RL21_ECOLI
ID RL21_ECOLI Reviewed; 103 AA.
AC P0AG48; P02422; Q2M926;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=50S ribosomal protein L21 {ECO:0000255|HAMAP-Rule:MF_01363};
DE AltName: Full=Large ribosomal subunit protein bL21 {ECO:0000303|PubMed:24524803};
GN Name=rplU {ECO:0000255|HAMAP-Rule:MF_01363};
GN OrderedLocusNames=b3186, JW3153;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP PROTEIN SEQUENCE, AND SUBUNIT.
RX PubMed=387076; DOI=10.1021/bi00588a022;
RA Heiland I., Wittmann-Liebold B.;
RT "Amino acid sequence of the ribosomal protein L21 of Escherichia coli.";
RL Biochemistry 18:4605-4612(1979).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=8312607; DOI=10.3109/10425179309015624;
RA Jeong J.H., Kitakawa M.S., Isono S., Isono K.;
RT "Cloning and nucleotide sequencing of the genes, rpIU and rpmA, for
RT ribosomal proteins L21 and L27 of Escherichia coli.";
RL DNA Seq. 4:59-67(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP PROTEIN SEQUENCE OF 1-13.
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RA Pasquali C., Sanchez J.-C., Ravier F., Golaz O., Hughes G.J., Frutiger S.,
RA Paquet N., Wilkins M., Appel R.D., Bairoch A., Hochstrasser D.F.;
RL Submitted (SEP-1994) to UniProtKB.
RN [6]
RP CROSS-LINKING TO 23S RRNA.
RC STRAIN=MRE-600;
RX PubMed=6170935; DOI=10.1093/nar/9.17.4285;
RA Wower I., Wower J., Meinke M., Brimacombe R.;
RT "The use of 2-iminothiolane as an RNA-protein cross-linking agent in
RT Escherichia coli ribosomes, and the localisation on 23S RNA of sites cross-
RT linked to proteins L4, L6, L21, L23, L27 and L29.";
RL Nucleic Acids Res. 9:4285-4302(1981).
RN [7]
RP CROSS-LINKING TO L20.
RX PubMed=2665813; DOI=10.1021/bi00435a071;
RA Walleczek J., Martin T., Redl B., Stoeffler-Meilicke M., Stoeffler G.;
RT "Comparative cross-linking study on the 50S ribosomal subunit from
RT Escherichia coli.";
RL Biochemistry 28:4099-4105(1989).
RN [8]
RP IDENTIFICATION BY 2D-GEL.
RX PubMed=9298644; DOI=10.1002/elps.1150180805;
RA VanBogelen R.A., Abshire K.Z., Moldover B., Olson E.R., Neidhardt F.C.;
RT "Escherichia coli proteome analysis using the gene-protein database.";
RL Electrophoresis 18:1243-1251(1997).
RN [9]
RP MASS SPECTROMETRY, AND SUBUNIT.
RC STRAIN=K12 / ATCC 25404 / DSM 5698 / NCIMB 11290;
RX PubMed=10094780; DOI=10.1006/abio.1998.3077;
RA Arnold R.J., Reilly J.P.;
RT "Observation of Escherichia coli ribosomal proteins and their
RT posttranslational modifications by mass spectrometry.";
RL Anal. Biochem. 269:105-112(1999).
RN [10]
RP NOMENCLATURE.
RX PubMed=24524803; DOI=10.1016/j.sbi.2014.01.002;
RA Ban N., Beckmann R., Cate J.H.D., Dinman J.D., Dragon F., Ellis S.R.,
RA Lafontaine D.L.J., Lindahl L., Liljas A., Lipton J.M., McAlear M.A.,
RA Moore P.B., Noller H.F., Ortega J., Panse V.G., Ramakrishnan V.,
RA Spahn C.M.T., Steitz T.A., Tchorzewski M., Tollervey D., Warren A.J.,
RA Williamson J.R., Wilson D., Yonath A., Yusupov M.;
RT "A new system for naming ribosomal proteins.";
RL Curr. Opin. Struct. Biol. 24:165-169(2014).
RN [11]
RP X-RAY CRYSTALLOGRAPHY (3.46 ANGSTROMS) OF 2 DIFFERENT RIBOSOME STRUCTURES,
RP AND SUBUNIT.
RC STRAIN=MRE-600;
RX PubMed=16272117; DOI=10.1126/science.1117230;
RA Schuwirth B.S., Borovinskaya M.A., Hau C.W., Zhang W., Vila-Sanjurjo A.,
RA Holton J.M., Cate J.H.D.;
RT "Structures of the bacterial ribosome at 3.5 A resolution.";
RL Science 310:827-834(2005).
RN [12]
RP STRUCTURE BY ELECTRON MICROSCOPY (3.80 ANGSTROMS) OF TNAC-STALLED 50S
RP RIBOSOMAL SUBUNIT, AND SUBUNIT.
RC STRAIN=K12 / A19 / KC6;
RX PubMed=25310980; DOI=10.1016/j.celrep.2014.09.011;
RA Bischoff L., Berninghausen O., Beckmann R.;
RT "Molecular basis for the ribosome functioning as an L-tryptophan sensor.";
RL Cell Rep. 9:469-475(2014).
RN [13]
RP STRUCTURE BY ELECTRON MICROSCOPY (5.5 ANGSTROMS) OF 50S RIBOSOMAL SUBUNIT
RP IN COMPLEX WITH OBGE AND GMP-PNP, AND SUBUNIT.
RX PubMed=24844575; DOI=10.1371/journal.pbio.1001866;
RA Feng B., Mandava C.S., Guo Q., Wang J., Cao W., Li N., Zhang Y., Zhang Y.,
RA Wang Z., Wu J., Sanyal S., Lei J., Gao N.;
RT "Structural and functional insights into the mode of action of a
RT universally conserved Obg GTPase.";
RL PLoS Biol. 12:E1001866-E1001866(2014).
