ID   RL22_CAEEL              Reviewed;         130 AA.
AC   P52819; P85027;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=60S ribosomal protein L22;
GN   Name=rpl-22; ORFNames=C27A2.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   PROTEIN SEQUENCE OF 2-8; 29-37; 38-48; 55-64 AND 110-115 (ISOFORM A), AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RA   Bienvenut W.V.;
RL   Submitted (AUG-2006) to UniProtKB.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=a;
CC         IsoId=P52819-1; Sequence=Displayed;
CC       Name=b;
CC         IsoId=P52819-2; Sequence=VSP_021365, VSP_021366;
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL22 family.
CC       {ECO:0000305}.
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DR   EMBL; FO080349; CCD63067.1; -; Genomic_DNA.
DR   EMBL; FO080349; CCD63068.1; -; Genomic_DNA.
DR   PIR; T15648; T15648.
DR   RefSeq; NP_494932.1; NM_062531.5. [P52819-1]
DR   AlphaFoldDB; P52819; -.
DR   SMR; P52819; -.
DR   BioGRID; 39224; 86.
DR   IntAct; P52819; 1.
DR   STRING; 6239.C27A2.2a; -.
DR   iPTMnet; P52819; -.
DR   EPD; P52819; -.
DR   PaxDb; P52819; -.
DR   PeptideAtlas; P52819; -.
DR   EnsemblMetazoa; C27A2.2a.1; C27A2.2a.1; WBGene00004434. [P52819-1]
DR   GeneID; 173873; -.
DR   KEGG; cel:CELE_C27A2.2; -.
DR   UCSC; C27A2.2a.1; c. elegans. [P52819-1]
DR   CTD; 173873; -.
DR   WormBase; C27A2.2a; CE04102; WBGene00004434; rpl-22. [P52819-1]
DR   eggNOG; KOG3434; Eukaryota.
DR   GeneTree; ENSGT00940000169435; -.
DR   HOGENOM; CLU_105624_0_1_1; -.
DR   InParanoid; P52819; -.
DR   OMA; SELCYFQ; -.
DR   OrthoDB; 1594080at2759; -.
DR   PhylomeDB; P52819; -.
DR   Reactome; R-CEL-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-CEL-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-CEL-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   Reactome; R-CEL-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-CEL-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   Reactome; R-CEL-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-CEL-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   PRO; PR:P52819; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00004434; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR   Gene3D; 3.30.1360.210; -; 1.
DR   InterPro; IPR002671; Ribosomal_L22e.
DR   InterPro; IPR038526; Ribosomal_L22e_sf.
DR   PANTHER; PTHR10064; PTHR10064; 1.
DR   Pfam; PF01776; Ribosomal_L22e; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Direct protein sequencing; Reference proteome;
KW   Ribonucleoprotein; Ribosomal protein.
FT   INIT_MET        1
FT                   /note="Removed"
FT   CHAIN           2..130
FT                   /note="60S ribosomal protein L22"
FT                   /id="PRO_0000215508"
FT   VAR_SEQ         42..53
FT                   /note="EAFLNEKIKVNG -> SIEFPSLSQDQA (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_021365"
FT   VAR_SEQ         54..130
FT                   /note="Missing (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_021366"
SQ   SEQUENCE   130 AA;  14946 MW;  9E2244161D88759F CRC64;
     MVPKPHAKSA KKALRKKKVH LKFNVECKNP VEDGILRIED LEAFLNEKIK VNGKTGHLAA
     NNVKVEVAKS KVSVVSEVPF SKRYLKYLTK KYLKRNSLRD WLRVVAVNKN TYEVRYFHIN
     DGEDAGSDHE