ID   RL22_METH1              Reviewed;         129 AA.
AC   Q8GM55; D1J881;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   02-MAR-2010, sequence version 2.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=50S ribosomal protein L22 {ECO:0000255|HAMAP-Rule:MF_01331};
GN   Name=rplV {ECO:0000255|HAMAP-Rule:MF_01331}; OrderedLocusNames=MHO_2930;
OS   Metamycoplasma hominis (strain ATCC 23114 / DSM 25592 / NBRC 14850 / NCTC
OS   10111 / PG21) (Mycoplasma hominis).
OC   Bacteria; Tenericutes; Mycoplasmoidales; Metamycoplasmataceae;
OC   Metamycoplasma.
OX   NCBI_TaxID=347256;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12234836; DOI=10.1128/aac.46.10.3142-3150.2002;
RA   Pereyre S., Gonzalez P., De Barbeyrac B., Darnige A., Renaudin H.,
RA   Charron A., Raherison S., Bebear C., Bebear C.M.;
RT   "Mutations in 23S rRNA account for intrinsic resistance to macrolides in
RT   Mycoplasma hominis and Mycoplasma fermentans and for acquired resistance to
RT   macrolides in M. hominis.";
RL   Antimicrob. Agents Chemother. 46:3142-3150(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23114 / DSM 25592 / NBRC 14850 / NCTC 10111 / PG21;
RX   PubMed=19816563; DOI=10.1371/journal.pgen.1000677;
RA   Pereyre S., Sirand-Pugnet P., Beven L., Charron A., Renaudin H., Barre A.,
RA   Avenaud P., Jacob D., Couloux A., Barbe V., de Daruvar A., Blanchard A.,
RA   Bebear C.;
RT   "Life on arginine for Mycoplasma hominis: clues from its minimal genome and
RT   comparison with other human urogenital mycoplasmas.";
RL   PLoS Genet. 5:E1000677-E1000677(2009).
CC   -!- FUNCTION: This protein binds specifically to 23S rRNA; its binding is
CC       stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is
CC       important during the early stages of 50S assembly. It makes multiple
CC       contacts with different domains of the 23S rRNA in the assembled 50S
CC       subunit and ribosome (By similarity). {ECO:0000255|HAMAP-
CC       Rule:MF_01331}.
CC   -!- FUNCTION: The globular domain of the protein is located near the
CC       polypeptide exit tunnel on the outside of the subunit, while an
CC       extended beta-hairpin is found that lines the wall of the exit tunnel
CC       in the center of the 70S ribosome. {ECO:0000255|HAMAP-Rule:MF_01331}.
CC   -!- SUBUNIT: Part of the 50S ribosomal subunit. {ECO:0000255|HAMAP-
CC       Rule:MF_01331}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL22 family.
CC       {ECO:0000255|HAMAP-Rule:MF_01331}.
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DR   EMBL; AY083306; AAM08940.1; -; Genomic_DNA.
DR   EMBL; FP236530; CAX37428.1; -; Genomic_DNA.
DR   RefSeq; WP_012855569.1; NC_013511.1.
DR   AlphaFoldDB; Q8GM55; -.
DR   SMR; Q8GM55; -.
DR   STRING; 347256.MHO_2930; -.
DR   PRIDE; Q8GM55; -.
DR   EnsemblBacteria; CAX37428; CAX37428; MHO_2930.
DR   GeneID; 57139970; -.
DR   KEGG; mho:MHO_2930; -.
DR   eggNOG; COG0091; Bacteria.
DR   HOGENOM; CLU_083987_3_1_14; -.
DR   OMA; KRIQPRA; -.
DR   OrthoDB; 1666043at2; -.
DR   Proteomes; UP000002631; Chromosome.
DR   GO; GO:0015934; C:large ribosomal subunit; IEA:InterPro.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR   CDD; cd00336; Ribosomal_L22; 1.
DR   Gene3D; 3.90.470.10; -; 1.
DR   HAMAP; MF_01331_B; Ribosomal_L22_B; 1.
DR   InterPro; IPR001063; Ribosomal_L22.
DR   InterPro; IPR036394; Ribosomal_L22/L17_sf.
DR   InterPro; IPR005727; Ribosomal_L22_bac/chlpt-type.
DR   PANTHER; PTHR13501; PTHR13501; 1.
DR   Pfam; PF00237; Ribosomal_L22; 1.
DR   SUPFAM; SSF54843; SSF54843; 1.
DR   TIGRFAMs; TIGR01044; rplV_bact; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding;
KW   rRNA-binding.
FT   CHAIN           1..129
FT                   /note="50S ribosomal protein L22"
FT                   /id="PRO_0000125178"
FT   CONFLICT        128..129
FT                   /note="DK -> R (in Ref. 1; AAM08940)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   129 AA;  14473 MW;  F3B4C7C41EF32BFB CRC64;
     MAKEILQNSA HASVRMQRIS PRKARLVADL IRYKSATQAI VILKHTHKKA SEIILKLLNS
     AIANATNNAG LDATKLYVTT ILVNDGPTLK RFQPHSRGRA YAILKRTSHF FIELTEINNV
     EEINKKGDK