RN [14]
RP STRUCTURE BY ELECTRON MICROSCOPY (3.0 ANGSTROMS) OF 70S RIBOSOME IN COMPLEX
RP WITH ARFA AND RF2, AND SUBUNIT.
RX PubMed=27906160; DOI=10.1038/nature20822;
RA Ma C., Kurita D., Li N., Chen Y., Himeno H., Gao N.;
RT "Mechanistic insights into the alternative translation termination by ArfA
RT and RF2.";
RL Nature 541:550-553(2017).
RN [15]
RP STRUCTURE BY ELECTRON MICROSCOPY (3.1 ANGSTROMS) OF 70S RIBOSOME IN COMPLEX
RP WITH ARFA AND RF2, AND SUBUNIT.
RX PubMed=27906161; DOI=10.1038/nature20821;
RA Huter P., Mueller C., Beckert B., Arenz S., Berninghausen O., Beckmann R.,
RA Wilson D.N.;
RT "Structural basis for ArfA-RF2-mediated translation termination on mRNAs
RT lacking stop codons.";
RL Nature 541:546-549(2017).
RN [16]
RP STRUCTURE BY ELECTRON MICROSCOPY (2.97 ANGSTROMS) OF 70S RIBOSOME IN
RP COMPLEX WITH ARFA AND RF2, AND SUBUNIT.
RX PubMed=27934701; DOI=10.1126/science.aai9127;
RA James N.R., Brown A., Gordiyenko Y., Ramakrishnan V.;
RT "Translational termination without a stop codon.";
RL Science 354:1437-1440(2016).
RN [17]
RP STRUCTURE BY ELECTRON MICROSCOPY (3.52 ANGSTROMS) OF 70S RIBOSOME IN
RP COMPLEX WITH ARFA AND RF2, AND SUBUNIT.
RX PubMed=28077875; DOI=10.1038/nature21053;
RA Zeng F., Chen Y., Remis J., Shekhar M., Phillips J.C., Tajkhorshid E.,
RA Jin H.;
RT "Structural basis of co-translational quality control by ArfA and RF2 bound
RT to ribosome.";
RL Nature 541:554-557(2017).
CC -!- FUNCTION: This protein binds to 23S rRNA in the presence of protein
CC L20. {ECO:0000269|PubMed:2665813, ECO:0000269|PubMed:6170935}.
CC -!- SUBUNIT: Part of the 50S ribosomal subunit (PubMed:387076,
CC PubMed:10094780, PubMed:16272117, PubMed:25310980, PubMed:24844575,
CC PubMed:27934701, PubMed:27906160, PubMed:27906161). Contacts protein
CC L20 (PubMed:2665813, PubMed:6170935). {ECO:0000269|PubMed:10094780,
CC ECO:0000269|PubMed:16272117, ECO:0000269|PubMed:24844575,
CC ECO:0000269|PubMed:25310980, ECO:0000269|PubMed:2665813,
CC ECO:0000269|PubMed:27906160, ECO:0000269|PubMed:27906161,
CC ECO:0000269|PubMed:27934701, ECO:0000269|PubMed:6170935}.
CC -!- MASS SPECTROMETRY: Mass=11562.7; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:10094780};
CC -!- SIMILARITY: Belongs to the bacterial ribosomal protein bL21 family.
CC {ECO:0000255|HAMAP-Rule:MF_01363}.
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DR EMBL; D13267; BAA02525.1; -; Genomic_DNA.
DR EMBL; U18997; AAA57987.1; -; Genomic_DNA.
DR EMBL; U00096; AAC76218.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77230.1; -; Genomic_DNA.
DR PIR; JS0766; R5EC21.
DR RefSeq; NP_417653.1; NC_000913.3.
DR RefSeq; WP_000271401.1; NZ_STEB01000012.1.
DR PDB; 2J28; EM; 8.00 A; R=1-103.
DR PDB; 2RDO; EM; 9.10 A; R=1-103.
DR PDB; 3BBX; EM; 10.00 A; R=1-103.
DR PDB; 3IY9; EM; 14.10 A; R=1-103.
DR PDB; 3J5L; EM; 6.60 A; R=1-103.
DR PDB; 3J7Z; EM; 3.90 A; R=1-103.
DR PDB; 3J8G; EM; 5.00 A; R=1-103.
DR PDB; 3J9Y; EM; 3.90 A; R=1-103.
DR PDB; 3J9Z; EM; 3.60 A; LP=1-103.
DR PDB; 3JA1; EM; 3.60 A; LT=1-103.
DR PDB; 3JBU; EM; 3.64 A; r=1-103.
DR PDB; 3JBV; EM; 3.32 A; r=1-103.
DR PDB; 3JCD; EM; 3.70 A; R=1-103.
DR PDB; 3JCE; EM; 3.20 A; R=1-103.
DR PDB; 3JCJ; EM; 3.70 A; Q=1-103.
DR PDB; 3JCN; EM; 4.60 A; R=1-103.
DR PDB; 4CSU; EM; 5.50 A; R=1-103.
DR PDB; 4U1U; X-ray; 2.95 A; BR/DR=1-103.
DR PDB; 4U1V; X-ray; 3.00 A; BR/DR=1-103.
DR PDB; 4U20; X-ray; 2.90 A; BR/DR=1-103.
DR PDB; 4U24; X-ray; 2.90 A; BR/DR=1-103.
DR PDB; 4U25; X-ray; 2.90 A; BR/DR=1-103.
DR PDB; 4U26; X-ray; 2.80 A; BR/DR=1-103.
DR PDB; 4U27; X-ray; 2.80 A; BR/DR=1-103.
DR PDB; 4UY8; EM; 3.80 A; R=1-103.
DR PDB; 4V4H; X-ray; 3.46 A; BR/DR=1-103.
