RL22L_HUMAN
ID RL22L_HUMAN Reviewed; 122 AA.
AC Q6P5R6; Q32Q77;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=60S ribosomal protein L22-like 1;
DE AltName: Full=Large ribosomal subunit protein eL22-like 1;
GN Name=RPL22L1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-118 AND SER-120, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19369195; DOI=10.1074/mcp.m800588-mcp200;
RA Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,
RA Mann M., Daub H.;
RT "Large-scale proteomics analysis of the human kinome.";
RL Mol. Cell. Proteomics 8:1751-1764(2009).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-118, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-112 AND SER-118, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-118, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- INTERACTION:
CC Q6P5R6; Q9H190: SDCBP2; NbExp=3; IntAct=EBI-2512545, EBI-742426;
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL22 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH62731.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BC062731; AAH62731.1; ALT_INIT; mRNA.
DR EMBL; BC107708; AAI07709.1; -; mRNA.
DR CCDS; CCDS46955.1; -.
DR RefSeq; NP_001093115.1; NM_001099645.1.
DR AlphaFoldDB; Q6P5R6; -.
DR SMR; Q6P5R6; -.
DR BioGRID; 128356; 54.
DR IntAct; Q6P5R6; 20.
DR STRING; 9606.ENSP00000346080; -.
DR iPTMnet; Q6P5R6; -.
DR PhosphoSitePlus; Q6P5R6; -.
DR BioMuta; RPL22L1; -.
DR DMDM; 109893176; -.
DR EPD; Q6P5R6; -.
DR jPOST; Q6P5R6; -.
DR MassIVE; Q6P5R6; -.
DR MaxQB; Q6P5R6; -.
DR PaxDb; Q6P5R6; -.
DR PeptideAtlas; Q6P5R6; -.
DR PRIDE; Q6P5R6; -.
DR ProteomicsDB; 67002; -.
DR Antibodypedia; 71210; 57 antibodies from 16 providers.
DR DNASU; 200916; -.
DR Ensembl; ENST00000295830.13; ENSP00000346080.7; ENSG00000163584.18.
DR GeneID; 200916; -.
DR KEGG; hsa:200916; -.
DR MANE-Select; ENST00000295830.13; ENSP00000346080.7; NM_001099645.2; NP_001093115.1.
DR UCSC; uc003fhc.5; human.
DR CTD; 200916; -.
DR DisGeNET; 200916; -.
DR GeneCards; RPL22L1; -.
DR HGNC; HGNC:27610; RPL22L1.
DR HPA; ENSG00000163584; Low tissue specificity.
DR neXtProt; NX_Q6P5R6; -.
DR OpenTargets; ENSG00000163584; -.
DR PharmGKB; PA142671026; -.
DR VEuPathDB; HostDB:ENSG00000163584; -.
DR eggNOG; KOG3434; Eukaryota.
DR GeneTree; ENSGT00940000154509; -.
DR InParanoid; Q6P5R6; -.
DR OMA; KMAPQKD; -.
DR OrthoDB; 1594080at2759; -.
DR PhylomeDB; Q6P5R6; -.
DR TreeFam; TF313018; -.
DR PathwayCommons; Q6P5R6; -.
DR Reactome; R-HSA-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-HSA-156902; Peptide chain elongation.
DR Reactome; R-HSA-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-HSA-192823; Viral mRNA Translation.
DR Reactome; R-HSA-2408557; Selenocysteine synthesis.
DR Reactome; R-HSA-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-HSA-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-HSA-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-HSA-72764; Eukaryotic Translation Termination.
DR Reactome; R-HSA-9010553; Regulation of expression of SLITs and ROBOs.
DR Reactome; R-HSA-9633012; Response of EIF2AK4 (GCN2) to amino acid deficiency.
DR Reactome; R-HSA-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-HSA-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR SignaLink; Q6P5R6; -.
DR SIGNOR; Q6P5R6; -.
DR BioGRID-ORCS; 200916; 93 hits in 1072 CRISPR screens.
DR ChiTaRS; RPL22L1; human.
DR GenomeRNAi; 200916; -.
DR Pharos; Q6P5R6; Tdark.
DR PRO; PR:Q6P5R6; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q6P5R6; protein.
DR Bgee; ENSG00000163584; Expressed in cartilage tissue and 180 other tissues.
DR ExpressionAtlas; Q6P5R6; baseline and differential.
DR Genevisible; Q6P5R6; HS.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR Gene3D; 3.30.1360.210; -; 1.
DR InterPro; IPR002671; Ribosomal_L22e.
DR InterPro; IPR038526; Ribosomal_L22e_sf.
DR InterPro; IPR028370; RPL22L1.
DR PANTHER; PTHR10064; PTHR10064; 1.
DR PANTHER; PTHR10064:SF1; PTHR10064:SF1; 1.
DR Pfam; PF01776; Ribosomal_L22e; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..122
FT /note="60S ribosomal protein L22-like 1"
FT /id="PRO_0000240632"
FT MOD_RES 112
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT MOD_RES 118
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:21406692"
FT MOD_RES 120
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT VARIANT 97
FT /note="V -> F (in dbSNP:rs13462)"
FT /id="VAR_061771"
SQ SEQUENCE 122 AA; 14607 MW; 6C480CDD9FFAE761 CRC64;
MAPQKDRKPK RSTWRFNLDL THPVEDGIFD SGNFEQFLRE KVKVNGKTGN LGNVVHIERF
KNKITVVSEK QFSKRYLKYL TKKYLKKNNL RDWLRVVASD KETYELRYFQ ISQDEDESES
ED
