RL25_STAA3
ID RL25_STAA3 Reviewed; 217 AA.
AC Q2FJE0;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=50S ribosomal protein L25 {ECO:0000255|HAMAP-Rule:MF_01334};
DE AltName: Full=General stress protein CTC {ECO:0000255|HAMAP-Rule:MF_01334};
GN Name=rplY {ECO:0000255|HAMAP-Rule:MF_01334};
GN Synonyms=ctc {ECO:0000255|HAMAP-Rule:MF_01334};
GN OrderedLocusNames=SAUSA300_0479;
OS Staphylococcus aureus (strain USA300).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=367830;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=USA300;
RX PubMed=16517273; DOI=10.1016/s0140-6736(06)68231-7;
RA Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA Perdreau-Remington F.;
RT "Complete genome sequence of USA300, an epidemic clone of community-
RT acquired meticillin-resistant Staphylococcus aureus.";
RL Lancet 367:731-739(2006).
CC -!- FUNCTION: This is one of the proteins that binds to the 5S RNA in the
CC ribosome where it forms part of the central protuberance.
CC {ECO:0000255|HAMAP-Rule:MF_01334}.
CC -!- SUBUNIT: Part of the 50S ribosomal subunit; part of the 5S
CC rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA
CC independently of L5 and L18. {ECO:0000255|HAMAP-Rule:MF_01334}.
CC -!- SIMILARITY: Belongs to the bacterial ribosomal protein bL25 family. CTC
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_01334}.
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DR EMBL; CP000255; ABD22748.1; -; Genomic_DNA.
DR RefSeq; WP_000157650.1; NZ_CP027476.1.
DR PDB; 4WCE; X-ray; 3.53 A; S=1-217.
DR PDB; 4WF9; X-ray; 3.43 A; S=1-217.
DR PDB; 4WFA; X-ray; 3.39 A; S=1-217.
DR PDB; 4WFB; X-ray; 3.43 A; S=1-217.
DR PDB; 5HKV; X-ray; 3.66 A; S=1-217.
DR PDB; 6DDG; EM; 3.10 A; H=1-217.
DR PDB; 6HMA; EM; 2.65 A; T=2-95.
DR PDBsum; 4WCE; -.
DR PDBsum; 4WF9; -.
DR PDBsum; 4WFA; -.
DR PDBsum; 4WFB; -.
DR PDBsum; 5HKV; -.
DR PDBsum; 6DDG; -.
DR PDBsum; 6HMA; -.
DR AlphaFoldDB; Q2FJE0; -.
DR SMR; Q2FJE0; -.
DR EnsemblBacteria; ABD22748; ABD22748; SAUSA300_0479.
DR GeneID; 66838782; -.
DR KEGG; saa:SAUSA300_0479; -.
DR HOGENOM; CLU_075939_2_1_9; -.
DR OMA; HVDFYEV; -.
DR Proteomes; UP000001939; Chromosome.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR GO; GO:0008097; F:5S rRNA binding; IEA:InterPro.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR CDD; cd00495; Ribosomal_L25_TL5_CTC; 1.
DR Gene3D; 2.170.120.20; -; 1.
DR Gene3D; 2.40.240.10; -; 1.
DR HAMAP; MF_01334; Ribosomal_L25_CTC; 1.
DR InterPro; IPR020056; Rbsml_L25/Gln-tRNA_synth_N.
DR InterPro; IPR029751; Ribosomal_L25.
DR InterPro; IPR011035; Ribosomal_L25/Gln-tRNA_synth.
DR InterPro; IPR020057; Ribosomal_L25_b-dom.
DR InterPro; IPR037121; Ribosomal_L25_C.
DR InterPro; IPR001021; Ribosomal_L25_long.
DR Pfam; PF01386; Ribosomal_L25p; 1.
DR Pfam; PF14693; Ribosomal_TL5_C; 1.
DR SUPFAM; SSF50715; SSF50715; 1.
DR TIGRFAMs; TIGR00731; bL25_bact_ctc; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Ribonucleoprotein; Ribosomal protein; RNA-binding;
KW rRNA-binding.
FT CHAIN 1..217
FT /note="50S ribosomal protein L25"
FT /id="PRO_0000244244"
FT REGION 178..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..217
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT STRAND 4..6
FT /evidence="ECO:0007829|PDB:4WF9"
FT HELIX 16..22
FT /evidence="ECO:0007829|PDB:6HMA"
FT TURN 23..25
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 26..33
FT /evidence="ECO:0007829|PDB:6HMA"
FT TURN 34..36
FT /evidence="ECO:0007829|PDB:6DDG"
FT STRAND 39..44
FT /evidence="ECO:0007829|PDB:6HMA"
FT HELIX 45..55
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 61..65
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 68..80
FT /evidence="ECO:0007829|PDB:6HMA"
FT TURN 81..84
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 85..93
FT /evidence="ECO:0007829|PDB:6HMA"
FT STRAND 99..103
FT /evidence="ECO:0007829|PDB:4WFA"
FT STRAND 114..116
FT /evidence="ECO:0007829|PDB:4WF9"
FT STRAND 121..131
FT /evidence="ECO:0007829|PDB:4WFA"
FT STRAND 134..136
FT /evidence="ECO:0007829|PDB:4WF9"
FT STRAND 144..146
FT /evidence="ECO:0007829|PDB:4WFA"
FT STRAND 156..158
FT /evidence="ECO:0007829|PDB:4WFA"
SQ SEQUENCE 217 AA; 23788 MW; 1F6A316EA0A45108 CRC64;
MASLKSIIRQ GKQTRSDLKQ LRKSGKVPAV VYGYGTKNVS VKVDEVEFIK VIREVGRNGV
IELGVGSKTI KVMVADYQFD PLKNQITHID FLAINMSEER TVEVPVQLVG EAVGAKEGGV
VEQPLFNLEV TATPDNIPEA IEVDITELNI NDSLTVADVK VTGDFKIEND SAESVVTVVA
PTEEPTEEEI EAMEGEQQTE EPEVVGESKE DEEKTEE