DR PDB; 4V4Q; X-ray; 3.46 A; BR/DR=1-103.
DR PDB; 4V50; X-ray; 3.22 A; BR/DR=1-103.
DR PDB; 4V52; X-ray; 3.21 A; BR/DR=1-103.
DR PDB; 4V53; X-ray; 3.54 A; BR/DR=1-103.
DR PDB; 4V54; X-ray; 3.30 A; BR/DR=1-103.
DR PDB; 4V55; X-ray; 4.00 A; BR/DR=1-103.
DR PDB; 4V56; X-ray; 3.93 A; BR/DR=1-103.
DR PDB; 4V57; X-ray; 3.50 A; BR/DR=1-103.
DR PDB; 4V5B; X-ray; 3.74 A; AR/CR=1-103.
DR PDB; 4V5H; EM; 5.80 A; BR=1-103.
DR PDB; 4V5Y; X-ray; 4.45 A; BR/DR=1-103.
DR PDB; 4V64; X-ray; 3.50 A; BR/DR=1-103.
DR PDB; 4V65; EM; 9.00 A; BK=1-103.
DR PDB; 4V66; EM; 9.00 A; BK=1-103.
DR PDB; 4V69; EM; 6.70 A; BR=1-103.
DR PDB; 4V6C; X-ray; 3.19 A; BR/DR=1-103.
DR PDB; 4V6D; X-ray; 3.81 A; BR/DR=1-103.
DR PDB; 4V6E; X-ray; 3.71 A; BR/DR=1-103.
DR PDB; 4V6K; EM; 8.25 A; AS=1-103.
DR PDB; 4V6L; EM; 13.20 A; BS=1-103.
DR PDB; 4V6M; EM; 7.10 A; BR=1-103.
DR PDB; 4V6N; EM; 12.10 A; AT=1-103.
DR PDB; 4V6O; EM; 14.70 A; BT=1-103.
DR PDB; 4V6P; EM; 13.50 A; BT=1-103.
DR PDB; 4V6Q; EM; 11.50 A; BT=1-103.
DR PDB; 4V6R; EM; 11.50 A; BT=1-103.
DR PDB; 4V6S; EM; 13.10 A; AT=1-103.
DR PDB; 4V6T; EM; 8.30 A; BR=1-103.
DR PDB; 4V6V; EM; 9.80 A; BV=1-103.
DR PDB; 4V6Y; EM; 12.00 A; BR=1-103.
DR PDB; 4V6Z; EM; 12.00 A; BR=1-103.
DR PDB; 4V70; EM; 17.00 A; BR=1-103.
DR PDB; 4V71; EM; 20.00 A; BR=1-103.
DR PDB; 4V72; EM; 13.00 A; BR=1-103.
DR PDB; 4V73; EM; 15.00 A; BR=1-103.
DR PDB; 4V74; EM; 17.00 A; BR=1-103.
DR PDB; 4V75; EM; 12.00 A; BR=1-103.
DR PDB; 4V76; EM; 17.00 A; BR=1-103.
DR PDB; 4V77; EM; 17.00 A; BR=1-103.
DR PDB; 4V78; EM; 20.00 A; BR=1-103.
DR PDB; 4V79; EM; 15.00 A; BR=1-103.
DR PDB; 4V7A; EM; 9.00 A; BR=1-103.
DR PDB; 4V7B; EM; 6.80 A; BR=1-103.
DR PDB; 4V7C; EM; 7.60 A; BT=1-103.
DR PDB; 4V7D; EM; 7.60 A; AU=1-103.
DR PDB; 4V7I; EM; 9.60 A; AR=1-103.
DR PDB; 4V7S; X-ray; 3.25 A; BR/DR=1-103.
DR PDB; 4V7T; X-ray; 3.19 A; BR/DR=1-103.
DR PDB; 4V7U; X-ray; 3.10 A; BR/DR=1-103.
DR PDB; 4V7V; X-ray; 3.29 A; BR/DR=1-103.
DR PDB; 4V85; X-ray; 3.20 A; BV=1-103.
DR PDB; 4V89; X-ray; 3.70 A; BV=1-103.
DR PDB; 4V9C; X-ray; 3.30 A; BR/DR=1-103.
DR PDB; 4V9D; X-ray; 3.00 A; CR/DR=1-103.
DR PDB; 4V9O; X-ray; 2.90 A; AR/CR/ER/GR=1-103.
DR PDB; 4V9P; X-ray; 2.90 A; AR/CR/ER/GR=1-103.
DR PDB; 4WF1; X-ray; 3.09 A; BR/DR=1-103.
DR PDB; 4WOI; X-ray; 3.00 A; BR/CR=1-103.
DR PDB; 4WWW; X-ray; 3.10 A; RR/YR=1-103.
DR PDB; 4YBB; X-ray; 2.10 A; CS/DS=1-103.
DR PDB; 5ADY; EM; 4.50 A; R=1-103.
DR PDB; 5AFI; EM; 2.90 A; R=1-103.
DR PDB; 5AKA; EM; 5.70 A; R=1-103.
DR PDB; 5GAD; EM; 3.70 A; S=1-103.
DR PDB; 5GAE; EM; 3.33 A; S=1-103.
DR PDB; 5GAF; EM; 4.30 A; S=1-103.
DR PDB; 5GAG; EM; 3.80 A; S=1-103.
DR PDB; 5GAH; EM; 3.80 A; S=1-103.
DR PDB; 5H5U; EM; 3.00 A; S=1-103.
DR PDB; 5IQR; EM; 3.00 A; R=1-103.
DR PDB; 5IT8; X-ray; 3.12 A; CS/DS=1-103.
DR PDB; 5J5B; X-ray; 2.80 A; CS/DS=1-103.
DR PDB; 5J7L; X-ray; 3.00 A; CS/DS=1-103.
