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RL22_PIG
ID   RL22_PIG                Reviewed;         128 AA.
AC   P67985; P41104;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=60S ribosomal protein L22;
DE   AltName: Full=Heparin-binding protein HBp15;
GN   Name=RPL22;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Submandibular gland;
RX   PubMed=8135813; DOI=10.1006/bbrc.1994.1286;
RA   Fujita Y., Okamoto T., Noshiro M., Kato Y., Takada K., Sato J.D., Ozaki T.,
RA   McKeehan W.L., Crabb J.W., Whitney R.G.;
RT   "A novel heparin-binding protein, HBp15, is identified as mammalian
RT   ribosomal protein L22.";
RL   Biochem. Biophys. Res. Commun. 199:706-713(1994).
CC   -!- FUNCTION: Component of the large ribosomal subunit. The ribosome is a
CC       large ribonucleoprotein complex responsible for the synthesis of
CC       proteins in the cell. {ECO:0000250|UniProtKB:P35268}.
CC   -!- SUBUNIT: Component of the large ribosomal subunit.
CC       {ECO:0000250|UniProtKB:P35268}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P35268}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL22 family.
CC       {ECO:0000305}.
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DR   EMBL; D17654; BAA04547.1; -; mRNA.
DR   PIR; JC2121; JC2121.
DR   RefSeq; NP_999152.1; NM_213987.1.
DR   PDB; 3J7O; EM; 3.40 A; U=1-128.
DR   PDB; 3J7P; EM; 3.50 A; U=1-128.
DR   PDB; 3J7Q; EM; 3.40 A; U=1-128.
DR   PDB; 3J7R; EM; 3.90 A; U=1-128.
DR   PDBsum; 3J7O; -.
DR   PDBsum; 3J7P; -.
DR   PDBsum; 3J7Q; -.
DR   PDBsum; 3J7R; -.
DR   AlphaFoldDB; P67985; -.
DR   SMR; P67985; -.
DR   STRING; 9823.ENSSSCP00000003651; -.
DR   PaxDb; P67985; -.
DR   PeptideAtlas; P67985; -.
DR   PRIDE; P67985; -.
DR   Ensembl; ENSSSCT00000049730; ENSSSCP00000042758; ENSSSCG00000003369.
DR   Ensembl; ENSSSCT00025049467; ENSSSCP00025021170; ENSSSCG00025036285.
DR   Ensembl; ENSSSCT00035005003; ENSSSCP00035001709; ENSSSCG00035004022.
DR   Ensembl; ENSSSCT00050084550; ENSSSCP00050036299; ENSSSCG00050062054.
DR   Ensembl; ENSSSCT00055007866; ENSSSCP00055006220; ENSSSCG00055004004.
DR   Ensembl; ENSSSCT00060060042; ENSSSCP00060025739; ENSSSCG00060044262.
DR   Ensembl; ENSSSCT00070059435; ENSSSCP00070050614; ENSSSCG00070029571.
DR   GeneID; 397047; -.
DR   KEGG; ssc:397047; -.
DR   CTD; 6146; -.
DR   VGNC; VGNC:89022; ICMT.
DR   eggNOG; KOG3434; Eukaryota.
DR   GeneTree; ENSGT00390000017394; -.
DR   HOGENOM; CLU_105624_0_1_1; -.
DR   InParanoid; P67985; -.
DR   OMA; NTAISMY; -.
DR   OrthoDB; 1594080at2759; -.
DR   TreeFam; TF313018; -.
DR   Proteomes; UP000008227; Chromosome 6.
DR   Proteomes; UP000314985; Chromosome 6.
DR   Bgee; ENSSSCG00000003369; Expressed in hindlimb bud and 45 other tissues.
DR   ExpressionAtlas; P67985; baseline and differential.
DR   Genevisible; P67985; SS.
DR   GO; GO:0098556; C:cytoplasmic side of rough endoplasmic reticulum membrane; IDA:UniProtKB.
DR   GO; GO:0022626; C:cytosolic ribosome; IEA:Ensembl.
DR   GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR   GO; GO:0015934; C:large ribosomal subunit; IDA:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0098793; C:presynapse; IEA:Ensembl.
DR   GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:0045182; F:translation regulator activity; IEA:Ensembl.
DR   GO; GO:0046632; P:alpha-beta T cell differentiation; IEA:Ensembl.
DR   GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR   GO; GO:0099577; P:regulation of translation at presynapse, modulating synaptic transmission; IEA:Ensembl.
DR   Gene3D; 3.30.1360.210; -; 1.
DR   InterPro; IPR002671; Ribosomal_L22e.
DR   InterPro; IPR038526; Ribosomal_L22e_sf.
DR   PANTHER; PTHR10064; PTHR10064; 1.
DR   Pfam; PF01776; Ribosomal_L22e; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Heparin-binding; Phosphoprotein;
KW   Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding.
FT   CHAIN           1..128
FT                   /note="60S ribosomal protein L22"
FT                   /id="PRO_0000215503"
FT   MOD_RES         62
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P67984"
FT   MOD_RES         66
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P35268"
FT   MOD_RES         69
FT                   /note="N6-succinyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P67984"
SQ   SEQUENCE   128 AA;  14759 MW;  3F29D8BE70DEF96C CRC64;
     MAPVKKLVAK GGKKKKQVLK FTLDCTHPVE DGIMDAANFE QFLQERIKVN GKAGNLGGGV
     VTIERSKSKI TVTSEVPFSK RYLKYLTKKY LKKNNLRDWL RVVANSKESY ELRYFQINQD
     EEEEEDED
 
 
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