   GeneID; 1100090; -.
DR   KEGG; sco:SCO4649; -.
DR   PATRIC; fig|100226.15.peg.4720; -.
DR   eggNOG; COG0081; Bacteria.
DR   HOGENOM; CLU_062853_0_0_11; -.
DR   InParanoid; P48950; -.
DR   OMA; GWTDVDV; -.
DR   PhylomeDB; P48950; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000470; P:maturation of LSU-rRNA; IBA:GO_Central.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR   CDD; cd00403; Ribosomal_L1; 1.
DR   Gene3D; 3.40.50.790; -; 1.
DR   HAMAP; MF_01318_B; Ribosomal_L1_B; 1.
DR   InterPro; IPR005878; Ribosom_L1_bac-type.
DR   InterPro; IPR002143; Ribosomal_L1.
DR   InterPro; IPR023674; Ribosomal_L1-like.
DR   InterPro; IPR028364; Ribosomal_L1/biogenesis.
DR   InterPro; IPR016095; Ribosomal_L1_3-a/b-sand.
DR   InterPro; IPR023673; Ribosomal_L1_CS.
DR   Pfam; PF00687; Ribosomal_L1; 1.
DR   PIRSF; PIRSF002155; Ribosomal_L1; 1.
DR   SUPFAM; SSF56808; SSF56808; 1.
DR   TIGRFAMs; TIGR01169; rplA_bact; 1.
DR   PROSITE; PS01199; RIBOSOMAL_L1; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Repressor; Ribonucleoprotein; Ribosomal protein;
KW   RNA-binding; rRNA-binding; Translation regulation; tRNA-binding.
FT   CHAIN           1..241
FT                   /note="50S ribosomal protein L1"
FT                   /id="PRO_0000125745"
SQ   SEQUENCE   241 AA;  25764 MW;  8DC2A82C5C7D286B CRC64;
     MSKRSKSLRA ADAKIDRDKL YAPLEAVRLA KETSTSKFDG TVEVAFRLGV DPRKADQMVR
     GTVNLPHGTG KTARVLVFAT GDRAEAATAA GADIVGSDEL IDEVSKGRLD FDAVVATPDL
     MGKVGRLGRV LGPRGLMPNP KTGTVTPDVA KAVNDIKGGK IEFRVDKHSN LHFIIGKTSF
     DDTKLVENYG AALEEILRLK PSAAKGRYIK KAALSTTMGP GIPLDSNRTR NLLVEEDPAA
     V