DR PDB; 5J88; X-ray; 3.32 A; CS/DS=1-103.
DR PDB; 5J8A; X-ray; 3.10 A; CS/DS=1-103.
DR PDB; 5J91; X-ray; 2.96 A; CS/DS=1-103.
DR PDB; 5JC9; X-ray; 3.03 A; CS/DS=1-103.
DR PDB; 5JTE; EM; 3.60 A; BR=1-103.
DR PDB; 5JU8; EM; 3.60 A; BR=1-103.
DR PDB; 5KCR; EM; 3.60 A; 1V=1-103.
DR PDB; 5KCS; EM; 3.90 A; 1V=1-103.
DR PDB; 5KPS; EM; 3.90 A; R=1-103.
DR PDB; 5KPV; EM; 4.10 A; Q=1-103.
DR PDB; 5KPW; EM; 3.90 A; Q=1-103.
DR PDB; 5KPX; EM; 3.90 A; Q=1-103.
DR PDB; 5L3P; EM; 3.70 A; V=1-103.
DR PDB; 5LZA; EM; 3.60 A; R=1-103.
DR PDB; 5LZB; EM; 5.30 A; R=1-103.
DR PDB; 5LZC; EM; 4.80 A; R=1-103.
DR PDB; 5LZD; EM; 3.40 A; R=1-103.
DR PDB; 5LZE; EM; 3.50 A; R=1-103.
DR PDB; 5LZF; EM; 4.60 A; R=1-103.
DR PDB; 5MDV; EM; 2.97 A; R=1-103.
DR PDB; 5MDW; EM; 3.06 A; R=1-103.
DR PDB; 5MDY; EM; 3.35 A; R=1-103.
DR PDB; 5MDZ; EM; 3.10 A; R=1-103.
DR PDB; 5MGP; EM; 3.10 A; R=1-103.
DR PDB; 5NCO; EM; 4.80 A; S=1-103.
DR PDB; 5NP6; EM; 3.60 A; p=1-103.
DR PDB; 5NWY; EM; 2.93 A; e=1-103.
DR PDB; 5O2R; EM; 3.40 A; R=1-103.
DR PDB; 5U4I; EM; 3.50 A; S=1-103.
DR PDB; 5U9F; EM; 3.20 A; 20=1-103.
DR PDB; 5U9G; EM; 3.20 A; 20=1-103.
DR PDB; 5UYK; EM; 3.90 A; 20=1-103.
DR PDB; 5UYL; EM; 3.60 A; 20=1-103.
DR PDB; 5UYM; EM; 3.20 A; 20=1-103.
DR PDB; 5UYN; EM; 4.00 A; 20=1-103.
DR PDB; 5UYP; EM; 3.90 A; 20=1-103.
DR PDB; 5UYQ; EM; 3.80 A; 20=1-103.
DR PDB; 5WDT; EM; 3.00 A; R=1-102.
DR PDB; 5WE4; EM; 3.10 A; R=1-102.
DR PDB; 5WE6; EM; 3.40 A; R=1-102.
DR PDB; 5WFK; EM; 3.40 A; R=1-102.
DR PDB; 6BU8; EM; 3.50 A; 20=1-103.
DR PDB; 6BY1; X-ray; 3.94 A; CR/DR=1-103.
DR PDB; 6C4I; EM; 3.24 A; S=1-103.
DR PDB; 6ENF; EM; 3.20 A; R=1-103.
DR PDB; 6ENJ; EM; 3.70 A; R=1-103.
DR PDB; 6ENU; EM; 3.10 A; R=1-103.
DR PDB; 6GBZ; EM; 3.80 A; R=1-103.
DR PDB; 6GC0; EM; 3.80 A; R=1-103.
DR PDB; 6GC4; EM; 4.30 A; R=1-103.
DR PDB; 6GC6; EM; 4.30 A; R=1-103.
DR PDB; 6GC7; EM; 4.30 A; R=1-103.
DR PDB; 6GC8; EM; 3.80 A; R=1-103.
DR PDB; 6GWT; EM; 3.80 A; R=1-103.
DR PDB; 6GXM; EM; 3.80 A; R=1-103.
DR PDB; 6GXN; EM; 3.90 A; R=1-103.
DR PDB; 6GXO; EM; 3.90 A; R=1-103.
DR PDB; 6GXP; EM; 4.40 A; R=1-103.
DR PDB; 6H4N; EM; 3.00 A; R=1-103.
DR PDB; 6H58; EM; 7.90 A; R/RR=1-103.
DR PDB; 6HRM; EM; 2.96 A; R=1-103.
DR PDB; 6I0Y; EM; 3.20 A; R=1-103.
DR PDB; 6I7V; X-ray; 2.90 A; CS/DS=1-103.
DR PDB; 6O9J; EM; 3.90 A; R=1-103.
DR PDB; 6O9K; EM; 4.00 A; R=1-103.
DR PDB; 6OFX; EM; 3.30 A; r=1-103.
DR PDB; 6OG7; EM; 3.30 A; r=1-103.
DR PDB; 6ORE; EM; 2.90 A; R=1-103.
DR PDB; 6ORL; EM; 3.50 A; R=1-103.
DR PDB; 6OST; EM; 4.20 A; R=1-103.
DR PDB; 6OT3; EM; 3.90 A; R=1-103.
DR PDB; 6OUO; EM; 3.70 A; R=1-103.
DR PDB; 6Q97; EM; 3.90 A; R=1-103.
DR PDB; 6Q98; EM; 4.30 A; R=1-103.
DR PDB; 6Q9A; EM; 3.70 A; R=1-102.
DR PDB; 6QDW; EM; 2.83 A; r=1-103.
DR PDB; 6QUL; EM; 3.00 A; S=1-103.
DR PDB; 6S0K; EM; 3.10 A; S=1-103.
DR PDB; 6SZS; EM; 3.06 A; R=1-103.
