ID   RL22_ENTFA              Reviewed;         115 AA.
AC   Q839F9;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=50S ribosomal protein L22 {ECO:0000255|HAMAP-Rule:MF_01331};
GN   Name=rplV {ECO:0000255|HAMAP-Rule:MF_01331}; OrderedLocusNames=EF_0211;
OS   Enterococcus faecalis (strain ATCC 700802 / V583).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=226185;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700802 / V583;
RX   PubMed=12663927; DOI=10.1126/science.1080613;
RA   Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R.,
RA   Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H.,
RA   Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C.,
RA   DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R., Nelson W.C.,
RA   Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M.,
RA   Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.;
RT   "Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus
RT   faecalis.";
RL   Science 299:2071-2074(2003).
CC   -!- FUNCTION: This protein binds specifically to 23S rRNA; its binding is
CC       stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is
CC       important during the early stages of 50S assembly. It makes multiple
CC       contacts with different domains of the 23S rRNA in the assembled 50S
CC       subunit and ribosome (By similarity). {ECO:0000255|HAMAP-
CC       Rule:MF_01331}.
CC   -!- FUNCTION: The globular domain of the protein is located near the
CC       polypeptide exit tunnel on the outside of the subunit, while an
CC       extended beta-hairpin is found that lines the wall of the exit tunnel
CC       in the center of the 70S ribosome. {ECO:0000255|HAMAP-Rule:MF_01331}.
CC   -!- SUBUNIT: Part of the 50S ribosomal subunit. {ECO:0000255|HAMAP-
CC       Rule:MF_01331}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL22 family.
CC       {ECO:0000255|HAMAP-Rule:MF_01331}.
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DR   EMBL; AE016830; AAO80080.1; -; Genomic_DNA.
DR   RefSeq; NP_814009.1; NC_004668.1.
DR   RefSeq; WP_002356206.1; NZ_KE136524.1.
DR   PDB; 6WU9; EM; 2.90 A; T=4-115.
DR   PDB; 7P7R; EM; 2.90 A; V=1-115.
DR   PDBsum; 6WU9; -.
DR   PDBsum; 7P7R; -.
DR   AlphaFoldDB; Q839F9; -.
DR   SMR; Q839F9; -.
DR   STRING; 226185.EF_0211; -.
DR   PRIDE; Q839F9; -.
DR   EnsemblBacteria; AAO80080; AAO80080; EF_0211.
DR   GeneID; 60892706; -.
DR   KEGG; efa:EF0211; -.
DR   PATRIC; fig|226185.45.peg.55; -.
DR   eggNOG; COG0091; Bacteria.
DR   HOGENOM; CLU_083987_3_3_9; -.
DR   OMA; KRIQPRA; -.
DR   Proteomes; UP000001415; Chromosome.
DR   GO; GO:0015934; C:large ribosomal subunit; IEA:InterPro.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR   CDD; cd00336; Ribosomal_L22; 1.
DR   Gene3D; 3.90.470.10; -; 1.
DR   HAMAP; MF_01331_B; Ribosomal_L22_B; 1.
DR   InterPro; IPR001063; Ribosomal_L22.
DR   InterPro; IPR018260; Ribosomal_L22/L17_CS.
DR   InterPro; IPR036394; Ribosomal_L22/L17_sf.
DR   InterPro; IPR005727; Ribosomal_L22_bac/chlpt-type.
DR   PANTHER; PTHR13501; PTHR13501; 1.
DR   Pfam; PF00237; Ribosomal_L22; 1.
DR   SUPFAM; SSF54843; SSF54843; 1.
DR   TIGRFAMs; TIGR01044; rplV_bact; 1.
DR   PROSITE; PS00464; RIBOSOMAL_L22; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW   RNA-binding; rRNA-binding.
FT   CHAIN           1..115
FT                   /note="50S ribosomal protein L22"
FT                   /id="PRO_0000125156"
FT   STRAND          7..17
FT                   /evidence="ECO:0007829|PDB:6WU9"
FT   HELIX           19..26
FT                   /evidence="ECO:0007829|PDB:6WU9"
FT   TURN            27..31
FT                   /evidence="ECO:0007829|PDB:6WU9"
FT   HELIX           34..42
FT                   /evidence="ECO:0007829|PDB:6WU9"
FT   HELIX           49..65
FT                   /evidence="ECO:0007829|PDB:6WU9"
FT   TURN            71..73
FT                   /evidence="ECO:0007829|PDB:6WU9"
FT   STRAND          75..83
FT                   /evidence="ECO:0007829|PDB:6WU9"
FT   STRAND          87..92
FT                   /evidence="ECO:0007829|PDB:6WU9"
FT   HELIX           94..96
FT                   /evidence="ECO:0007829|PDB:6WU9"
FT   STRAND          98..103
FT                   /evidence="ECO:0007829|PDB:6WU9"
FT   STRAND          106..113
FT                   /evidence="ECO:0007829|PDB:6WU9"
SQ   SEQUENCE   115 AA;  12453 MW;  F966E47B03BD3195 CRC64;
     MSEQITSAKA TAKTVRTSPR KARLVIDLIR GKSVADAISI LKFTPNKSAG IIEKVLMSAV
     ANAENNFDLD VESLVVSEAF VNEGPTMKRF RPRAKGSASP INKRTSHITV VVTEK