ID   RL22_STRPN              Reviewed;         114 AA.
AC   P61182; Q8GL54; Q9WVU5;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2004, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=50S ribosomal protein L22;
GN   Name=rplV; OrderedLocusNames=SP_0214;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SP#5, and ZR1;
RX   PubMed=10681347; DOI=10.1128/aac.44.3.732-738.2000;
RA   Adrian P.V., Zhao W., Black T.A., Shaw K.J., Hare R.S., Klugman K.P.;
RT   "Mutations in ribosomal protein L16 conferring reduced susceptibility to
RT   evernimicin (SCH27899): implications for mechanism of action.";
RL   Antimicrob. Agents Chemother. 44:732-738(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
RN   [3]
RP   VARIANTS ANTIBIOTIC RESISTANT 3ERY; 4ERY AND 5ROX, AND MUTAGENESIS OF
RP   ALA-93.
RC   STRAIN=CP1000;
RX   PubMed=11751122; DOI=10.1128/aac.46.1.125-131.2002;
RA   Canu A., Malbruny B., Coquemont M., Davies T.A., Appelbaum P.C.,
RA   Leclercq R.;
RT   "Diversity of ribosomal mutations conferring resistance to macrolides,
RT   clindamycin, streptogramin, and telithromycin in Streptococcus
RT   pneumoniae.";
RL   Antimicrob. Agents Chemother. 46:125-131(2002).
RN   [4]
RP   VARIANT CLINICALLY ISOLATED ANTIBIOTIC RESISTANT.
RC   STRAIN=Serotype 3;
RX   PubMed=14519256; DOI=10.3201/eid0909.020810;
RA   Perez-Trallero E., Marimon J.M., Iglesias L., Larruskain J.;
RT   "Fluoroquinolone and macrolide treatment failure in pneumococcal pneumonia
RT   and selection of multidrug-resistant isolates.";
RL   Emerg. Infect. Dis. 9:1159-1162(2003).
RN   [5]
RP   VARIANT TELITHROMYCIN RESISTANT JII8.
RC   STRAIN=02J1095;
RX   PubMed=12917252; DOI=10.1093/jac/dkg348;
RA   Walsh F., Willcock J., Amyes S.;
RT   "High-level telithromycin resistance in laboratory-generated mutants of
RT   Streptococcus pneumoniae.";
RL   J. Antimicrob. Chemother. 52:345-353(2003).
CC   -!- FUNCTION: This protein binds specifically to 23S rRNA; its binding is
CC       stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is
CC       important during the early stages of 50S assembly. It makes multiple
CC       contacts with different domains of the 23S rRNA in the assembled 50S
CC       subunit and ribosome (By similarity). {ECO:0000250}.
CC   -!- FUNCTION: The globular domain of the protein is located near the
CC       polypeptide exit tunnel on the outside of the subunit, while an
CC       extended beta-hairpin is found that lines the wall of the exit tunnel
CC       in the center of the 70S ribosome. {ECO:0000250}.
CC   -!- SUBUNIT: Part of the 50S ribosomal subunit.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL22 family.
CC       {ECO:0000305}.
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DR   EMBL; AF126060; AAD33270.1; -; Genomic_DNA.
DR   EMBL; AF126061; AAD33279.1; -; Genomic_DNA.
DR   EMBL; AE005672; AAK74394.1; -; Genomic_DNA.
DR   EMBL; AY140892; AAN18256.1; -; Genomic_DNA.
DR   PIR; A95025; A95025.
DR   RefSeq; WP_000818137.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; P61182; -.
DR   SMR; P61182; -.
DR   STRING; 170187.SP_0214; -.
DR   DrugBank; DB12825; Lefamulin.
DR   EnsemblBacteria; AAK74394; AAK74394; SP_0214.
DR   GeneID; 60233933; -.
DR   GeneID; 66805421; -.
DR   KEGG; spn:SP_0214; -.
DR   eggNOG; COG0091; Bacteria.
DR   OMA; KRIQPRA; -.
DR   PhylomeDB; P61182; -.
DR   BioCyc; SPNE170187:G1FZB-219-MON; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0015934; C:large ribosomal subunit; IEA:InterPro.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR   CDD; cd00336; Ribosomal_L22; 1.
DR   Gene3D; 3.90.470.10; -; 1.
DR   HAMAP; MF_01331_B; Ribosomal_L22_B; 1.
DR   InterPro; IPR001063; Ribosomal_L22.
DR   InterPro; IPR018260; Ribosomal_L22/L17_CS.
DR   InterPro; IPR036394; Ribosomal_L22/L17_sf.
DR   InterPro; IPR005727; Ribosomal_L22_bac/chlpt-type.
DR   PANTHER; PTHR13501; PTHR13501; 1.
DR   Pfam; PF00237; Ribosomal_L22; 1.
DR   SUPFAM; SSF54843; SSF54843; 1.
DR   TIGRFAMs; TIGR01044; rplV_bact; 1.
DR   PROSITE; PS00464; RIBOSOMAL_L22; 1.
PE   1: Evidence at protein level;
KW   Antibiotic resistance; Ribonucleoprotein; Ribosomal protein; RNA-binding;
KW   rRNA-binding.
FT   CHAIN           1..114
FT                   /note="50S ribosomal protein L22"
FT                   /id="PRO_0000125236"
FT   VARIANT         94
FT                   /note="K -> Q (in mutant JII8; confers telithromycin
FT                   resistance; when associated with a large deletion in the
FT                   upstream region of ErmB)"
FT   VARIANT         95
FT                   /note="G -> D (in strain: 3ERY and 5ROX; confers antibiotic
FT                   resistance)"
FT   VARIANT         99
FT                   /note="P -> Q (in strain: 4ERY; confers antibiotic
FT                   resistance)"
FT   VARIANT         108
FT                   /note="T -> TRTAHIT (in a serotype 3 clinical isolate,
FT                   confers resistance to macrolide and fluoroquinolone
FT                   antibiotics)"
FT   MUTAGEN         93
FT                   /note="A->E: Confers antibiotic resistance."
FT                   /evidence="ECO:0000269|PubMed:11751122"
SQ   SEQUENCE   114 AA;  12200 MW;  8CFF7BF3CB0184D6 CRC64;
     MAEITSAKAM ARTVRVSPRK SRLVLDNIRG KSVADAIAIL TFTPNKAAEI ILKVLNSAVA
     NAENNFGLDK ANLVVSEAFA NEGPTMKRFR PRAKGSASPI NKRTAHITVA VAEK