DR PDB; 6TBV; EM; 2.70 A; L211=1-103.
DR PDB; 6TC3; EM; 2.70 A; L211=1-103.
DR PDB; 6VWL; EM; 3.10 A; P=1-103.
DR PDB; 6VWM; EM; 3.40 A; P=1-103.
DR PDB; 6VWN; EM; 3.40 A; P=1-103.
DR PDB; 6WD6; EM; 3.70 A; r=1-103.
DR PDB; 6WDB; EM; 4.00 A; r=1-103.
DR PDB; 6WDC; EM; 4.20 A; r=1-103.
DR PDB; 6WDD; EM; 3.20 A; r=1-103.
DR PDB; 6WDE; EM; 3.00 A; r=1-103.
DR PDB; 6WDF; EM; 3.30 A; r=1-103.
DR PDB; 6WDG; EM; 3.30 A; r=1-103.
DR PDB; 6WDH; EM; 4.30 A; r=1-103.
DR PDB; 6WDI; EM; 4.00 A; r=1-103.
DR PDB; 6WDJ; EM; 3.70 A; r=1-103.
DR PDB; 6WDK; EM; 3.60 A; r=1-103.
DR PDB; 6WDL; EM; 3.70 A; r=1-103.
DR PDB; 6WDM; EM; 3.60 A; r=1-103.
DR PDB; 6WNT; EM; 3.10 A; r=1-103.
DR PDB; 6WNV; EM; 3.50 A; r=1-103.
DR PDB; 6WNW; EM; 3.20 A; r=1-103.
DR PDB; 6XZ7; EM; 2.10 A; R=1-103.
DR PDB; 6XZA; EM; 2.66 A; R2=1-103.
DR PDB; 6XZB; EM; 2.54 A; R2=1-103.
DR PDB; 6Y69; EM; 2.86 A; R=1-103.
DR PDB; 6YS3; EM; 2.58 A; r=1-103.
DR PDB; 6YSR; EM; 3.10 A; R=1-103.
DR PDB; 6YSS; EM; 2.60 A; R=1-103.
DR PDB; 6YST; EM; 3.20 A; R=1-103.
DR PDB; 6YSU; EM; 3.70 A; R=1-103.
DR PDB; 6ZTJ; EM; 3.40 A; BS=1-103.
DR PDB; 6ZTL; EM; 3.50 A; BS=1-103.
DR PDB; 6ZTM; EM; 3.30 A; BS=1-103.
DR PDB; 6ZTN; EM; 3.90 A; BS=1-103.
DR PDB; 6ZTO; EM; 3.00 A; BS=1-103.
DR PDB; 6ZTP; EM; 3.00 A; BS=1-103.
DR PDB; 6ZU1; EM; 3.00 A; BS=1-103.
DR PDB; 7ABZ; EM; 3.21 A; R=1-103.
DR PDB; 7AC7; EM; 3.08 A; R=1-103.
DR PDB; 7ACJ; EM; 3.20 A; R=1-103.
DR PDB; 7ACR; EM; 3.44 A; R=1-103.
DR PDB; 7B5K; EM; 2.90 A; R=1-103.
DR PDB; 7BL2; EM; 3.70 A; R=1-103.
DR PDB; 7BL3; EM; 3.50 A; R=1-103.
DR PDB; 7BL4; EM; 2.40 A; R=1-103.
DR PDB; 7BL5; EM; 3.30 A; R=1-103.
DR PDB; 7BL6; EM; 4.00 A; R=1-103.
DR PDB; 7BV8; EM; 3.14 A; S=1-103.
DR PDB; 7D6Z; EM; 3.40 A; R=1-103.
DR PDB; 7D80; EM; 4.10 A; q=1-103.
DR PDB; 7JSS; EM; 3.70 A; r=1-103.
DR PDB; 7JSW; EM; 3.80 A; r=1-103.
DR PDB; 7JSZ; EM; 3.70 A; r=1-103.
DR PDB; 7JT1; EM; 3.30 A; r=1-103.
DR PDB; 7JT2; EM; 3.50 A; r=1-103.
DR PDB; 7JT3; EM; 3.70 A; r=1-103.
DR PDB; 7K50; EM; 3.40 A; r=1-103.
DR PDB; 7K51; EM; 3.50 A; r=1-103.
DR PDB; 7K52; EM; 3.40 A; r=1-103.
DR PDB; 7K53; EM; 3.20 A; r=1-103.
DR PDB; 7K54; EM; 3.20 A; r=1-103.
DR PDB; 7K55; EM; 3.30 A; r=1-103.
DR PDB; 7LV0; EM; 3.20 A; r=1-103.
DR PDB; 7N1P; EM; 2.33 A; LU=1-103.
DR PDB; 7N2C; EM; 2.72 A; LU=1-103.
DR PDB; 7N2U; EM; 2.53 A; LU=1-103.
DR PDB; 7N2V; EM; 2.54 A; LU=1-103.
DR PDB; 7N30; EM; 2.66 A; LU=1-103.
DR PDB; 7N31; EM; 2.69 A; LU=1-103.
DR PDB; 7NBU; EM; 3.11 A; q=1-103.
DR PDB; 7NSO; EM; 2.90 A; R=1-103.
DR PDB; 7NSP; EM; 3.50 A; R=1-103.
DR PDB; 7NSQ; EM; 3.10 A; R=1-103.
DR PDB; 7NWT; EM; 2.66 A; R=1-103.
DR PDB; 7NWW; EM; 3.05 A; Q=1-103.
DR PDB; 7O19; EM; 2.90 A; BR=1-103.
DR PDB; 7O1A; EM; 2.40 A; BR=1-103.
DR PDB; 7O1C; EM; 2.60 A; BR=1-103.
DR PDB; 7OIF; EM; 3.00 A; Q=1-103.
