ID   RL22_RAT                Reviewed;         128 AA.
AC   P47198;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=60S ribosomal protein L22;
GN   Name=Rpl22;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Liver;
RX   PubMed=7999786; DOI=10.1016/0167-4781(94)00193-7;
RA   Chan Y.-L., Wool I.G.;
RT   "The primary structure of rat ribosomal protein L22.";
RL   Biochim. Biophys. Acta 1260:113-115(1995).
CC   -!- FUNCTION: Component of the large ribosomal subunit. The ribosome is a
CC       large ribonucleoprotein complex responsible for the synthesis of
CC       proteins in the cell. {ECO:0000250|UniProtKB:P35268}.
CC   -!- SUBUNIT: Component of the large ribosomal subunit.
CC       {ECO:0000250|UniProtKB:P35268}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P35268}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL22 family.
CC       {ECO:0000305}.
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DR   EMBL; X78444; CAA55204.1; -; mRNA.
DR   PIR; S52084; S52084.
DR   RefSeq; NP_112366.1; NM_031104.1.
DR   AlphaFoldDB; P47198; -.
DR   SMR; P47198; -.
DR   BioGRID; 249640; 4.
DR   IntAct; P47198; 9.
DR   MINT; P47198; -.
DR   STRING; 10116.ENSRNOP00000014905; -.
DR   jPOST; P47198; -.
DR   PaxDb; P47198; -.
DR   PRIDE; P47198; -.
DR   GeneID; 81768; -.
DR   KEGG; rno:81768; -.
DR   UCSC; RGD:621189; rat.
DR   CTD; 6146; -.
DR   RGD; 621189; Rpl22.
DR   eggNOG; KOG3434; Eukaryota.
DR   InParanoid; P47198; -.
DR   OrthoDB; 1594080at2759; -.
DR   PhylomeDB; P47198; -.
DR   Reactome; R-RNO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-RNO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   Reactome; R-RNO-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-RNO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   Reactome; R-RNO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-RNO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   PRO; PR:P47198; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IDA:RGD.
DR   GO; GO:0022626; C:cytosolic ribosome; ISO:RGD.
DR   GO; GO:0098978; C:glutamatergic synapse; ISO:RGD.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0098793; C:presynapse; ISO:RGD.
DR   GO; GO:1990904; C:ribonucleoprotein complex; ISO:RGD.
DR   GO; GO:0005840; C:ribosome; IDA:RGD.
DR   GO; GO:0008201; F:heparin binding; ISO:RGD.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003735; F:structural constituent of ribosome; ISO:RGD.
DR   GO; GO:0045182; F:translation regulator activity; ISO:RGD.
DR   GO; GO:0046632; P:alpha-beta T cell differentiation; ISO:RGD.
DR   GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR   GO; GO:0099577; P:regulation of translation at presynapse, modulating synaptic transmission; ISO:RGD.
DR   Gene3D; 3.30.1360.210; -; 1.
DR   InterPro; IPR002671; Ribosomal_L22e.
DR   InterPro; IPR038526; Ribosomal_L22e_sf.
DR   PANTHER; PTHR10064; PTHR10064; 1.
DR   Pfam; PF01776; Ribosomal_L22e; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Heparin-binding; Phosphoprotein; Reference proteome;
KW   Ribonucleoprotein; Ribosomal protein; RNA-binding.
FT   CHAIN           1..128
FT                   /note="60S ribosomal protein L22"
FT                   /id="PRO_0000215504"
FT   MOD_RES         62
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P67984"
FT   MOD_RES         66
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P35268"
FT   MOD_RES         69
FT                   /note="N6-succinyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P67984"
SQ   SEQUENCE   128 AA;  14789 MW;  FC29D8BE6EF8221F CRC64;
     MAPVKKLVAK GGKKKKQVLK FTLDCTHPVE DGIMDAANFE QFLQERIKVN GKAGNLGGGV
     VTIERSKSKI TVTSEEPFSK RYLKYLTKKY LKKNNLRDWL RVVANSKESY ELRYFQINQD
     EEEEEDED