RL23_RAT
ID RL23_RAT Reviewed; 140 AA.
AC P62832; P23131; P24048; Q29246;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=60S ribosomal protein L23;
GN Name=Rpl23;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Liver;
RX PubMed=1840488; DOI=10.1016/0006-291x(91)91013-3;
RA Chan Y.-L., Paz V., Wool I.G.;
RT "The primary structure of rat ribosomal protein L23.";
RL Biochem. Biophys. Res. Commun. 178:1153-1159(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the large ribosomal subunit. The ribosome is a
CC large ribonucleoprotein complex responsible for the synthesis of
CC proteins in the cell. {ECO:0000250|UniProtKB:P62829}.
CC -!- SUBUNIT: Component of the large ribosomal subunit.
CC {ECO:0000250|UniProtKB:P62829}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62829}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL14 family.
CC {ECO:0000305}.
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DR EMBL; X58200; CAA41177.1; -; mRNA.
DR EMBL; BC058500; AAH58500.1; -; mRNA.
DR PIR; JH0418; R5RT23.
DR RefSeq; NP_001007600.1; NM_001007599.2.
DR AlphaFoldDB; P62832; -.
DR SMR; P62832; -.
DR BioGRID; 247952; 6.
DR IntAct; P62832; 6.
DR MINT; P62832; -.
DR STRING; 10116.ENSRNOP00000005471; -.
DR iPTMnet; P62832; -.
DR PhosphoSitePlus; P62832; -.
DR jPOST; P62832; -.
DR PaxDb; P62832; -.
DR PRIDE; P62832; -.
DR GeneID; 29282; -.
DR KEGG; rno:29282; -.
DR UCSC; RGD:62067; rat.
DR CTD; 9349; -.
DR RGD; 62067; Rpl23.
DR VEuPathDB; HostDB:ENSRNOG00000004107; -.
DR eggNOG; KOG0901; Eukaryota.
DR HOGENOM; CLU_095071_3_0_1; -.
DR InParanoid; P62832; -.
DR OMA; AKEVLCI; -.
DR OrthoDB; 1374830at2759; -.
DR PhylomeDB; P62832; -.
DR TreeFam; TF300913; -.
DR Reactome; R-RNO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-RNO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-RNO-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-RNO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-RNO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-RNO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:P62832; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000004107; Expressed in thymus and 20 other tissues.
DR Genevisible; P62832; RN.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IDA:RGD.
DR GO; GO:0022626; C:cytosolic ribosome; ISO:RGD.
DR GO; GO:0005730; C:nucleolus; ISO:RGD.
DR GO; GO:0005654; C:nucleoplasm; ISO:RGD.
DR GO; GO:0014069; C:postsynaptic density; IDA:SynGO.
DR GO; GO:0032991; C:protein-containing complex; ISO:RGD.
DR GO; GO:0005840; C:ribosome; IDA:RGD.
DR GO; GO:0070180; F:large ribosomal subunit rRNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:RGD.
DR GO; GO:0001223; F:transcription coactivator binding; ISO:RGD.
DR GO; GO:1990948; F:ubiquitin ligase inhibitor activity; ISO:RGD.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; ISO:RGD.
DR GO; GO:0072717; P:cellular response to actinomycin D; ISO:RGD.
DR GO; GO:0070314; P:G1 to G0 transition; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:1904667; P:negative regulation of ubiquitin protein ligase activity; ISO:RGD.
DR GO; GO:2000059; P:negative regulation of ubiquitin-dependent protein catabolic process; ISO:RGD.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:RGD.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
DR GO; GO:1901798; P:positive regulation of signal transduction by p53 class mediator; ISO:RGD.
DR GO; GO:0050821; P:protein stabilization; ISO:RGD.
DR GO; GO:0032986; P:protein-DNA complex disassembly; ISO:RGD.
DR GO; GO:1903450; P:regulation of G1 to G0 transition; ISO:RGD.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR Gene3D; 2.40.150.20; -; 1.
DR HAMAP; MF_01367; Ribosomal_L14; 1.
DR InterPro; IPR036853; Ribosomal_L14_sf.
DR InterPro; IPR000218; Ribosomal_L14P.
DR InterPro; IPR019972; Ribosomal_L14P_CS.
DR PANTHER; PTHR11761; PTHR11761; 1.
DR Pfam; PF00238; Ribosomal_L14; 1.
DR SMART; SM01374; Ribosomal_L14; 1.
DR SUPFAM; SSF50193; SSF50193; 1.
DR PROSITE; PS00049; RIBOSOMAL_L14; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Phosphoprotein; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein.
FT CHAIN 1..140
FT /note="60S ribosomal protein L23"
FT /id="PRO_0000128616"
FT MOD_RES 17
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P62829"
FT MOD_RES 38
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:P62829"
SQ SEQUENCE 140 AA; 14865 MW; 807E14139B2EB0B5 CRC64;
MSKRGRGGSS GAKFRISLGL PVGAVINCAD NTGAKNLYII SVKGIKGRLN RLPAAGVGDM
VMATVKKGKP ELRKKVHPAV VIRQRKSYRR KDGVFLYFED NAGVIVNNKG EMKGSAITGP
VAKECADLWP RIASNAGSIA