DR PDB; 7OIG; EM; 3.20 A; Q=1-103.
DR PDB; 7OII; EM; 3.00 A; Q=1-103.
DR PDB; 7OIZ; EM; 2.90 A; q=1-103.
DR PDB; 7OJ0; EM; 3.50 A; q=1-103.
DR PDB; 7OT5; EM; 2.90 A; Q=1-103.
DR PDB; 7P3K; EM; 2.90 A; q=1-103.
DR PDB; 7PJS; EM; 2.35 A; R=1-103.
DR PDB; 7PJT; EM; 6.00 A; R=1-103.
DR PDB; 7PJV; EM; 3.10 A; R=1-103.
DR PDB; 7PJW; EM; 4.00 A; R=1-103.
DR PDB; 7PJX; EM; 6.50 A; R=1-103.
DR PDB; 7PJY; EM; 3.10 A; R=1-103.
DR PDB; 7PJZ; EM; 6.00 A; R=1-103.
DR PDB; 7QG8; EM; 3.97 A; e=1-103.
DR PDB; 7QGH; EM; 4.48 A; e=1-103.
DR PDB; 7SS9; EM; 3.90 A; r=1-103.
DR PDB; 7SSD; EM; 3.30 A; r=1-103.
DR PDB; 7SSL; EM; 3.80 A; r=1-103.
DR PDB; 7SSN; EM; 3.20 A; r=1-103.
DR PDB; 7SSO; EM; 3.20 A; r=1-103.
DR PDB; 7SSW; EM; 3.80 A; r=1-103.
DR PDB; 7ST2; EM; 2.90 A; r=1-103.
DR PDB; 7ST6; EM; 3.00 A; r=1-103.
DR PDB; 7ST7; EM; 3.20 A; r=1-103.
DR PDBsum; 2J28; -.
DR PDBsum; 2RDO; -.
DR PDBsum; 3BBX; -.
DR PDBsum; 3IY9; -.
DR PDBsum; 3J5L; -.
DR PDBsum; 3J7Z; -.
DR PDBsum; 3J8G; -.
DR PDBsum; 3J9Y; -.
DR PDBsum; 3J9Z; -.
DR PDBsum; 3JA1; -.
DR PDBsum; 3JBU; -.
DR PDBsum; 3JBV; -.
DR PDBsum; 3JCD; -.
DR PDBsum; 3JCE; -.
DR PDBsum; 3JCJ; -.
DR PDBsum; 3JCN; -.
DR PDBsum; 4CSU; -.
DR PDBsum; 4U1U; -.
DR PDBsum; 4U1V; -.
DR PDBsum; 4U20; -.
DR PDBsum; 4U24; -.
DR PDBsum; 4U25; -.
DR PDBsum; 4U26; -.
DR PDBsum; 4U27; -.
DR PDBsum; 4UY8; -.
DR PDBsum; 4V4H; -.
DR PDBsum; 4V4Q; -.
DR PDBsum; 4V50; -.
DR PDBsum; 4V52; -.
DR PDBsum; 4V53; -.
DR PDBsum; 4V54; -.
DR PDBsum; 4V55; -.
DR PDBsum; 4V56; -.
DR PDBsum; 4V57; -.
DR PDBsum; 4V5B; -.
DR PDBsum; 4V5H; -.
DR PDBsum; 4V5Y; -.
DR PDBsum; 4V64; -.
DR PDBsum; 4V65; -.
DR PDBsum; 4V66; -.
DR PDBsum; 4V69; -.
DR PDBsum; 4V6C; -.
DR PDBsum; 4V6D; -.
DR PDBsum; 4V6E; -.
DR PDBsum; 4V6K; -.
DR PDBsum; 4V6L; -.
DR PDBsum; 4V6M; -.
DR PDBsum; 4V6N; -.
DR PDBsum; 4V6O; -.
DR PDBsum; 4V6P; -.
DR PDBsum; 4V6Q; -.
DR PDBsum; 4V6R; -.
DR PDBsum; 4V6S; -.
DR PDBsum; 4V6T; -.
DR PDBsum; 4V6V; -.
DR PDBsum; 4V6Y; -.
DR PDBsum; 4V6Z; -.
DR PDBsum; 4V70; -.
DR PDBsum; 4V71; -.
DR PDBsum; 4V72; -.
DR PDBsum; 4V73; -.
DR PDBsum; 4V74; -.
DR PDBsum; 4V75; -.
DR PDBsum; 4V76; -.
DR PDBsum; 4V77; -.
DR PDBsum; 4V78; -.
DR PDBsum; 4V79; -.
DR PDBsum; 4V7A; -.
DR PDBsum; 4V7B; -.
DR PDBsum; 4V7C; -.
DR PDBsum; 4V7D; -.
DR PDBsum; 4V7I; -.
DR PDBsum; 4V7S; -.
DR PDBsum; 4V7T; -.
DR PDBsum; 4V7U; -.
DR PDBsum; 4V7V; -.
DR PDBsum; 4V85; -.
DR PDBsum; 4V89; -.
DR PDBsum; 4V9C; -.
DR PDBsum; 4V9D; -.
DR PDBsum; 4V9O; -.
DR PDBsum; 4V9P; -.
DR PDBsum; 4WF1; -.
DR PDBsum; 4WOI; -.
DR PDBsum; 4WWW; -.
DR PDBsum; 4YBB; -.
DR PDBsum; 5ADY; -.
DR PDBsum; 5AFI; -.
DR PDBsum; 5AKA; -.
DR PDBsum; 5GAD; -.
DR PDBsum; 5GAE; -.
DR PDBsum; 5GAF; -.
DR PDBsum; 5GAG; -.
DR PDBsum; 5GAH; -.
DR PDBsum; 5H5U; -.
DR PDBsum; 5IQR; -.
DR PDBsum; 5IT8; -.
DR PDBsum; 5J5B; -.
