RL21_MOUSE
ID RL21_MOUSE Reviewed; 160 AA.
AC O09167;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=60S ribosomal protein L21;
GN Name=Rpl21;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RA Rocha D., Anderson E., Botcherby M., Jordan B.;
RL Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Component of the large ribosomal subunit. The ribosome is a
CC large ribonucleoprotein complex responsible for the synthesis of
CC proteins in the cell. {ECO:0000250|UniProtKB:P46778}.
CC -!- SUBUNIT: Component of the large ribosomal subunit.
CC {ECO:0000250|UniProtKB:P46778}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:P46778}. Cytoplasm
CC {ECO:0000250|UniProtKB:P46778}. Endoplasmic reticulum
CC {ECO:0000250|UniProtKB:P49666}. Note=Detected on cytosolic polysomes
CC (By similarity). Detected in ribosomes that are associated with the
CC rough endoplasmic reticulum (By similarity).
CC {ECO:0000250|UniProtKB:P46778, ECO:0000250|UniProtKB:P49666}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL21 family.
CC {ECO:0000305}.
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DR EMBL; U93863; AAB52255.1; -; mRNA.
DR PDB; 6SWA; EM; 3.10 A; R=1-160.
DR PDB; 7LS1; EM; 3.30 A; N2=1-160.
DR PDB; 7LS2; EM; 3.10 A; N2=1-160.
DR PDBsum; 6SWA; -.
DR PDBsum; 7LS1; -.
DR PDBsum; 7LS2; -.
DR AlphaFoldDB; O09167; -.
DR SMR; O09167; -.
DR ComplexPortal; CPX-5262; 60S cytosolic large ribosomal subunit.
DR CORUM; O09167; -.
DR IntAct; O09167; 4.
DR MINT; O09167; -.
DR STRING; 10090.ENSMUSP00000041652; -.
DR iPTMnet; O09167; -.
DR PhosphoSitePlus; O09167; -.
DR SwissPalm; O09167; -.
DR EPD; O09167; -.
DR jPOST; O09167; -.
DR MaxQB; O09167; -.
DR PaxDb; O09167; -.
DR PeptideAtlas; O09167; -.
DR PRIDE; O09167; -.
DR ProteomicsDB; 255157; -.
DR MGI; MGI:1278340; Rpl21.
DR eggNOG; KOG1732; Eukaryota.
DR InParanoid; O09167; -.
DR PhylomeDB; O09167; -.
DR Reactome; R-MMU-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-MMU-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-MMU-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-MMU-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-MMU-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-MMU-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR ChiTaRS; Rpl21; mouse.
DR PRO; PR:O09167; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; O09167; protein.
DR GO; GO:0005737; C:cytoplasm; IC:ComplexPortal.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IPI:ComplexPortal.
DR GO; GO:0022626; C:cytosolic ribosome; ISO:MGI.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005840; C:ribosome; ISO:MGI.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:MGI.
DR GO; GO:0002181; P:cytoplasmic translation; IC:ComplexPortal.
DR Gene3D; 2.30.30.70; -; 1.
DR InterPro; IPR036948; Ribosomal_L21_sf.
DR InterPro; IPR001147; Ribosomal_L21e.
DR InterPro; IPR018259; Ribosomal_L21e_CS.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR20981; PTHR20981; 1.
DR Pfam; PF01157; Ribosomal_L21e; 1.
DR SUPFAM; SSF50104; SSF50104; 1.
DR PROSITE; PS01171; RIBOSOMAL_L21E; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Endoplasmic reticulum; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..160
FT /note="60S ribosomal protein L21"
FT /id="PRO_0000149670"
FT REGION 111..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 160 AA; 18562 MW; 74F215B19EA63CAB CRC64;
MTNTKGKRRG TRYMFSRPFR KHGVVPLATY MRIYKKGDIV DIKGMGTVQK GMPHKCYHGK
TGRVYNVTQH AVGIIVNKQV KGKILAKRIN VRIEHIKHSK SRDSFLKRVK ENDQKKKEAK
EKGTWVQLKR HAAPPREAHF VRTNGKEPEL LEPIPYEFMA
