ID   RL24_DANRE              Reviewed;         157 AA.
AC   Q8JGR4; Q6PBZ4;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=60S ribosomal protein L24;
GN   Name=rpl24;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RC   TISSUE=Embryo;
RX   PubMed=12006978; DOI=10.1038/ng896;
RA   Golling G., Amsterdam A., Sun Z., Antonelli M., Maldonado E., Chen W.,
RA   Burgess S., Haldi M., Artzt K., Farrington S., Lin S.-Y., Nissen R.M.,
RA   Hopkins N.;
RT   "Insertional mutagenesis in zebrafish rapidly identifies genes essential
RT   for early vertebrate development.";
RL   Nat. Genet. 31:135-140(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the large ribosomal subunit. The ribosome is a
CC       large ribonucleoprotein complex responsible for the synthesis of
CC       proteins in the cell (By similarity). Plays an essential role in early
CC       embryonic development (PubMed:12006978). {ECO:0000250|UniProtKB:P83731,
CC       ECO:0000269|PubMed:12006978}.
CC   -!- SUBUNIT: Component of the large ribosomal subunit.
CC       {ECO:0000250|UniProtKB:P83731}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P83731}.
CC   -!- DISRUPTION PHENOTYPE: Embryos show various defects including smaller
CC       head and eyes. {ECO:0000269|PubMed:12006978}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL24 family.
CC       {ECO:0000305}.
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DR   EMBL; AY099532; AAM28220.1; -; mRNA.
DR   EMBL; BC059530; AAH59530.1; -; mRNA.
DR   RefSeq; NP_775342.2; NM_173235.3.
DR   AlphaFoldDB; Q8JGR4; -.
DR   SMR; Q8JGR4; -.
DR   STRING; 7955.ENSDARP00000126732; -.
DR   PaxDb; Q8JGR4; -.
DR   PRIDE; Q8JGR4; -.
DR   GeneID; 192301; -.
DR   KEGG; dre:192301; -.
DR   CTD; 6152; -.
DR   ZFIN; ZDB-GENE-020419-25; rpl24.
DR   eggNOG; KOG1722; Eukaryota.
DR   InParanoid; Q8JGR4; -.
DR   OrthoDB; 1502432at2759; -.
DR   PhylomeDB; Q8JGR4; -.
DR   Reactome; R-DRE-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-DRE-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-DRE-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   Reactome; R-DRE-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-DRE-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   Reactome; R-DRE-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-DRE-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   PRO; PR:Q8JGR4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:0043009; P:chordate embryonic development; IMP:ZFIN.
DR   GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR   CDD; cd00472; Ribosomal_L24e_L24; 1.
DR   Gene3D; 2.30.170.20; -; 1.
DR   InterPro; IPR038630; L24e/L24_sf.
DR   InterPro; IPR000988; Ribosomal_L24e-rel.
DR   InterPro; IPR023442; Ribosomal_L24e_CS.
DR   InterPro; IPR011017; TRASH_dom.
DR   PANTHER; PTHR10792; PTHR10792; 1.
DR   Pfam; PF01246; Ribosomal_L24e; 1.
DR   SMART; SM00746; TRASH; 1.
DR   PROSITE; PS01073; RIBOSOMAL_L24E; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Reference proteome; Ribonucleoprotein;
KW   Ribosomal protein.
FT   CHAIN           1..157
FT                   /note="60S ribosomal protein L24"
FT                   /id="PRO_0000136871"
FT   REGION          95..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..121
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        122..136
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        24
FT                   /note="V -> I (in Ref. 2; AAH59530)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   157 AA;  17869 MW;  9C36D392CA2E0B1F CRC64;
     MKVELCSFSG YKIYPGHGRR YARVDGKVFQ FLNAKCESAF LSKRNPRQIN WTVLYRRKHK
     KGQSEEVSKK RTRRAVKFQR AITGASLAEI LAKRNQKPEV RKAQREQAIR AAKEAKKAKQ
     ATKKQTTQSS KAPAKSAQKQ KIAKPMKVSA PRVGGKR