DR PDBsum; 5J7L; -.
DR PDBsum; 5J88; -.
DR PDBsum; 5J8A; -.
DR PDBsum; 5J91; -.
DR PDBsum; 5JC9; -.
DR PDBsum; 5JTE; -.
DR PDBsum; 5JU8; -.
DR PDBsum; 5KCR; -.
DR PDBsum; 5KCS; -.
DR PDBsum; 5KPS; -.
DR PDBsum; 5KPV; -.
DR PDBsum; 5KPW; -.
DR PDBsum; 5KPX; -.
DR PDBsum; 5L3P; -.
DR PDBsum; 5LZA; -.
DR PDBsum; 5LZB; -.
DR PDBsum; 5LZC; -.
DR PDBsum; 5LZD; -.
DR PDBsum; 5LZE; -.
DR PDBsum; 5LZF; -.
DR PDBsum; 5MDV; -.
DR PDBsum; 5MDW; -.
DR PDBsum; 5MDY; -.
DR PDBsum; 5MDZ; -.
DR PDBsum; 5MGP; -.
DR PDBsum; 5NCO; -.
DR PDBsum; 5NP6; -.
DR PDBsum; 5NWY; -.
DR PDBsum; 5O2R; -.
DR PDBsum; 5U4I; -.
DR PDBsum; 5U9F; -.
DR PDBsum; 5U9G; -.
DR PDBsum; 5UYK; -.
DR PDBsum; 5UYL; -.
DR PDBsum; 5UYM; -.
DR PDBsum; 5UYN; -.
DR PDBsum; 5UYP; -.
DR PDBsum; 5UYQ; -.
DR PDBsum; 5WDT; -.
DR PDBsum; 5WE4; -.
DR PDBsum; 5WE6; -.
DR PDBsum; 5WFK; -.
DR PDBsum; 6BU8; -.
DR PDBsum; 6BY1; -.
DR PDBsum; 6C4I; -.
DR PDBsum; 6ENF; -.
DR PDBsum; 6ENJ; -.
DR PDBsum; 6ENU; -.
DR PDBsum; 6GBZ; -.
DR PDBsum; 6GC0; -.
DR PDBsum; 6GC4; -.
DR PDBsum; 6GC6; -.
DR PDBsum; 6GC7; -.
DR PDBsum; 6GC8; -.
DR PDBsum; 6GWT; -.
DR PDBsum; 6GXM; -.
DR PDBsum; 6GXN; -.
DR PDBsum; 6GXO; -.
DR PDBsum; 6GXP; -.
DR PDBsum; 6H4N; -.
DR PDBsum; 6H58; -.
DR PDBsum; 6HRM; -.
DR PDBsum; 6I0Y; -.
DR PDBsum; 6I7V; -.
DR PDBsum; 6O9J; -.
DR PDBsum; 6O9K; -.
DR PDBsum; 6OFX; -.
DR PDBsum; 6OG7; -.
DR PDBsum; 6ORE; -.
DR PDBsum; 6ORL; -.
DR PDBsum; 6OST; -.
DR PDBsum; 6OT3; -.
DR PDBsum; 6OUO; -.
DR PDBsum; 6Q97; -.
DR PDBsum; 6Q98; -.
DR PDBsum; 6Q9A; -.
DR PDBsum; 6QDW; -.
DR PDBsum; 6QUL; -.
DR PDBsum; 6S0K; -.
DR PDBsum; 6SZS; -.
DR PDBsum; 6TBV; -.
DR PDBsum; 6TC3; -.
DR PDBsum; 6VWL; -.
DR PDBsum; 6VWM; -.
DR PDBsum; 6VWN; -.
DR PDBsum; 6WD6; -.
DR PDBsum; 6WDB; -.
DR PDBsum; 6WDC; -.
DR PDBsum; 6WDD; -.
DR PDBsum; 6WDE; -.
DR PDBsum; 6WDF; -.
DR PDBsum; 6WDG; -.
DR PDBsum; 6WDH; -.
DR PDBsum; 6WDI; -.
DR PDBsum; 6WDJ; -.
DR PDBsum; 6WDK; -.
DR PDBsum; 6WDL; -.
DR PDBsum; 6WDM; -.
DR PDBsum; 6WNT; -.
DR PDBsum; 6WNV; -.
DR PDBsum; 6WNW; -.
DR PDBsum; 6XZ7; -.
DR PDBsum; 6XZA; -.
DR PDBsum; 6XZB; -.
DR PDBsum; 6Y69; -.
DR PDBsum; 6YS3; -.
DR PDBsum; 6YSR; -.
DR PDBsum; 6YSS; -.
DR PDBsum; 6YST; -.
DR PDBsum; 6YSU; -.
DR PDBsum; 6ZTJ; -.
DR PDBsum; 6ZTL; -.
DR PDBsum; 6ZTM; -.
DR PDBsum; 6ZTN; -.
DR PDBsum; 6ZTO; -.
DR PDBsum; 6ZTP; -.
DR PDBsum; 6ZU1; -.
DR PDBsum; 7ABZ; -.
DR PDBsum; 7AC7; -.
DR PDBsum; 7ACJ; -.
DR PDBsum; 7ACR; -.
DR PDBsum; 7B5K; -.
DR PDBsum; 7BL2; -.
DR PDBsum; 7BL3; -.
DR PDBsum; 7BL4; -.
DR PDBsum; 7BL5; -.
DR PDBsum; 7BL6; -.
DR PDBsum; 7BV8; -.
DR PDBsum; 7D6Z; -.
DR PDBsum; 7D80; -.
DR PDBsum; 7JSS; -.
DR PDBsum; 7JSW; -.
DR PDBsum; 7JSZ; -.
DR PDBsum; 7JT1; -.
DR PDBsum; 7JT2; -.
DR PDBsum; 7JT3; -.
