RL21_PIG
ID RL21_PIG Reviewed; 160 AA.
AC P49666; F1RTJ9;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 28-FEB-2018, sequence version 3.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=60S ribosomal protein L21;
GN Name=RPL21;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1] {ECO:0000312|EMBL:AMR57225.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Sun W.-S., Lee J.-W.;
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000312|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000312|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-62.
RC TISSUE=Small intestine;
RX PubMed=8672129; DOI=10.1007/s003359900153;
RA Winteroe A.K., Fredholm M., Davies W.;
RT "Evaluation and characterization of a porcine small intestine cDNA library:
RT analysis of 839 clones.";
RL Mamm. Genome 7:509-517(1996).
RN [4] {ECO:0007744|PDB:3J7O, ECO:0007744|PDB:3J7P, ECO:0007744|PDB:3J7Q}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS), FUNCTION, SUBCELLULAR
RP LOCATION, AND SUBUNIT.
RX PubMed=24930395; DOI=10.1016/j.cell.2014.05.024;
RA Voorhees R.M., Fernandez I.S., Scheres S.H., Hegde R.S.;
RT "Structure of the mammalian ribosome-Sec61 complex to 3.4 A resolution.";
RL Cell 157:1632-1643(2014).
CC -!- FUNCTION: Component of the large ribosomal subunit (PubMed:24930395).
CC The ribosome is a large ribonucleoprotein complex responsible for the
CC synthesis of proteins in the cell (PubMed:24930395).
CC {ECO:0000269|PubMed:24930395}.
CC -!- SUBUNIT: Component of the large ribosomal subunit.
CC {ECO:0000269|PubMed:24930395}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:P46778}. Cytoplasm
CC {ECO:0000250|UniProtKB:P46778}. Endoplasmic reticulum
CC {ECO:0000269|PubMed:24930395}. Note=Detected on cytosolic polysomes (By
CC similarity). Detected in ribosomes that are associated with the rough
CC endoplasmic reticulum (PubMed:24930395). {ECO:0000250|UniProtKB:P46778,
CC ECO:0000269|PubMed:24930395}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL21 family.
CC {ECO:0000305}.
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DR EMBL; AEMK02000075; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KU891824; AMR57225.1; -; mRNA.
DR EMBL; F14727; CAA23212.1; -; mRNA.
DR RefSeq; XP_003482912.1; XM_003482864.3.
DR RefSeq; XP_003482913.1; XM_003482865.3.
DR PDB; 3J7O; EM; 3.50 A; T=1-160.
DR PDB; 3J7P; EM; 3.50 A; T=1-160.
DR PDB; 3J7Q; EM; 3.50 A; T=1-160.
DR PDB; 3J7R; EM; 3.90 A; T=1-160.
DR PDBsum; 3J7O; -.
DR PDBsum; 3J7P; -.
DR PDBsum; 3J7Q; -.
DR PDBsum; 3J7R; -.
DR AlphaFoldDB; P49666; -.
DR SMR; P49666; -.
DR STRING; 9823.ENSSSCP00000009925; -.
DR PaxDb; P49666; -.
DR PeptideAtlas; P49666; -.
DR PRIDE; P49666; -.
DR Ensembl; ENSSSCT00000045322; ENSSSCP00000058298; ENSSSCG00000009303.
DR Ensembl; ENSSSCT00025068392; ENSSSCP00025029416; ENSSSCG00025050118.
DR Ensembl; ENSSSCT00030024726; ENSSSCP00030011043; ENSSSCG00030017902.
DR Ensembl; ENSSSCT00035092027; ENSSSCP00035038591; ENSSSCG00035068194.
DR Ensembl; ENSSSCT00040017272; ENSSSCP00040007029; ENSSSCG00040013019.
DR Ensembl; ENSSSCT00050004765; ENSSSCP00050001927; ENSSSCG00050003555.
DR Ensembl; ENSSSCT00055046935; ENSSSCP00055037438; ENSSSCG00055023820.
DR Ensembl; ENSSSCT00060039953; ENSSSCP00060016939; ENSSSCG00060029569.
DR Ensembl; ENSSSCT00065085728; ENSSSCP00065037474; ENSSSCG00065062470.
DR Ensembl; ENSSSCT00070020149; ENSSSCP00070016752; ENSSSCG00070010348.
DR Ensembl; ENSSSCT00070046981; ENSSSCP00070039631; ENSSSCG00070023559.
DR GeneID; 100736809; -.
DR KEGG; ssc:100736809; -.
DR CTD; 6144; -.
DR eggNOG; KOG1732; Eukaryota.
DR GeneTree; ENSGT00950000182922; -.
DR InParanoid; P49666; -.
DR OMA; IIYNVTP; -.
DR OrthoDB; 1455026at2759; -.
DR TreeFam; TF314640; -.
DR Proteomes; UP000008227; Chromosome 11.
DR Proteomes; UP000314985; Chromosome 11.
DR Bgee; ENSSSCG00000009303; Expressed in semimembranosus muscle and 44 other tissues.
DR ExpressionAtlas; P49666; baseline and differential.
DR Genevisible; F1RTJ9; SS.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0031090; C:organelle membrane; IEA:UniProt.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR Gene3D; 2.30.30.70; -; 1.
DR InterPro; IPR036948; Ribosomal_L21_sf.
DR InterPro; IPR001147; Ribosomal_L21e.
DR InterPro; IPR018259; Ribosomal_L21e_CS.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR20981; PTHR20981; 1.
DR Pfam; PF01157; Ribosomal_L21e; 1.
DR SUPFAM; SSF50104; SSF50104; 1.
DR PROSITE; PS01171; RIBOSOMAL_L21E; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Endoplasmic reticulum; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..160
FT /note="60S ribosomal protein L21"
FT /id="PRO_0000149671"
FT REGION 112..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 52
FT /note="M -> L (in Ref. 3; CAA23212)"
SQ SEQUENCE 160 AA; 18565 MW; C51D0B5E8EB9D69E CRC64;
MTNTKGKRRG TRYMFSRPFR KHGVVPLATY MRIYKKGDIV DIKGMGTVQK GMPHKCYHGK
TGRVYNVTQH AVGIVVNKQV KGKILAKRIN VRIEHIKHSK SRDSFLKRVK ENDQKKKEAK
EKGTWVQLKR QPAPPREAHF VRTNGKEPEL LEPIPYEFMA
