ID   1433T_CHICK             Reviewed;         245 AA.
AC   Q5ZMD1;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=14-3-3 protein theta;
GN   Name=YWHAQ; ORFNames=RCJMB04_2i3;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Adapter protein implicated in the regulation of a large
CC       spectrum of both general and specialized signaling pathways. Binds to a
CC       large number of partners, usually by recognition of a phosphoserine or
CC       phosphothreonine motif. Binding generally results in the modulation of
CC       the activity of the binding partner (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer, and heterodimer with other family members.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the 14-3-3 family. {ECO:0000305}.
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DR   EMBL; AJ719453; CAG31112.1; -; mRNA.
DR   RefSeq; NP_001006415.1; NM_001006415.1.
DR   RefSeq; XP_015131523.1; XM_015276037.1.
DR   PDB; 2YEZ; X-ray; 2.90 A; C=110-119.
DR   PDBsum; 2YEZ; -.
DR   AlphaFoldDB; Q5ZMD1; -.
DR   SMR; Q5ZMD1; -.
DR   BioGRID; 682688; 2.
DR   IntAct; Q5ZMD1; 1.
DR   STRING; 9031.ENSGALP00000036122; -.
DR   PaxDb; Q5ZMD1; -.
DR   Ensembl; ENSGALT00000036909; ENSGALP00000036122; ENSGALG00000016433.
DR   Ensembl; ENSGALT00000082606; ENSGALP00000052649; ENSGALG00000016433.
DR   GeneID; 421932; -.
DR   KEGG; gga:421932; -.
DR   CTD; 10971; -.
DR   VEuPathDB; HostDB:geneid_421932; -.
DR   eggNOG; KOG0841; Eukaryota.
DR   GeneTree; ENSGT01050000244817; -.
DR   HOGENOM; CLU_058290_1_0_1; -.
DR   InParanoid; Q5ZMD1; -.
DR   OMA; FEMATTI; -.
DR   OrthoDB; 1176818at2759; -.
DR   PhylomeDB; Q5ZMD1; -.
DR   TreeFam; TF102002; -.
DR   Reactome; R-GGA-5628897; TP53 Regulates Metabolic Genes.
DR   Reactome; R-GGA-9614399; Regulation of localization of FOXO transcription factors.
DR   PRO; PR:Q5ZMD1; -.
DR   Proteomes; UP000000539; Chromosome 3.
DR   Bgee; ENSGALG00000016433; Expressed in cerebellum and 12 other tissues.
DR   ExpressionAtlas; Q5ZMD1; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   CDD; cd10023; 14-3-3_theta; 1.
DR   Gene3D; 1.20.190.20; -; 1.
DR   InterPro; IPR000308; 14-3-3.
DR   InterPro; IPR023409; 14-3-3_CS.
DR   InterPro; IPR036815; 14-3-3_dom_sf.
DR   InterPro; IPR023410; 14-3-3_domain.
DR   InterPro; IPR042584; 14-3-3_theta.
DR   PANTHER; PTHR18860; PTHR18860; 1.
DR   Pfam; PF00244; 14-3-3; 1.
DR   PIRSF; PIRSF000868; 14-3-3; 1.
DR   PRINTS; PR00305; 1433ZETA.
DR   SMART; SM00101; 14_3_3; 1.
DR   SUPFAM; SSF48445; SSF48445; 1.
DR   PROSITE; PS00796; 1433_1; 1.
DR   PROSITE; PS00797; 1433_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Reference proteome.
FT   CHAIN           1..245
FT                   /note="14-3-3 protein theta"
FT                   /id="PRO_0000058641"
FT   SITE            56
FT                   /note="Interaction with phosphoserine on interacting
FT                   protein"
FT                   /evidence="ECO:0000250"
FT   SITE            127
FT                   /note="Interaction with phosphoserine on interacting
FT                   protein"
FT                   /evidence="ECO:0000250"
FT   HELIX           114..117
FT                   /evidence="ECO:0007829|PDB:2YEZ"
SQ   SEQUENCE   245 AA;  27782 MW;  35DF8AC951A252A8 CRC64;
     MDKTELIQKA KLAEQAERYD DMATCMKAVT EQGAELSNEE RNLLSVAYKN VVGGRRSAWR
     VISSIEQKTD TSDKKMQLIK DYREKVESEL RSICTTVLEL LDKYLIANAT NPESKVFYLK
     MKGDYFRYLA EVACGDDRKQ TIENSQGAYQ EAFDISKKEM QPTHPIRLGL ALNFSVFYYE
     ILNNPELACT LAKTAFDEAI AELDTLNEDS YKDSTLIMQL LRDNLTLWTS DSAGEECDAA
     EGAEN