DR PDBsum; 7K50; -.
DR PDBsum; 7K51; -.
DR PDBsum; 7K52; -.
DR PDBsum; 7K53; -.
DR PDBsum; 7K54; -.
DR PDBsum; 7K55; -.
DR PDBsum; 7LV0; -.
DR PDBsum; 7N1P; -.
DR PDBsum; 7N2C; -.
DR PDBsum; 7N2U; -.
DR PDBsum; 7N2V; -.
DR PDBsum; 7N30; -.
DR PDBsum; 7N31; -.
DR PDBsum; 7NBU; -.
DR PDBsum; 7NSO; -.
DR PDBsum; 7NSP; -.
DR PDBsum; 7NSQ; -.
DR PDBsum; 7NWT; -.
DR PDBsum; 7NWW; -.
DR PDBsum; 7O19; -.
DR PDBsum; 7O1A; -.
DR PDBsum; 7O1C; -.
DR PDBsum; 7OIF; -.
DR PDBsum; 7OIG; -.
DR PDBsum; 7OII; -.
DR PDBsum; 7OIZ; -.
DR PDBsum; 7OJ0; -.
DR PDBsum; 7OT5; -.
DR PDBsum; 7P3K; -.
DR PDBsum; 7PJS; -.
DR PDBsum; 7PJT; -.
DR PDBsum; 7PJV; -.
DR PDBsum; 7PJW; -.
DR PDBsum; 7PJX; -.
DR PDBsum; 7PJY; -.
DR PDBsum; 7PJZ; -.
DR PDBsum; 7QG8; -.
DR PDBsum; 7QGH; -.
DR PDBsum; 7SS9; -.
DR PDBsum; 7SSD; -.
DR PDBsum; 7SSL; -.
DR PDBsum; 7SSN; -.
DR PDBsum; 7SSO; -.
DR PDBsum; 7SSW; -.
DR PDBsum; 7ST2; -.
DR PDBsum; 7ST6; -.
DR PDBsum; 7ST7; -.
DR AlphaFoldDB; P0AG48; -.
DR SMR; P0AG48; -.
DR BioGRID; 4261074; 217.
DR BioGRID; 853300; 1.
DR ComplexPortal; CPX-3807; 50S large ribosomal subunit.
DR DIP; DIP-47852N; -.
DR IntAct; P0AG48; 103.
DR STRING; 511145.b3186; -.
DR SWISS-2DPAGE; P0AG48; -.
DR jPOST; P0AG48; -.
DR PaxDb; P0AG48; -.
DR PRIDE; P0AG48; -.
DR EnsemblBacteria; AAC76218; AAC76218; b3186.
DR EnsemblBacteria; BAE77230; BAE77230; BAE77230.
DR GeneID; 67415980; -.
DR GeneID; 949057; -.
DR KEGG; ecj:JW3153; -.
DR KEGG; eco:b3186; -.
DR PATRIC; fig|1411691.4.peg.3545; -.
DR EchoBASE; EB4295; -.
DR eggNOG; COG0261; Bacteria.
DR HOGENOM; CLU_061463_3_3_6; -.
DR InParanoid; P0AG48; -.
DR OMA; HRQEITR; -.
DR PhylomeDB; P0AG48; -.
DR BioCyc; EcoCyc:EG50001-MON; -.
DR BioCyc; MetaCyc:EG50001-MON; -.
DR EvolutionaryTrace; P0AG48; -.
DR PRO; PR:P0AG48; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IDA:ComplexPortal.
DR GO; GO:0005829; C:cytosol; IDA:EcoCyc.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IDA:EcoCyc.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0002181; P:cytoplasmic translation; IC:ComplexPortal.
DR HAMAP; MF_01363; Ribosomal_L21; 1.
DR InterPro; IPR036164; L21-like_sf.
DR InterPro; IPR028909; L21p-like.
DR InterPro; IPR001787; Ribosomal_L21.
DR InterPro; IPR018258; Ribosomal_L21_CS.
DR PANTHER; PTHR21349; PTHR21349; 1.
DR Pfam; PF00829; Ribosomal_L21p; 1.
DR SUPFAM; SSF141091; SSF141091; 1.
DR TIGRFAMs; TIGR00061; L21; 1.
DR PROSITE; PS01169; RIBOSOMAL_L21; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding.
FT CHAIN 1..103
FT /note="50S ribosomal protein L21"
FT /id="PRO_0000181000"
FT STRAND 2..7
FT /evidence="ECO:0007829|PDB:6XZ7"
FT STRAND 10..15
FT /evidence="ECO:0007829|PDB:6XZ7"
FT STRAND 19..23
FT /evidence="ECO:0007829|PDB:6XZ7"
FT STRAND 32..35
FT /evidence="ECO:0007829|PDB:6XZ7"
FT STRAND 38..43
FT /evidence="ECO:0007829|PDB:6XZ7"
FT STRAND 46..49
FT /evidence="ECO:0007829|PDB:6XZ7"
FT STRAND 51..53
FT /evidence="ECO:0007829|PDB:6XZ7"
FT STRAND 58..68
FT /evidence="ECO:0007829|PDB:6XZ7"
FT STRAND 72..78
FT /evidence="ECO:0007829|PDB:6XZ7"
FT TURN 79..82
FT /evidence="ECO:0007829|PDB:6XZ7"
FT STRAND 83..89
FT /evidence="ECO:0007829|PDB:6XZ7"
FT STRAND 92..102
FT /evidence="ECO:0007829|PDB:6XZ7"
SQ SEQUENCE 103 AA; 11564 MW; 9221F104EC9C8CDB CRC64;
MYAVFQSGGK QHRVSEGQTV RLEKLDIATG ETVEFAEVLM IANGEEVKIG VPFVDGGVIK
AEVVAHGRGE KVKIVKFRRR KHYRKQQGHR QWFTDVKITG ISA
