RL22_HAEIN
ID RL22_HAEIN Reviewed; 110 AA.
AC P44360;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=50S ribosomal protein L22;
GN Name=rplV; Synonyms=rpl22; OrderedLocusNames=HI_0782;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
RN [2]
RP MACROLIDE RESISTANT VARIANTS.
RC STRAIN=S1, S2, S26, S3, S49, S58, and S60;
RX PubMed=12604536; DOI=10.1128/aac.47.3.1017-1022.2003;
RA Peric M., Bozdogan B., Jacobs M.R., Appelbaum P.C.;
RT "Effects of an efflux mechanism and ribosomal mutations on macrolide
RT susceptibility of Haemophilus influenzae clinical isolates.";
RL Antimicrob. Agents Chemother. 47:1017-1022(2003).
CC -!- FUNCTION: This protein binds specifically to 23S rRNA; its binding is
CC stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is
CC important during the early stages of 50S assembly. It makes multiple
CC contacts with different domains of the 23S rRNA in the assembled 50S
CC subunit and ribosome (By similarity). {ECO:0000250}.
CC -!- FUNCTION: The globular domain of the protein is located near the
CC polypeptide exit tunnel on the outside of the subunit, while an
CC extended beta-hairpin is found that lines the wall of the exit tunnel
CC in the center of the 70S ribosome. {ECO:0000250}.
CC -!- SUBUNIT: Part of the 50S ribosomal subunit. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL22 family.
CC {ECO:0000305}.
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DR EMBL; L42023; AAC22441.1; -; Genomic_DNA.
DR PIR; A64093; A64093.
DR RefSeq; NP_438941.1; NC_000907.1.
DR RefSeq; WP_005625897.1; NC_000907.1.
DR AlphaFoldDB; P44360; -.
DR SMR; P44360; -.
DR STRING; 71421.HI_0782; -.
DR EnsemblBacteria; AAC22441; AAC22441; HI_0782.
DR GeneID; 56956914; -.
DR KEGG; hin:HI_0782; -.
DR PATRIC; fig|71421.8.peg.821; -.
DR eggNOG; COG0091; Bacteria.
DR HOGENOM; CLU_083987_3_3_6; -.
DR OMA; KRIQPRA; -.
DR PhylomeDB; P44360; -.
DR BioCyc; HINF71421:G1GJ1-822-MON; -.
DR PRO; PR:P44360; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0015934; C:large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR GO; GO:0042255; P:ribosome assembly; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR CDD; cd00336; Ribosomal_L22; 1.
DR Gene3D; 3.90.470.10; -; 1.
DR HAMAP; MF_01331_B; Ribosomal_L22_B; 1.
DR InterPro; IPR001063; Ribosomal_L22.
DR InterPro; IPR018260; Ribosomal_L22/L17_CS.
DR InterPro; IPR036394; Ribosomal_L22/L17_sf.
DR InterPro; IPR005727; Ribosomal_L22_bac/chlpt-type.
DR PANTHER; PTHR13501; PTHR13501; 1.
DR Pfam; PF00237; Ribosomal_L22; 1.
DR SUPFAM; SSF54843; SSF54843; 1.
DR TIGRFAMs; TIGR01044; rplV_bact; 1.
DR PROSITE; PS00464; RIBOSOMAL_L22; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein; RNA-binding; rRNA-binding.
FT CHAIN 1..110
FT /note="50S ribosomal protein L22"
FT /id="PRO_0000125161"
FT VARIANT 77
FT /note="D -> DDEGPSM (in strain: S1; confers macrolide
FT resistance)"
FT VARIANT 81
FT /note="Missing (in strain: S42; confers macrolide
FT resistance)"
FT VARIANT 82
FT /note="Missing (in strain: S53; confers macrolide
FT resistance)"
FT VARIANT 88
FT /note="R -> RRAKG (in strain: S26; confers macrolide
FT resistance)"
FT VARIANT 91
FT /note="G -> D (in strain: S2 and S3; confers macrolide
FT resistance)"
FT VARIANT 91
FT /note="G -> GKG (in strain: S49; confers macrolide
FT resistance)"
FT VARIANT 91
FT /note="G -> GRADR (in strain: S60; confers macrolide
FT resistance)"
FT VARIANT 91
FT /note="G -> GRAG (in strain: S58; confers macrolide
FT resistance)"
FT VARIANT 95..96
FT /note="Missing (in strain: S40; confers macrolide
FT resistance)"
FT VARIANT 96..98
FT /note="Missing (in strain: S23; confers macrolide
FT resistance)"
SQ SEQUENCE 110 AA; 12148 MW; 196E517BDC27AC62 CRC64;
METIAKHRYA RTSAQKARLV ADLIRGKKVA QALEILTFTN KKAAALVKKV LESAIANAEH
NDGADIDDLK VAKIFVDEGP SMKRVMPRAK GRADRILKRT SHITVVVSDR
